A short and efficient synthesis of (-) Mintlactone and (+) iso-mintlactone

An Efficient Procedure for Preparation ofC‐ andN‐Protected 1‐Aminocyclobutane Carboxylic Acid

“…To our knowledge, this is the first reported conversion of a quaternary a-bromo ester into the corresponding amino acid via the azide. Since tertiary a-bromo esters can be accessed by bromination of the corresponding esters by known methods, [16,17] the methodology reported in this paper should be applicable to the synthesis of a wide range of quaternary a-amino acids. In conclusion, we have described a highly efficient procedure for the synthesis of both protected forms of 1-aminocyclobutane carboxylic acid.…”

Syntheses of Mintlactone and Isomintlactone

“…Isopulegol and its diastereomers are commercially available, but they can be also obtained by thermal cyclization of citronellal. 14,15 Chavan et al, 16 synthesized (-)-mintlactone (1) from (-)-isopulegol (17). The sequence described by the authors consists of an anti-Markovnikov addition of water to 17, followed by oxidation of the primary alcohol 18 and in situ lactonization.…”

Synthesis and Crystal Structure of Pyrazoline Derivative of Pulegone

“…[7][8][9][10][11] (R)-(+)-Pulegone (1) had been used for the synthesis of pheromones. 1-6 This monoterpene and its isomers had been utilized as chiral building blocks for the total synthesis of natural compounds.…”