A Serological Survey of Akabane Virus Infection in Cattle in Sudan

Elhassan, Amira M.; Mansour, Mohammed E.; Shamon, Awadia A. A.; Hussein, Ahmed S.

doi:10.1155/2014/123904

Cited by 21 publications

(43 citation statements)

References 15 publications

(3 reference statements)

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“…AKAV causes abortions, stillbirths, and congenital disorders in cows, goats, and sheep (Kurogi et al, 1987). AKAV has been detected in Japan, Korea, China, Israel, Australia, Turkey, Sudan, and Kenya (Kurogi et al, 1975;Lee et al, 2002;Jun et al, 2012;Stram et al, 2004;Della-Porta et al, 1976;Taylor and Mellor, 1994;Elhassan et al, 2014;Davies and Jessett, 1985). AKAV belongs to the Simbu serogroup of the genus Orthobunyavirus in the family Bunyaviridae.…”

Section: Introductionmentioning

confidence: 99%

Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis

Mitomo

Omatsu

Tsuchiaka

et al. 2016

Research in Veterinary Science

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Akabane virus (AKAV) belongs to the Simbu serogroup of the genus Orthobunyavirus in the family Bunyaviridae. It has been shown that AKAV induces apoptosis in mammalian cells. It is necessary to understand the signaling pathways involved in AKAV-induced apoptosis to further elucidate the molecular virology of AKAV. c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) are mediators of apoptosis; therefore, we investigated the roles of JNK and p38 MAPK cascades in AKAV-infected cells. We found that JNK and p38 MAPK as well as their downstream substrates, c-Jun and heat shock protein 27 (HSP27), were phosphorylated in response to AKAV infection. A JNK inhibitor (SP600125) inhibited AKAV-mediated apoptosis whereas a p38 MAPK inhibitor (SB203580) did not. We conclude that AKAV infection activates the JNK and p38 MAPK signaling pathways, and the JNK cascade plays a crucial role in AKAV-induced apoptosis in vitro.

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Section: Introductionmentioning

confidence: 99%

Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis

Mitomo

Omatsu

Tsuchiaka

et al. 2016

Research in Veterinary Science

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“…On the contrary, it was significantly higher (P < 0.05) in female compared with male in sheep. This may reflect a higher degree of attractiveness of females to tick vectors (Elhassan et al 2014), but could be due to the continued replacement of males in the farms compared with females so that females were probably exposed to several tick seasons (Palmer et al 1998). In cattle, unlike sheep and goats, seasons seemed to be relevant to seroprevalence of SFG rickettsiae antibodies.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of spotted fever group (SFG) rickettsiae infection in domestic ruminants in Khartoum State, Sudan

et al. 2017

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Spotted fever group (SFG) rickettsiosis is caused by obligatory intracellular Gram‐negative bacteria that belong to the genus Rickettsia. Ticks belonging to the family Ixodidae can act as vectors, reservoirs or amplifiers of SFG rickettsiae. This study was conducted to estimate the seroprevalence of SFG rickettsioses in cattle, sheep and goats from Khartoum State, Sudan. Blood samples were collected from a total of 600 animals (sheep, goats and cattle) from 32 different farms distributed in three locations in Khartoum State during the period January to December 2012. Sera were tested for antibodies against SFG rickettsiae using IFAT. The prevalence of seropositivity was 59.3% in sheep, 60.1% in goats and 64.4% in cattle. Season was significantly (P < 0.05) associated with seroprevalence of SFG rickettsiae in cattle during winter. The SFG rickettsiae antibodies prevalence was significantly higher in female compared with male in sheep, but there were no significant differences between male and female in either cattle or goats. The prevalence was significantly higher in adult animals compared with young in both sheep and goats. With regard to management system, there was a significant difference in the prevalence in cattle raised in closed system compared with those raised in semi‐intensive system. In contrast, there was significant difference in the seroprevalence of SFG in sheep where the prevalence was higher in the sheep raised in semi‐intensive system compared with those raised in close system. There was no significant difference in the seroprevalence in goats with regard to management systems. The unexpected high prevalence of SFG rickettsia antibodies in domestic ruminants sera suggest that the veterinary and public health impact of these agents in Sudan need further evaluation especially in humans.

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“…The incidence of Akabane virus-induced disease is influenced by the species and time of gestation at which infection occurs [29] and by the strain of the virus. Infection in adult cattle has usually no specific signs while infection of pregnant cattle often causes foetal damage, resulting in abortion, stillbirth or various congenital abnormalities [84][85][86]. A distinct tropism for immature rapidly dividing cells of the foetal central nervous system and skeletal muscle results in direct virus-induced necrotizing encephalomyelitis and polymyositis.…”

Section: • Akabane Virusmentioning

confidence: 99%

Epidemiology and Emergence of Schmallenberg Virus Part 1: Origin, Transmission and Differential Diagnosis

Esteves¹,

Mesquita²,

Nóbrega³

et al. 2016

Epidemiology of Communicable and Non-Communicable Diseases - Attributes of Lifestyle and Nature on Humankind

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Schmallenberg virus (SBV) is a novel Orthobunyavirus causing mild clinical signs in cows and malformations in aborted and neonatal ruminants in Europe. SBV belongs to the family Bunyaviridae and is transmitted by biting midges. This new virus was identified for the first time in the blood samples of cows in the city of Schmallenberg in NorthRhine-Westphalia in November 2011. Since then the virus spread to several European countries. Here we describe the origin and emergence, as well as the transmission and the differential diagnosis of this virus, now known to be a serious threat to Veterinary Public Health.

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A Serological Survey of Akabane Virus Infection in Cattle in Sudan

Cited by 21 publications

References 15 publications

Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis

Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis

Seroprevalence of spotted fever group (SFG) rickettsiae infection in domestic ruminants in Khartoum State, Sudan

Epidemiology and Emergence of Schmallenberg Virus Part 1: Origin, Transmission and Differential Diagnosis

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