The proposed method, called probabilistic nodes combination (PNC), is the method of 2D curve interpolation and modeling using the set of key points (knots or nodes). Nodes can be treated as characteristic points of the object for modeling. The model of each individual symbol or data can be built by choice of probability distribution function and nodes combination. PNC modeling via nodes combination and parameter γ as probability distribution function enables curve parameterization and interpolation for each specific data or handwritten symbol. Two-dimensional curve is modeled and interpolated via nodes combination and different functions as discrete or continuous probability distribution functions: polynomial, sine, cosine, tangent, cotangent, logarithm, exponent, arcsin, arccos, arctan, arccot or power function. The novelty of the paper consists of two generalizations: generalization of previous MHR method with various nodes combinations and generalization of linear interpolation with different (no basic) probability distribution functions and nodes combinations.