A short insertion mutation disrupts genesis of miR-16 and causes increased body weight in domesticated chicken

Jia, Xiaoyun; Lin, Huiran; Nie, Qinghua; Zhang, Xiquan; Lamont, Susan J.

doi:10.1038/srep36433

Cited by 36 publications

(31 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RB1 gene is reported to be an association with body weight and bone traits (Liu et al 2008), and early growth and development (Chen et al 2012;Xu et al 2013) in chicken. CAKP2 gene is believed to play a role in growth traits (Zhang et al 2010), its expression is decreased in high weight chicken lines (Jia et al 2016).…”

Section: Resultsmentioning

confidence: 99%

Genome-wide association study for carcase traits in spent hens at 72 weeks old

Shen

et al. 2018

Italian Journal of Animal Science

View full text Add to dashboard Cite

To determine the genetic architecture underlying spent hen carcase traits, especially in late laying, we used 1512 hens generated from Dongxiang Blue-Shelled and White Leghorn chickens to implement genome-wide association studies by high-density arrays. A total of 266 loci that mapped to (Gallus gallus chromosome) GGA1, GGA4 and GGA27 were detected. After linkage disequilibrium analysis, five SNPs were considered as candidate markers because they located on or near the genes CKAP2, RB1, CCKAR, NCAPG and IGF2BP1. The heritability of all carcase traits was high, and SNP effects ranged from 3.24% to 8.72%. These findings provide new insights into the genetic architecture of carcase traits in spent layer hens. HIGHLIGHTS Resource population generated from two breeds were used to measure carcass traits in spent hens. A total of 266 loci association with carcass traits located on GGA1, GGA4, and GGA27. Five putative candidate genes CKAP2, RB1, CCKAR, NCAPG and IGFBP1 were obtained after gene annotation.

show abstract

Section: Resultsmentioning

confidence: 99%

Genome-wide association study for carcase traits in spent hens at 72 weeks old

Shen

et al. 2018

Italian Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…The allelic frequency of genes can re ect the genetic diversity between different groups, indicating that new mutations are introduced to some extent [2,23]. In recent decades, the breeding of commercial broilers and layers has focused on growth and reproductive traits, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, chicken breeds play an indispensable role in husbandry. The body weight of animals as an economic trait can directly re ect the balance of nutrients through digestive absorption and energy metabolism, leading to skeletal growth and lean or fat deposition [2,3]. G-protein subunit beta 1 like (GNB1L) encodes a G-protein beta-subunit-like polypeptide that lacks homology with known proteins [4].…”

Section: Introductionmentioning

confidence: 99%

A 31-bp indel in the 5' UTR region of GNB1L is significantly associated with chicken body weight and carcass traits

Ren

Yang

Lin

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: G-protein subunit beta 1 like ( GNB1L ) encodes a G-protein beta-subunit-like polypeptide. Chicken GNB1L is upregulated in the breast muscle of high feed efficiency chickens, and its expression is 1.52-fold that in low feed efficiency chickens. However, no report has described the effects of GNB1L indels on the chicken carcass and growth traits. Results: This study identified a 31-bp indel in the 5' untranslated region (UTR) of GNB1L and elucidated the effect of this gene mutation on the carcass and growth traits in chickens. The 31-bp indel showed a highly significant association with the body weight at 8 different stages and was significantly correlated with daily gains at 0 to 4 weeks and 4 to 8 weeks. Similarly, the mutation was significantly associated with small intestine length, breast width, breast depth and breast muscle weight. Moreover, DD and ID were superior genotypes for chicken growth and carcass traits. Conclusions: These results show that the 31-bp indel of GNB1L significantly affects chicken body weight and carcass traits and can serve as a candidate molecular marker for chicken genetics and breeding programs.

show abstract

“…population [27,[29][30][31][32][33][34][35][36][37][38]. The SNPs of candidate genes in the F2 population [39][40][41][42][43][44][45] are summarized in Table 1.…”

Section: Application Of Genetics and Genomics In Poultry Sciencementioning

confidence: 99%

Detection and Utility of Genetic Variation in Chinese Local Chicken Breeds

Han¹,

Li²,

Guo³

et al. 2018

Application of Genetics and Genomics in Poultry Science

View full text Add to dashboard Cite

China has a wide variety of indigenous chicken breeds. Most of these local chicken varieties have valuable genetic features. These resources could provide valuable breeding material for the poultry industry in China and even for the rest of the world. Assessment of genetic differences of these important chicken genetic resources is an important prerequisite to establish efficient conservation and utilization. Up to now, several types of genetic variations have been identified across genomes, and the area of genetic variation in the chicken genome seems to be a rapidly growing research topic in China. These research data can also provide additional evidence for our understanding of chicken genome variation, developing molecular markers, and elucidating the association between genetic variations and phenotypes in the future. This chapter reviews the research progress of molecular genetic variation in Chinese native chicken breeds in recent years.

show abstract

A short insertion mutation disrupts genesis of miR-16 and causes increased body weight in domesticated chicken

Cited by 36 publications

References 36 publications

Genome-wide association study for carcase traits in spent hens at 72 weeks old

Genome-wide association study for carcase traits in spent hens at 72 weeks old

A 31-bp indel in the 5' UTR region of GNB1L is significantly associated with chicken body weight and carcass traits

Detection and Utility of Genetic Variation in Chinese Local Chicken Breeds

Contact Info

Product

Resources

About