A seven-immune-genes risk model predicts the survival and suitable treatments for patients with skin cutaneous melanoma

Lin, Xixi; Hessenow, Razan; Yang, Siling; Ma, Dongjie; Yang, Sijie

doi:10.1016/j.heliyon.2023.e20234

Cited by 1 publication

(1 citation statement)

References 48 publications

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“…Through these mechanisms, HAPLN3 fosters the progression of ccRCC and may serve as a potential therapeutic target [114]. HAPLN3 has been proposed as a marker to predict survival and optimise the treatment of cutaneous melanoma [261]. Several pyroptosis-associated genes including HAPLN3 were highly associated with immune infiltration, immune checkpoints, treatment responses, immunoinflammatory response which have been used to evaluate immunity in the TME of cutaneous melanoma [262].…”

Section: Haim and Immunity In Cancermentioning

confidence: 99%

Hyaluronic Acid Interacting Molecules Mediated Crosstalk between Cancer Cells and Microenvironment from Primary Tumour to Distant Metastasis

Xu,

Benedikt,

2024

Cancers

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Hyaluronic acid (HA) is a prominent component of the extracellular matrix, and its interactions with HA-interacting molecules (HAIMs) play a critical role in cancer development and disease progression. This review explores the multifaceted role of HAIMs in the context of cancer, focusing on their influence on disease progression by dissecting relevant cellular and molecular mechanisms in tumour cells and the tumour microenvironment. Cancer progression can be profoundly affected by the interactions between HA and HAIMs. They modulate critical processes such as cell adhesion, migration, invasion, and proliferation. The TME serves as a dynamic platform in which HAIMs contribute to the formation of a unique niche. The resulting changes in HA composition profoundly influence the biophysical properties of the TME. These modifications in the TME, in conjunction with HAIMs, impact angiogenesis, immune cell recruitment, and immune evasion. Therefore, understanding the intricate interplay between HAIMs and HA within the cancer context is essential for developing novel therapeutic strategies. Targeting these interactions offers promising avenues for cancer treatment, as they hold the potential to disrupt critical aspects of disease progression and the TME. Further research in this field is imperative for advancing our knowledge and the treatment of cancer.

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Section: Haim and Immunity In Cancermentioning

confidence: 99%