8Background: Dengue fever is a re-emerging public health threat in Ethiopia. Yet, little is 9 known about the epidemiology and risk factors. In this study the seroprevalence and associated 10 risk factors of dengue virus infection were assessed in Borena Zone health facilities.
11Methods: An institution based cross-sectional study was conducted from May to August, 2016. 12 A total of 519 consecutive acute febrile patients attending the outpatient departments of Teltelle 13 health Center, Yabello and Moyale Hospital were enrolled. Data on socio-demographic and 14 environmental risk factors were collected using structured questionnaire. Three to five milliliter 15 blood samples were collected from all participants and screened for dengue virus exposure using 16 indirect immunofluorescent assay.
17Result: The overall prevalence of anti-DENV IgG and IgM was 22.9% and 7.9% respectively.
18The relatively higher IgM versus IgG, absence of trend with age and little or no correlation with 19 the assessed possible risk factors except being male (AOR=1.72; 95%CI 1.01-2.94), place of 20 residence (AOR=0.37;95%CL 0.21-0.64) that had higher rate of exposure and recall of a recent 21 mosquito bite (AOR=2.98; 95%CI 1.51-5.89) probably imply recent and/or ongoing active 22 transmission.
23Conclusion: This study showed dengue fever could potentially emerge as public health threat in 24 the study area. On top, the observed low awareness of participants underline the urgent need for 25 further systematic studies to determine the environmental, and host factors that determine the 26 extent of exposure to dengue virus infection in the area for appropriate control and prevention 27 planning. 28 Author summary 30 Dengue fever is a mosquito-borne viral disease of global health problem where Aedes aegypti 31 mosquitoes are the main vector. It is endemic in most tropical and sub-tropical countries with an 32 estimated 96 million infections resulting in clinical disease annually. It is unrecognized and 33 underreported in Africa, particularly in Ethiopia. So, the current study were conducted among 34 febrile patients who were attending health institutions to document seroprevalence and 35 associated risk factors of DENV infection in the southern part of the country. The study stated 36 the presence of antibodies against DENV infection in study areas, the ringing bell message for 37 those who were involved in health sectors. Gender and residence were significantly associated 38 with the prevalence of anti-DENV IgG seropositivity. In addition, individuals who have 39 experience of recent mosquito bite were identified as the risk factors of DENV infection. 40 Therefore, I recommend that preventive measures should be considered and nationwide 41 surveillance should be carried out at nationwide. 42 Introduction 43 Dengue fever (DF) is the most rapidly spreading mosquito-borne disease and the major public 44 health problem on the world [1]. Dengue is a viral disease caused by dengue virus serotypes 45 (DENV1-4) of the genus Flavivirus. Dengu...