A serological survey of SARS-CoV-2 in cat in Wuhan

Zhang, Qiang; Zhang, Huajun; Gao, Jindong; Huang, Kun; Yang, Yong; Hui, Xianfeng; He, Xinglin; Li, Chengfei; Gong, Wenxiao; Zhang, Yufei; Zhao, Ya; Cheng, Peng; Gao, Xiaoxiao; Chen, Huanchun; Zou, Zhong; Shi, Zheng Li; Jin, Meilin

doi:10.1080/22221751.2020.1817796

Cited by 258 publications

(417 citation statements)

References 25 publications

Supporting

Mentioning

365

Contrasting

Unclassified

Order By: Relevance

“…Both virological and serological testing found evidence for natural SARS-CoV-2 infection in two dogs from households with human cases of COVID-19 in Hong Kong, but the dogs appeared asymptomatic 45 . Another serological study detected SARS-CoV-2 neutralizing antibodies in cat serum samples collected in Wuhan after the COVID-19 outbreak, providing evidence for SARS-CoV-2 infection in cat populations in Wuhan, although the potential of SARS-CoV-2 transmission from cats to humans is currently uncertain 46 .…”

Section: Animal Host and Spillovermentioning

confidence: 99%

Characteristics of SARS-CoV-2 and COVID-19

et al. 2020

Self Cite

View full text Add to dashboard Cite

Coronaviruses are a diverse group of viruses infecting many different animals, and they can cause mild to severe respiratory infections in humans. In 2002 and 2012, respectively, two highly pathogenic coronaviruses with zoonotic origin, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), emerged in humans and caused fatal respiratory illness, making emerging coronaviruses a new public health concern in the twenty-first century 1. At the end of 2019, a novel coronavirus designated as SARS-CoV-2 emerged in the city of Wuhan, China, and caused an outbreak of unusual viral pneumonia. Being highly transmissible, this novel coronavirus disease, also known as coronavirus disease 2019 (COVID-19), has spread fast all over the world 2,3. It has overwhelmingly surpassed SARS and MERS in terms of both the number of infected people and the spatial range of epidemic areas. The ongoing outbreak of COVID-19 has posed an extraordinary threat to global public health 4,5. In this Review, we summarize the current understanding of the nature of SARS-CoV-2 and COVID-19. On the basis of recently published findings, this comprehensive Review covers the basic biology of SARS-CoV-2, including the genetic characteristics, the potential zoonotic origin and its receptor binding. Furthermore, we will discuss the clinical and epidemiological features, diagnosis of and countermeasures against COVID-19. Emergence and spread In late December 2019, several health facilities in Wuhan, in Hubei province in China, reported clusters of patients with pneumonia of unknown cause 6. Similarly to patients with SARS and MERS, these patients showed symptoms of viral pneumonia, including fever, cough

show abstract

Section: Animal Host and Spillovermentioning

confidence: 99%

Characteristics of SARS-CoV-2 and COVID-19

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The substitution of E37 with glutamine shifts the electrostatic feature to the opposite and might contribute to the decreased ability of civet ACE2 to interact with SARS-CoV-2 RBD. Multiple evidence supports the susceptibility of cats to SARS-CoV-2, including the cat samples in Wuhan collected after the outbreak circulating the antibodies against SARS-CoV-2 23,32 . In this study, the SARS-CoV-2 RBD is found to interact with the cACE2, albeit with a lower binding affinity than with hACE2.…”

Section: Discussionmentioning

confidence: 94%

“…In addition, cats and ferrets are permissive to SARS-CoV-2 infection and cats experimentally transmit SARS-CoV-2 to naïve cats 22 . Notably, 14.7% (15/102) cat sera collected after the COVID-19 outbreak in Wuhan were positive for the SARS-CoV-2, while 39 cat sera collected prior to the outbreak are negative, demonstrating that SARS-CoV-2 infected the cat population in Wuhan during the outbreak 23 . Despite these reports and suspicions, the real intermediate host for SARS-CoV-2 remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

et al. 2020

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the recent pandemic COVID-19, is reported to have originated from bats, with its intermediate host unknown to date. Here, we screened 26 animal counterparts of the human ACE2 (hACE2), the receptor for SARS-CoV-2 and SARS-CoV, and found that the ACE2s from various species, including pets, domestic animals and multiple wild animals, could bind to SARS-CoV-2 receptor binding domain (RBD) and facilitate the transduction of SARS-CoV-2 pseudovirus. Comparing to SARS-CoV-2, SARS-CoV seems to have a slightly wider range in choosing its receptor. We further resolved the cryo-electron microscopy (cryo-EM) structure of the cat ACE2 (cACE2) in complex with the SARS-CoV-2 RBD at a resolution of 3 Å, revealing similar binding mode as hACE2 to the SARS-CoV-2 RBD. These results shed light on pursuing the intermediate host of SARS-CoV-2 and highlight the necessity of monitoring susceptible hosts to prevent further outbreaks.

show abstract

“…There are two serological surveys with cats, one of which also includes dogs (102). In an unpublished study, 11 of 102 cats had neutralizing antibodies against SARS-CoV-2, suggesting that under natural conditions, cats exposed to SARS-CoV-2 develop antibodies (103). These samples were obtained after the outbreak of COVID-19 in Wuhan, China (103).…”

Section: Discussionmentioning

confidence: 99%

“…In an unpublished study, 11 of 102 cats had neutralizing antibodies against SARS-CoV-2, suggesting that under natural conditions, cats exposed to SARS-CoV-2 develop antibodies (103). These samples were obtained after the outbreak of COVID-19 in Wuhan, China (103). In another serological study also in the Wuhan region, antibodies to SARS-CoV-2 were investigated in 35 animal species (102).…”

Section: Discussionmentioning

confidence: 99%

Natural Infection by SARS-CoV-2 in Companion Animals: A Review of Case Reports and Current Evidence of Their Role in the Epidemiology of COVID-19

et al. 2020

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), is the causative infectious agent of the current pandemic. As researchers and health professionals are still learning the capabilities of this virus, public health concerns arise regarding the zoonotic potential of SARS-CoV-2. With millions of people detected with SARS-CoV-2 worldwide, reports of companion animals possibly infected with the virus started to emerge. Therefore, our aim is to review reported cases of animals naturally infected with SARS-CoV-2, particularly companion pets, shedding light on the role of these animals in the epidemiology of COVID-19.

show abstract

A serological survey of SARS-CoV-2 in cat in Wuhan

Cited by 258 publications

References 25 publications

Characteristics of SARS-CoV-2 and COVID-19

Characteristics of SARS-CoV-2 and COVID-19

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

Natural Infection by SARS-CoV-2 in Companion Animals: A Review of Case Reports and Current Evidence of Their Role in the Epidemiology of COVID-19

Contact Info

Product

Resources

About