A severe case of olanzapine overdose with analytical data

Ballesteros, Salomé; Martínez, María Antonia; Ballesteros, María Ángeles; Torre, Carolina Sánchez de la; Rodríguez-Borregán, J.C.

doi:10.1080/15563650601072183

Cited by 9 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Olanzapine resembles clozapine both chemically and pharmacologically, although monitoring for agranulocytosis is not required with olanzapine because this effect is much less common (29,30). Overdoses have been characterized by CNS depression and unpredictable fluctuation between sedation and agitation (29,31).…”

Section: Olanzapinementioning

confidence: 98%

See 1 more Smart Citation

Toxicology and Overdose of Atypical Antipsychotics

Minns

Clark

2012

The Journal of Emergency Medicine

View full text Add to dashboard Cite

Section: Olanzapinementioning

confidence: 98%

“…Overdoses have been characterized by CNS depression and unpredictable fluctuation between sedation and agitation (29,31). Olanzapine ingestions have been associated with increased creatine kinase, although the mechanism by which this occurs remains unclear (32).…”

Section: Olanzapinementioning

confidence: 99%

Toxicology and Overdose of Atypical Antipsychotics

Minns

Clark

2012

The Journal of Emergency Medicine

View full text Add to dashboard Cite

“…5,6 Therapy with olanzapine has been linked to the development of myopathy, occasionally associated with massive rises in serum CK. 7 Á 12 Rhabdomyolysis has also been reported in the context of acute olanzapine overdose, 13,14 as have neuroleptic malignant syndrome, 15 Á 18 serotonin syndrome, 19,20 miosis, 5,21 and extrapyramidal disorders. 22 Clinical features of toxicity may persist for up to 24 hours after acute olanzapine ingestion.…”

Section: Introductionmentioning

confidence: 99%

Olanzapine overdose is associated with acute muscle toxicity

Waring¹,

Wrate²,

Bateman

2006

Hum Exp Toxicol

View full text Add to dashboard Cite

Olanzapine is an atypical antipsychotic that is reported to cause myopathy and raised creatine kinase (CK) levels. The prevalence and severity of acute myopathy after deliberate olanzapine ingestion are unclear. Therefore, we reviewed casenotes from 64 consecutive patients admitted to our institution after olanzapine overdose. Overall, serum CK was higher than five times the upper limit of normal in 17% of patients. The prevalence of raised CK values was positively correlated with the stated quantity of olanzapine ingested, suggesting a dose-dependent relationship for acute muscle toxicity. There was an apparent delay of 12 hours or more between olanzapine ingestion and the occurrence of maximum CK. Despite the high prevalence of acute muscle toxicity after olanzapine ingestion, none of the patients developed renal failure.

show abstract

“…Similar findings were reported by Arora et al ( 7 ), who presented a case of a patient who ingested 1600 mg and required minimal therapy. There are reports of patients surviving and completely recovering from an overdose with 800 mg of olanzapine and serum concentration of 0.991 mg/L or overdosing with 550 mg and 280 mg which led to serum concentrations of 0.815 mg/L and 0.41 mg/l, respectively ( 3 , 18 , 19 , 20 ).…”

Section: Resultsmentioning

confidence: 99%

Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms

Đorđević

Vukčević

Antunović

et al. 2022

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Olanzapine is a thienobenzodiazepine class antipsychotic that strongly antagonises the 5-HT2A serotonin receptor, but acute poisonings are reported rarely. Symptoms of an overdose include disorder of consciousness, hypersalivation, myosis, and coma. Serum concentration higher than 0.1 mg/L is toxic, while concentration above 1 mg/L can be fatal. Here we report key data about 61 patients admitted to the National Poison Control Centre in Belgrade, Serbia over olanzapine poisoning in 2017 and 2018. The ingested doses ranged from 35 to 1680 mg, and time from ingestion to determination from two to 24 hours. In 34 patients olanzapine serum concentrations were in the therapeutic range and in 27 in the toxic range. In five patients they were higher than fatal, but only one patient died. The most common symptoms of poisoning were depressed consciousness (fluctuating from somnolence to coma), tachycardia, hypersalivation, hypotension, myosis, and high creatine kinase. All patients but one recovered fully after nonspecific detoxification and symptomatic and supportive therapy.

show abstract

A severe case of olanzapine overdose with analytical data

Abstract: This study reports an acute olanzapine monointoxication with severe toxicity and high whole blood olanzapine concentrations. Clinical and analytical data of similar samples obtained in non-fatal life-threatening cases can be very useful when interpreting postmortem cases.

Cited by 9 publications

References 25 publications

Toxicology and Overdose of Atypical Antipsychotics

Toxicology and Overdose of Atypical Antipsychotics

Olanzapine overdose is associated with acute muscle toxicity

Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms

Contact Info

Product

Resources

About