A serotonin voltammetric biosensor composed of carbon nanocomposites and DNA aptamer

Li, Jingjing; Si, Yunpei; Park, Yae Eun; Choi, Jung Seok; Jung, Sung Mi; Lee, Ji Eun; Lee, Hye Jin

doi:10.1007/s00604-021-04798-x

Cited by 14 publications

(9 citation statements)

References 35 publications

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“…For example, Lee et al 22 developed a voltammetric sensor for 5-HT (Fig. 3) via the layer-by-layer assembly method for incorporating the 5-HT-specific DNA aptamer and tyrosinase (Tyr).…”

Section: Voltammetric Sensing Strategies For Hormonesmentioning

confidence: 99%

“…[44][45][46][47][48] On the other hand, bioaffinity sensors involving antibodies or aptamers have been fabricated to measure the concentrations of DA, 5-HT, T3, and T4 in human serum solutions. 22,29,30,[49][50][51] The integration of such biorecognition elements on an electrode could further improve the selectivity and sensitivity, thus ensuring nanomolar and even picomolar detection (some recent examples are highlighted in Table 1). Further, an antibody functionalized sensor for detecting T3 via the immobilization of anti-T3 on a poly(aniline-4-aminophenol) (4-PANAP) copolymer modified graphite electrode (GE) was demonstrated.…”

Section: Voltammetric Sensors For Amino Acid-derived Hormonesmentioning

confidence: 99%

“…Moreover, bioaffinity sensors integrating aptamers specific to DA and T4 were created to analyze human serum. 22,30,50 A thiolated RNA aptamer and cysteamine functionalized Au electrode coupled with a flow-injection system was described for DA sensing in undiluted human serum and blood samples. 50 During the flow-injection process, DA interacted with the aptamer on the electrode whereas the undesired molecules were washed away, thereby significantly reducing nonspecific adsorption.…”

Section: Voltammetric Sensors For Amino Acid-derived Hormonesmentioning

confidence: 99%

“…An alternative detection strategy for amino acid-derived hormones involves a biocatalytic sensing platform using Tyr, which is commonly used due to its catalytic property that is relatively specific to phenolic compounds, to analyze DA, EP, and 5-HT. 22,49,52 A Tyr and ZnO-rGO coated ITO electrode was developed to selectively determine DA concentration with an ultralow LOD of 8.75 pM. 49 Herein, ZnO-rGO behaved as an immobilization matrix, which could be further covalently linked to Tyr via EDC/NHS linker, making LOD three orders of magnitudes lower than those previously discussed for the direct oxidation method using AuNBP-MWCNTs 34 and Fe2O3/ErGO 35 GCEs.…”

Section: Voltammetric Sensors For Amino Acid-derived Hormonesmentioning

confidence: 99%

Section: Figure Captionsmentioning

confidence: 99%

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Recent research trends in voltammetric sensing platforms for hormones and their applications to human serum analyses

Jhung

et al. 2022

ANAL. SCI.

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Hormones are essential chemical messengers that modulate body homeostasis and regulate appetite, mood, reproduction, and metabolism in the human body. Its dysregulation in the body can cause diabetes, Alzheimer's disease, and autism. The detection of hormone levels in biological fluids, including serum samples, could facilitate the precaution, diagnosis, and cure of diseases. Voltammetric sensing devices exhibiting significant sensitivity, selectivity, as well as facile, cost-effective fabrication, is a promising method for detecting hormone levels. Thus, this review briefly highlights recent advances toward developing voltammetric sensors for a wide spectrum of amino acid-derived, peptide, and lipid-derived hormones alongside their applications to the analyses of human serum samples. Further, several challenging issues and the prospects of voltammetric hormone sensing devices in clinical diagnostic applications are discussed.

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“…For example, Lee et al 22 developed a voltammetric sensor for 5-HT (Fig. 3) via the layer-by-layer assembly method for incorporating the 5-HT-specific DNA aptamer and tyrosinase (Tyr).…”

Section: Voltammetric Sensing Strategies For Hormonesmentioning

confidence: 99%

Section: Voltammetric Sensors For Amino Acid-derived Hormonesmentioning

confidence: 99%

Section: Voltammetric Sensors For Amino Acid-derived Hormonesmentioning

confidence: 99%

Section: Voltammetric Sensors For Amino Acid-derived Hormonesmentioning

confidence: 99%

Section: Figure Captionsmentioning

confidence: 99%

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Recent research trends in voltammetric sensing platforms for hormones and their applications to human serum analyses

Jhung

et al. 2022

ANAL. SCI.

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A liquid crystal‐based sensor exploiting the aptamer‐mediated recognition at the aqueous/liquid crystal interface for sensitive detection of serotonin

Ryu

Jang

2023

Biotech and App Biochem

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We report here a liquid crystal (LC)‐based sensor for detecting serotonin (5‐HT); the proposed sensor uses target‐specific aptamer recognition at a cationic surfactant decorated‐aqueous/LC interface. Our detection strategy focuses on the orientational transition of LCs upon biological interactions at the interface. In this sensing system, the cationic surfactant hexadecyltrimethylammonium bromide (CTAB) forms a self‐assembled monolayer at the aqueous/LC interface and triggers the homeotropic orientation of LCs. After introducing the 5‐HT specific aptamer, an electrostatic attraction occurs between the cationic CTAB and anionic aptamer. This interaction destructs the surfactant monolayer at the interface, inducing reorganization of LC alignment from homeotropic to tilted conditions. In the increasing 5‐HT levels, specific binding between 5‐HT and the aptamer diminishes the interaction between the aptamer and CTAB, thereby maintaining the homeotropic alignment of LCs. The orientational transition of the LCs was observed under a polarized optical microscope. The developed biosensor has a linear detection range from 1 to 1000 nM and a detection limit of 1.68 nM. Moreover, the sensor was applied to a human urine sample and a detection limit of 2.25 nM was obtained. Overall, the designed LC‐based sensor is a sensitive, simple, cost effective, and selective platform for detecting 5‐HT in aqueous solutions.

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Bimetallic nickel iron zeolitic imidazolate fibers as biosensing platform for neurotransmitter serotonin

et al. 2022

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A serotonin voltammetric biosensor composed of carbon nanocomposites and DNA aptamer

Cited by 14 publications

References 35 publications

Recent research trends in voltammetric sensing platforms for hormones and their applications to human serum analyses

Recent research trends in voltammetric sensing platforms for hormones and their applications to human serum analyses

A liquid crystal‐based sensor exploiting the aptamer‐mediated recognition at the aqueous/liquid crystal interface for sensitive detection of serotonin

Bimetallic nickel iron zeolitic imidazolate fibers as biosensing platform for neurotransmitter serotonin

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