A Sham Controlled Trial of Transurethral Microwave Therapy with Subsequent Treatment of the Control Group

Bdesha, Amarjit; Bunce, C J; Snell, Michael; Witherow, R. O’n.

doi:10.1016/s0022-5347(17)32761-1

Cited by 38 publications

(12 citation statements)

References 14 publications

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“…The study comprised a review of patients who underwent TUMT between October 1990 and June 1992; this group included 40 patients who were randomized to a comparison of sham and TUMT treatment [ 5]. The sham group subsequently underwent TUMT as it was not considered ethically feasible to leave them untreated; thus the present review includes 67 patients.…”

Section: Methodsmentioning

confidence: 99%

“…Maximum flow rates (Q max ) were recorded on two occasions, with a voided volume of >150 mL, and abdominal ultrasonography was performed to measure the post‐void residual urine volume (PVR). Symptoms were assessed using the Boyarsky score (Table 1) in 27 patients who underwent treatment between October 1990 and June 1991 and the 40 patients initially recruited for the study of sham and TUMT [ 5] were assessed using the modified WHO questionnaire (Table 2), from which the AUA symptom score was derived.…”

Section: Methodsmentioning

confidence: 99%

“…Numerous sham‐controlled studies of TUMT have now been performed [ 4–10]; these have supported the use of TUMT in treating BPH, with one exception [ 10]; indeed De Wildt et al stated that ‘a beneficial effect of heating at thermotherapy temperatures is conclusive and that further sham studies would be unethical’ [ 8]. The follow‐up in these and other studies [ 11–14] has been for up to 1 year, but there are few studies reporting the longer term effects of TUMT [ 15–18], and none of these have followed patients for more than 3 years.…”

Section: Introductionmentioning

confidence: 99%

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Microwave thermotherapy: a long‐term follow‐up of 67 patients from a single centre

Glass

Bdesha

Witherow

1998

British Journal of Urology

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Objective To determine the long‐term therapeutic value of transurethral microwave thermotherapy (TUMT) in the treatment of bladder outflow obstruction secondary to benign prostatic hyperplasia (BPH). Patients and methods A total of 67 patients with BPH, assessed using symptom scores and measurements of urinary flow rate, underwent TUMT using the Leo Microthermer system (Laser Electro Optics Ltd, London, UK) between October 1990 and June 1992. Follow‐up information was obtained on 60 patients (90%). If they had undergone no further treatment for their BPH, they were re‐assessed with symptom scores and measurements of flow rate. Results The mean follow‐up was 52.4 months; eight of the 67 patients had died and seven were lost to follow‐up. Sixteen of the remaining 52 (31%) had undergone another treatment for BPH; one patient developed prostatitis and one developed localized carcinoma of the prostate. Thirty‐four patients had had no further treatment, 29 of whom attended for assessment. In these patients, a statistically significant improvement in both the symptom score and flow rate was maintained at 4 years. No patients developed retrograde ejaculation. Conclusion This is the first study to report a follow‐up of at least 4 years after TUMT with any device. Treatment with the Leo Microthermer provided at least a 50% symptomatic improvement in 16 of 50 patients treated at 4 years. However, 30% of the patients needed further treatment for their BPH. TUMT is safe and effective in patients not wanting anaesthesia and in young patients concerned about retrograde ejaculation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microwave thermotherapy: a long‐term follow‐up of 67 patients from a single centre

Glass

Bdesha

Witherow

1998

British Journal of Urology

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“…Additionally, re-treatment rates have been shown to be as high as 50%, calling into question the durability of treatment. [18][19][20][21][22][23] BPH Continuum of Care: Bladder Health…”

Section: Bph Surgical Proceduresmentioning

confidence: 99%

Optimizing Population Health and Economic Outcomes: Innovative Treatment for BPH

Janice¹

2013

Population Health Management

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“…imum urinary flow rate (Q max ) and statistically significantly QoL scores in patients with BPH [26][27][28][29][30][31]. In a recent study of 70 patients who underwent targeted TUMT, improvements of more than 50% in the IPSS, Q max and QoL scores were achieved in 74, 71 and 79% of patients, respectively [32].…”

Section: The Concept Of Tumtmentioning

confidence: 99%

Transurethral microwave thermotherapy for treatment of benign prostatic hyperplasia

Waldert¹,

Djavan²

2004

The Journal of Men's Health & Gender

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Many urologists have a high regard for the usefulness of transurethral microwave therapy (TUMT) in treating patients with lower urinary tract symptoms caused by benign prostatic hyperplasia. This therapy has been examined clinically in many centers throughout the world. The rationale for its effect on symptoms is unlike many of the other so-called minimally invasive treatment modalities. The improvement in symptoms and voiding function is greater with transurethral microwave thermotherapy than with drug therapy, and the associated morbidity is low. It also offers greater versatility than drug therapy, allowing patients with severe baseline symptoms and small prostates to be treated successfully. In addition, there has been an evolution in the technology of TUMT from low-energy to high-energy application indicating that this technique has a future in the treatment of lower urinary tract symptoms.

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A Sham Controlled Trial of Transurethral Microwave Therapy with Subsequent Treatment of the Control Group

Cited by 38 publications

References 14 publications

Microwave thermotherapy: a long‐term follow‐up of 67 patients from a single centre

Microwave thermotherapy: a long‐term follow‐up of 67 patients from a single centre

Optimizing Population Health and Economic Outcomes: Innovative Treatment for BPH

Transurethral microwave thermotherapy for treatment of benign prostatic hyperplasia

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