A SERS active bimetallic core–satellite nanostructure for the ultrasensitive detection of Mucin-1

Feng, Jingjing; Wu, Xiaoling; Ma, Wei; Kuang, Hua; Xu, Liguang

doi:10.1039/c5cc05255f

Cited by 97 publications

(65 citation statements)

References 29 publications

(53 reference statements)

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“…as SERS-encoded tags, 8,9 cellular imaging, 10 or biomarker detection. 11 Strategies for high SERS brightness include spiky 12 and undulated particle surfaces, 13,14 as well as cluster-encasing 15 and multilayer adsorption 16 of smaller particles on a central core NP. Assemblies consisting of a larger core NP surrounded by a monolayer of smaller NPs are commonly referred to as core/ satellite superstructures.…”

Section: Introductionmentioning

confidence: 99%

SERS and plasmonic heating efficiency from anisotropic core/satellite superstructures

et al. 2019

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Section: Introductionmentioning

confidence: 99%

SERS and plasmonic heating efficiency from anisotropic core/satellite superstructures

et al. 2019

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“…9 The sensitivity of DNA-driven, self-assembling nanopyramids with a Raman reporter or aptamer-based, surface-enhanced Raman scattering sensors can push the sensitivity of biomarker assays to an attomolar range. 40–43 Basically, assays can be tailor-made to measure biomarkers in concentration ranges of biologic importance with suitably functionalized transducers.…”

Section: Resultsmentioning

confidence: 99%

Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors

Luan²,

Kharasch

et al. 2016

ACS Appl. Mater. Interfaces

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Natural antibodies used as biorecognition elements suffer from numerous shortcomings, such as limited chemical and environmental stability and cost. Artificial antibodies based on molecular imprinting are an attractive alternative to natural antibodies. We investigated the role of aromatic interactions in target recognition capabilities of artificial antibodies. Three proteins with different aromatic amino acid content were employed as model targets. Artificial antibodies were formed on nanostructures using combinations of silane monomers of varying aromatic functionality. We employed refractive index sensitivity of plasmonic nanostruc-tures as a transduction platform for monitoring various steps in the imprinting process and to quantify the target recognition capabilities of the artificial antibodies. The sensitivity of the artificial antibodies with aromatic interactions exhibited a protein-dependent enhancement. Selectivity and sensitivity enhancement due to the presence of aromatic groups in imprinted polymer matrix was found to be higher for target proteins with higher aromatic amino acid content. Our results indicate that tailoring the monomer composition based on the amino acid content of the target protein can improve the sensitivity of plasmonic biosensors based on artificial antibodies without affecting the selectivity.

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“…The SERS effects of the nanoparticle-based nanostructures can be optimized by controlling the gaps between adjacent nanoparticles through coating Ag shells around the nanoparticles 12–14 . In addition, when a DNA aptamer is used as a linker to attach two nanoparticles, an analyte-controllable SERS hot spot at the nanogap between the nanoparticles can be created 28,35–37 .…”

Section: Introductionmentioning

confidence: 99%

“…Some other studies used core-satellite nanostructures for enhancing Raman reporter molecules that were placed at the hot spots but not for determining the concentrations of molecules 30,31,33,34,48–50 . Many of the core-satellite nanostructures used for SERS detection of molecules were based on detection schemes that utilized either DNA aptamers and Raman reporter molecules 28,29,36,37,51–53 or certain kinds of chemical interactions 54–56 , but the availability of suitable aptamers and chemical reactions could limit the use of the nanostructures for the detection of other molecules. Some of the SERS substrates formed with core-satellite nanostructures did not have many SERS hot spots in the z-direction, and the density of the nanostructures in the xy-plane was not maximized 14,27,57 .…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional SERS Substrates Formed with Plasmonic Core-Satellite Nanostructures

Wu¹,

Li²,

Lin

et al. 2017

Sci Rep

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We demonstrate three-dimensional surface-enhanced Raman spectroscopy (SERS) substrates formed by accumulating plasmonic nanostructures that are synthesized using a DNA-assisted assembly method. We densely immobilize Au nanoparticles (AuNPs) on polymer beads to form core-satellite nanostructures for detecting molecules by SERS. The experimental parameters affecting the AuNP immobilization, including salt concentration and the number ratio of the AuNPs to the polymer beads, are tested to achieve a high density of the immobilized AuNPs. To create electromagnetic hot spots for sensitive SERS sensing, we add a Ag shell to the AuNPs to reduce the interparticle distance further, and we carefully adjust the thickness of the shell to optimize the SERS effects. In addition, to obtain sensitive and reproducible SERS results, instead of using the core-satellite nanostructures dispersed in solution directly, we prepare SERS substrates consisting of closely packed nanostructures by drying nanostructure-containing droplets on hydrophobic surfaces. The densely distributed small and well-controlled nanogaps on the accumulated nanostructures function as three-dimensional SERS hot spots. Our results show that the SERS spectra obtained using the substrates are much stronger and more reproducible than that obtained using the nanostructures dispersed in solution. Sensitive detection of melamine and sodium thiocyanate (NaSCN) are achieved using the SERS substrates.

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A SERS active bimetallic core–satellite nanostructure for the ultrasensitive detection of Mucin-1

Cited by 97 publications

References 29 publications

SERS and plasmonic heating efficiency from anisotropic core/satellite superstructures

SERS and plasmonic heating efficiency from anisotropic core/satellite superstructures

Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors

Three-Dimensional SERS Substrates Formed with Plasmonic Core-Satellite Nanostructures

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