2023
DOI: 10.1021/acs.inorgchem.3c00753
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A Series of Non-Oxido VIVComplexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity

Abstract: A series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1–4)2] (1–4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1–4, are reported. All the synthesized non-oxido VIV compounds are characterized by elemental analysis, spectroscopy (IR, UV–vis, and EPR), ESI-MS, as well as electrochemical techniques (cyclic voltammetry). Single-crystal X-ray diffraction studies of 1–3 reveal that the mononuclear non-oxido VIV complexes show distorted octahedral (1 a… Show more

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Cited by 8 publications
(3 citation statements)
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References 150 publications
(299 reference statements)
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“…3–6 Non-innocent Schiff base vanadium-catecholates (V-catecholates) have interesting electronic properties with the potential for redox taking place not only on the metal center but also on the ligand. 3,7–9 The subclass of non-innocent Schiff base V-catecholates have recently been discovered to have desirable pharmaceutical properties 3–6,8–16 which has expanded the knowledge on anti-diabetic and anti-cancer properties of vanadium complexes. 3,4,6,8–18 The reported antiproliferative properties of the class of non-innocent Schiff base V-catecholates were reported to surpass the efficacy of cisplatin in human chondrosarcoma (SW1353) bone cells, T98G glioblastoma cells, aggressive mesenchymal-like MDA-MB-231 cells, A549 (lung) and PANC-1 (pancreas) cancer cell lines, and HFF-1 (human foreskin fibroblasts) normal cells.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…3–6 Non-innocent Schiff base vanadium-catecholates (V-catecholates) have interesting electronic properties with the potential for redox taking place not only on the metal center but also on the ligand. 3,7–9 The subclass of non-innocent Schiff base V-catecholates have recently been discovered to have desirable pharmaceutical properties 3–6,8–16 which has expanded the knowledge on anti-diabetic and anti-cancer properties of vanadium complexes. 3,4,6,8–18 The reported antiproliferative properties of the class of non-innocent Schiff base V-catecholates were reported to surpass the efficacy of cisplatin in human chondrosarcoma (SW1353) bone cells, T98G glioblastoma cells, aggressive mesenchymal-like MDA-MB-231 cells, A549 (lung) and PANC-1 (pancreas) cancer cell lines, and HFF-1 (human foreskin fibroblasts) normal cells.…”
Section: Introductionmentioning
confidence: 99%
“…3,7–9 The subclass of non-innocent Schiff base V-catecholates have recently been discovered to have desirable pharmaceutical properties 3–6,8–16 which has expanded the knowledge on anti-diabetic and anti-cancer properties of vanadium complexes. 3,4,6,8–18 The reported antiproliferative properties of the class of non-innocent Schiff base V-catecholates were reported to surpass the efficacy of cisplatin in human chondrosarcoma (SW1353) bone cells, T98G glioblastoma cells, aggressive mesenchymal-like MDA-MB-231 cells, A549 (lung) and PANC-1 (pancreas) cancer cell lines, and HFF-1 (human foreskin fibroblasts) normal cells. The efficacy of these molecules elicited proposals for intratumoral injections 19 as a viable treatment because their potential properties enable intact complexes for cellular uptake which then hydrolyze over time into much less toxic components.…”
Section: Introductionmentioning
confidence: 99%
“…Gathering the knowledge from the above discussion and expertise from our earlier research works on the development of metal-based anticancer agents, , herein, a series of new titanium­(IV)-hydrazone-based complexes ( 1 – 3 ) were reported and characterized by different physicochemical techniques. In this study, two units of dianionic tridentate ligands were purposefully implemented with the intention of achieving maximum hydrolytic stability of 1 – 3 in aqueous media.…”
Section: Introductionmentioning
confidence: 99%