A shared cognitive and neural basis underpinning cognitive apathy and planning in behavioural-variant frontotemporal dementia and Alzheimer's disease

Eggins, Peta; Wong, Stephanie; Wei, Grace; Hodges, John R.; Piguet, Olivier; Irish, Muireann; Kumfor, Fiona

doi:10.1016/j.cortex.2022.05.012

Cited by 11 publications

(8 citation statements)

References 89 publications

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“…Eight studies used NPI [ 21 , 76 , 78 , 80 , 82 , 84 – 86 ], and five studies used AES [ 14 , 23 , 78 , 81 ]. One study used LARS [ 12 ], three used CBI-R [ 21 , 76 , 77 ], two used the Motivation and Energy Inventory (MEI) [ 76 , 78 ], three used the Snaith-Hamilton Pleasure Scale (SHAPS) [ 76 , 78 , 79 ], one used DAD [ 21 ], two used the Social and Emotional Assessment (Mini-SEA) [ 82 , 87 ], one used AS [ 87 ], DAS was used in four studies [ 23 , 79 , 83 , 88 ], one used the goal-directed behaviors (GDB) [ 81 ], and one used FBI [ 89 ]. Interestingly, one of the studies investigating bvFTD phenotypes related to WM changes found discordant scores on several apathy administration tests [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

“…Concerning cognitive apathy, an MRI study demonstrated that the presence of a deficit in planning ability is a predictor for a worsening in cognitive decline in both bvFTD and AD and it shares similar pathways with apathy. More precisely, alterations in the lateral and medial prefrontal and lateral temporal cortices as well as subcortical regions including the hippocampus, striatum, and thalamus were detected in both patients with apathy affected by AD and bvFTD [ 88 ]. Finally, O’Connor et al evaluated the importance of considering anhedonia as a primary presenting feature of bvFTD and semantic dementia, with neural drivers distinct from those of apathy or depression.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review

Parrotta,

Cacciatore,

D’Andrea

et al. 2023

Neurol Sci

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Objectives The aim of this review is to provide an overview on prevalence and clinical tools for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings obtained from studies in patients with apathy in different forms of dementia, including Alzheimer’s disease (AD), vascular (VaD) and mixed dementia, frontotemporal dementia (FTD), and Parkinson’s disease dementia (PDD). Methods Randomized controlled trials, non-randomized controlled trials, controlled before–after studies, and interrupted time series from four databases (WebOfScience, Scopus, Pubmed, and PsycINFO) addressing apathy in adults or older people aged over 65 years of age affected by dementia were included. Results The prevalence of apathy was 26–82% for AD, 28.6–91.7 for VaD, 29–97.5% in PDD, and 54.8–88.0 in FTD. The assessment of apathy was not consistent in the reviewed studies. Methylphenidate was the most successful pharmacological treatment for apathy. Neurobiological studies highlighted the relationship between both structural and functional brain areas and the presence or severity of apathy. Conclusion Apathy is a very common disorder in all types of dementia, although it is often underdiagnosed and undertreated. Further studies are needed to investigate its diagnosis and management. A consensus on the different evaluation scales should be achieved.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review

Parrotta,

Cacciatore,

D’Andrea

et al. 2023

Neurol Sci

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“…This finding is in line with increasing evidence for the co-occurrence of apathy and disinhibition in individuals with NDD (Lansdall et al, 2017; Passamonti et al, 2018; Sheelakumari et al, 2020), whereas previously, these symptoms were considered to be opposite ends of a spectrum of motivated decision-making (Sinha et al, 2013). Moreover, recent work has demonstrated the co-occurrence of cognitive apathy on the DAS and planning ability, suggesting that the contribution of apathy to executive functions likely depends on the type/dimension of apathy symptoms (Eggins et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The Role of Apathy in Spontaneous Verbal and Nonverbal Behaviors: A Transdiagnostic Pilot Study in Neurodegeneration

Horne

Ceslis

Mosley

et al. 2023

Cognitive and Behavioral Neurology

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Background: Apathy, characterized by a quantifiable reduction in motivation or goal-directed behavior, is a multidimensional syndrome that has been observed across many neurodegenerative diseases. Objective: To develop a novel task measuring spontaneous action initiation (ie, a nonverbal equivalent to spontaneous speech tasks) and to investigate the association between apathy and executive functions such as the voluntary initiation of speech and actions and energization (ie, ability to initiate and sustain a response). Method: We compared the energization and executive functioning performance of 10 individuals with neurodegenerative disease and clinically significant apathy with that of age-matched healthy controls (HC). We also investigated the association between self-reported scores on the Apathy Evaluation Scale (AES) and performance on energization tasks. Results: The individuals with apathy made significantly fewer task-related actions than the HC on the novel spontaneous action task, and their scores on the AES were negatively correlated with spontaneous task-related actions, providing preliminary evidence for the task’s construct validity. In addition, the individuals with apathy performed more poorly than the HC on all of the energization tasks, regardless of task type or stimulus modality, suggesting difficulty in sustaining voluntary responding over time. Most of the tasks also correlated negatively with the AES score. However, the individuals with apathy also performed more poorly on some of the executive function tasks, particularly those involving self-monitoring. Conclusion: Our work presents a novel experimental task for measuring spontaneous action initiation—a key symptom of apathy—and suggests a possible contribution of apathy to neuropsychological deficits such as poor energization.

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“…Apathy is defined as a reduction in motivation and frequency of goal-directed cognitive, emotional, and/or social activities with respect to a previous level of functioning [1]. As a neuropsychiatric syndrome, apathy occurs in several neurological diseases; positive associations between levels of apathy and cognitive dysfunctions have been observed in mild cognitive impairment [2,3], dementia [4], Parkinson's disease [5][6][7], multiple sclerosis [8,9], amyotrophic lateral sclerosis [10], Huntington's disease [11], and stroke [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of apathy in non-clinical populations: validation, psychometric properties, and normative data of the Italian version of Apathy-Motivation Index (AMI)

et al. 2023

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Introduction Evaluation of apathy in non-clinical populations is relevant to identify individuals at risk for developing cognitive decline in later stages of life, and it should be performed with questionnaires specifically designed for healthy individuals, such as the Apathy-Motivation Index (AMI); therefore, the aim of the present study was to validate the AMI in a healthy Italian population, and to provide normative data of the scale. Materials and methods Data collection was performed using a survey completed by 500 healthy participants; DAS, MMQ-A, BIS-15, PHQ-9, and GAD-7 were used to investigate convergent and divergent validity. Internal consistency and factorial structure were also evaluated. A regression-based procedure and receiver operating characteristics (ROC) analyses were used to evaluate the influence of socio-demographic variables on AMI scores and to provide adjusting factors and three cut-offs for the detection of mild, moderate, and severe apathy. Results The Italian version of the AMI included 17 items (one item was removed because it was not internally consistent) and demonstrated good psychometric properties. The three-factor structure of AMI was confirmed. Multiple regression analysis revealed no effect of sociodemographic variables on the total AMI score. ROC analyses revealed three cut-offs of 1.5, 1.66, and 2.06 through the Youden’s J statistic to detect mild, moderate, and severe apathy, respectively. Conclusion The Italian version of the AMI reported similar psychometric properties, factorial structure, and cut-offs to the original scale. This may help researchers and clinicians to identify people at risk and address them in specific interventions to lower their apathy levels.

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A shared cognitive and neural basis underpinning cognitive apathy and planning in behavioural-variant frontotemporal dementia and Alzheimer's disease

Cited by 11 publications

References 89 publications

Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review

Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review

The Role of Apathy in Spontaneous Verbal and Nonverbal Behaviors: A Transdiagnostic Pilot Study in Neurodegeneration

Evaluation of apathy in non-clinical populations: validation, psychometric properties, and normative data of the Italian version of Apathy-Motivation Index (AMI)

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