A seroprevalence and relationship survey of brucellosis between pregnant women and women with spontaneous abortion in Iran

Ahmadi, Amjad; Mohsenpour, Behzad; Doroudian, Pari; Mokarizadeh, Aram; Roshani, Daem; Shahgheibi, Sholeh; Zandvakili, Farnaz; Farhadifar, Fariba; Seyedoshohadaei, Fariba

doi:10.14196/mjiri.31.42

Cited by 6 publications

(8 citation statements)

References 12 publications

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“…The reasons might be that most of these pregnant women had taken proper precautions to avoid brucellosis during pregnancy. A study conducted in Iran in pregnant women reported the history of spontaneous abortion to be 19.9% [ 42 ]. Another study conducted by Elshamy and Ahmed in Saudi Arabia recorded a 27.2% spontaneous abortion rate in seropositive pregnant women, showing a relationship between brucellosis and abortion [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Serosurvey and Risk Factors Associated with Brucella Infection in High Risk Occupations from District Lahore and Kasur of Punjab, Pakistan

et al. 2021

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Brucellosis is a neglected zoonotic disease, and occupations with a high risk of infection exist. Limited information is available on brucellosis for these employees at high risk in Pakistan. A total of 459 persons with high-risk occupations, i.e., 211 abattoir workers, 63 milkers, 52 dung cake makers, 44 veterinarians, 44 shepherds, and 45 veterinary students of the districts Kasur and Lahore, Pakistan, were tested in this study. Blood samples and information on place of residence, gender, age, urbanicity, type of occupation, socioeconomic status, contact with animals, consumption of raw milk, contact to women who had a miscarriage, contact to aborted animal fetus or abortion material, pregnancy, miscarriage history, or intrauterine fetal death were collected. Serum samples were examined using Rose Bengal tests for anti-Brucella antibodies and seropositive samples were subjected to genus-specific qPCR for the detection of DNA. Data were analyzed using chi-squared and binary regression. Twenty (4.35%) persons were seropositive for anti-Brucella antibodies. Out of these, 18 (90%) were tested positive by Brucella genus-specific qPCR. Positive sera were more often found in Lahore district (8.3%) than in Kasur district (3.1%). Persons older than 36 years were more often seropositive. Persons involved in the handing of milk and in contact with animals were more often seropositive. Contact with women who had had a miscarriage was also a significant factor for seropositivity for brucellosis. Place of residence, gender, age, urbanicity, and contact with animals were identified as potential risk factors in the present study. The present study confirmed that brucellosis is an occupation hazard for abattoir workers, milkers, dung cake makers, and veterinarians in the districts of Lahore and Kasur of Punjab, Pakistan. The study shows the need for strategies for safety at work to minimize the risk of infection. Raising awareness for the prevention and use of proper personal protection equipment during the slaughtering and treatment of animal is highly needed.

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Section: Discussionmentioning

confidence: 99%

Serosurvey and Risk Factors Associated with Brucella Infection in High Risk Occupations from District Lahore and Kasur of Punjab, Pakistan

et al. 2021

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“…Spink also did not find definitive evidence that Brucella species produce abortions any more frequently than other bacterial species [ 33 ]. In the same line, several newer studies from endemic regions demonstrated that Brucella seroprevalence among pregnant women with and without a history of spontaneous abortion was similar, i.e., the women with a spontaneous abortion were not more commonly seropositive than those with normal pregnancy outcome [ 18 , 31 , 34 ]. It is important to emphasize that, as a control group in these three studies, the prevalence of abortions among the general population was investigated instead of abortion prevalence among seronegative women.…”

Section: The Influence Of Human Brucellosis On Obstetric Outcomesmentioning

confidence: 99%

Human brucellosis in pregnancy – an overview

Bosilkovski

Arapović

Keramat

2019

Bosn J of Basic Med Sci

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Human brucellosis during pregnancy is characterized by significantly less pronounced adverse obstetric outcomes than in animals, but with remarkably more adverse obstetric outcomes when compared to healthy pregnant women. Seroprevalence of brucellosis in pregnancy and cumulative incidence of brucellosis cases per 1000 delivered obstetrical discharges in endemic regions were reported to be 1.5–12.2% and 0.42–3.3, respectively. Depending on the region, frequency of pregnant women in the cohorts of patients with brucellosis was from 1.5% to 16.9%. The most common and the most dramatic unfavorable outcomes during brucellosis in pregnancy are the obstetric ones, manifested as abortions (2.5–54.5%), intrauterine fetal death (0–20.6%) or preterm deliveries (1.2–28.6%), depending on the stage of pregnancy. Other unfavorable outcomes due to brucellosis are addressed to infant (congenital/neonatal brucellosis, low birth weight, development delay or even death), the clinical course of disease in mother and delivery team exposure. When diagnosed in pregnant women, brucellosis should be treated as soon as possible. Early administration of adequate therapy significantly reduces the frequency of adverse outcomes. Rifampicin in combination with trimethoprim-sulfamethoxazole for 6 weeks is the most commonly used and recommended regimen, although monotherapies with each of these two drugs are also widely used while waiting for the results from prospective randomized therapeutic trials. As no effective human vaccine exists, screening of pregnant women and education of all women of childbearing age about brucellosis should be compulsory preventive measures in endemic regions.

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“…† Detailed in Table 2 high risk of being encountered with brucellosis in these areas. Furthermore, the incidence of pregnant women with brucellosis was 1.5% in the study by Roushan et al, 20 while another study showed that the incidence of pregnant women with brucellosis was 20.6% in Iran, 14 and much higher than the extracted highest incidence (5.8%) of brucellosis occurred in pregnant women in this review. This may be explained by that incidence of human brucellosis was high during these years and there were significant differences in the geographic distribution of brucellosis in Iran.…”

Section: Discussionmentioning

confidence: 42%

“…This may be explained by that incidence of human brucellosis was high during these years and there were significant differences in the geographic distribution of brucellosis in Iran. 14,21 Serum agglutination test (SAT) was the most common laboratory test in the diagnosis of brucellosis in the included studies, indicating its better sensitivity or wider application compared with the culture or PCR. 22 Regarding the clinical manifestations, the pregnant women with brucellosis presented as non-specific flu-like symptoms, and this may cause a huge possibility of misdiagnosis or delayed diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 However, it remains disputed about the relationship between brucellosis and the other adverse outcomes of pregnancy. 14 Also, it is unknown whether brucellosis causes a higher incidence of abortion than the infection of other bacteria. 15 Considering that there were only a few studies concentrating on the clinical manifestations of pregnant women with brucellosis, we reviewed the relevant studies in order to assess the frequency and severity of the clinical manifestations and investigate the main risk factors for pregnant women with brucellosis.…”

Section: Introductionmentioning

confidence: 99%

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<p>Different Clinical Manifestations of Human Brucellosis in Pregnant Women: A Systematic Scoping Review of 521 Cases from 10 Countries</p>

Liu¹,

Wei²,

Li³

et al. 2020

IDR

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Introduction: This systematic scoping review aims to assess the frequency and severity of clinical manifestations of pregnant women with brucellosis. Methods: Three literature databases, PubMed, Web of Science and China National Knowledge Infrastructure (CNKI), and two search engines (Google and Yahoo) were adopted to identify the relevant articles that published until 31 December 2019. Two investigators independently screened the publications and extracted the data; the case reports and case series which described at least two symptoms or clinical manifestations of pregnant women with brucellosis were included. Results: A total of 27 articles describing the information of 521 pregnant women with brucellosis were included. Serum agglutination test was the most common laboratory test in the diagnosis of brucellosis. A total of 36 clinical manifestations were extracted from the included articles, and the most common clinical manifestations were fever (400, 76.8%), joint pain/swelling/arthralgia (389, 74.7%), sweats (382, 73.3%), fatigue/asthenia/weakness (262, 50.3%) and back pain (189, 36.3%). Among the 32 included individual cases that with available obstetric outcome information, 10 (31.3%) suffered preterm delivery, 12 (37.5%) had an abortion and 3 (9.8%) had intrauterine fetal death. Conclusion: Brucellosis is popular and threatening for pregnant women. Regarding the localized body system complications, osteoarticular system was mostly involved, the obstetrics outcomes were severe among pregnant women with brucellosis. The detailed clinical and epidemiological characteristics in this scoping review may add a better and more complete understanding of the disease for both physicians and policy-makers, and provide evidence for timely diagnosis, adequate therapy and better prevention.

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A seroprevalence and relationship survey of brucellosis between pregnant women and women with spontaneous abortion in Iran

Cited by 6 publications

References 12 publications

Serosurvey and Risk Factors Associated with Brucella Infection in High Risk Occupations from District Lahore and Kasur of Punjab, Pakistan

Serosurvey and Risk Factors Associated with Brucella Infection in High Risk Occupations from District Lahore and Kasur of Punjab, Pakistan

Human brucellosis in pregnancy – an overview

<p>Different Clinical Manifestations of Human Brucellosis in Pregnant Women: A Systematic Scoping Review of 521 Cases from 10 Countries</p>

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