A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center

Kim, Daniel H.; Murovic, Judith A.; Tiel, Robert L.; Moes, Gregory; Kline, David G.

doi:10.3171/jns.2005.102.2.0246

Cited by 283 publications

(274 citation statements)

References 40 publications

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“…The majority of the tumors were reported as benign peripheral nerve sheath tumors from the brachial plexus region. Neurofibromas were more prevalent in the upper extremities [5]. In a series of 40 neural sheath tumors Lusk et al [6] found 26 neurofibromas, nine of which were associated with von Recklinghausen's disease (VRD).…”

Section: Discussionmentioning

confidence: 99%

“…Intraoperative electrophysiological neuromonitoring is used to demonstrate the proper management of a brachial plexus nerve sheath tumor excision [10]. Despite aggressive limb ablation or limb sparing surgery plus adjunctive therapy, malignant peripheral nerve sheath tumors continues to be associated with high morbidity and mortality rates [5].…”

Section: Discussionmentioning

confidence: 99%

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“Huge Axillary Mass - Neurofibroma Brachial Plexus”

2011

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Axillary swelling arising from soft tissue is not uncommon. Lipoma, Lymphadenopathy due to Kochs or Lymphoma are commonest swellings seen but firm to hard non tender mass arising from maninges of Brachial plexus is not so common. Usually these masses are benign but one may come across malignant tumour. Twenty-three year male presented with mass in anterior chest wall & arm pit having no other specific complaints, was diagnosed as Spindle cell tumour on FNAC & excision biopsy turned out to be Neurofibroma of Brachial plexus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“Huge Axillary Mass - Neurofibroma Brachial Plexus”

2011

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“…Multifocal MPNST without neurofibromatosis is a rare occurrence, although a few instances have been reported in literature. Despite aggressive limb ablation or limb sparing surgery and adjunctive therapy MPNSTs continue to be associated with high morbidity and mortality [3].…”

Section: Introductionmentioning

confidence: 99%

Sporadic Multifocal Malignant Peripheral Nerve Sheath Tumor—A Rare Presentation

2011

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Malignant peripheral nerve sheath tumors(MPNST) are uncommon neoplasms with an incidence of 0.001% in general population. Multifocality is a rare manifestation of MPNST . A case of a 65 year old patient who presented with multiple swellings involving the neck, extremity and back without associated neurofibromatosis is reported for its rarity of presentation.. Diagnosis was made by FNAC and confirmed by peroperative findings and histopathology.

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“…1,5 Intraoperative electrical stimulation of motor nerve fascicles and direct recording allow the surgeon to identify involved and nearby functional nerves and avoid damaging them during tumor resection. 3 With a negative electrical map over the surface of the mass, the tumor capsule can be safely entered and the tumor resected without violating or damaging functional nerve fibers.…”

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confidence: 99%

“…3,10 Intraneural tumors may involve 1 or multiple nerve fascicles and may originate from deep within the nerve subsequently splaying apart fascicles as the tumor expands, or they may be attached to a superficial fascicle and thereby displacing the remainder of the nerve to one direction.…”

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confidence: 99%

Visualization of nerve fibers and their relationship to peripheral nerve tumors by diffusion tensor imaging

Cage¹,

Yuh

Hou

et al. 2015

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OBJECT The majority of growing and/or symptomatic peripheral nerve tumors are schwannomas and neurofibromas. They are almost always benign and can usually be resected while minimizing motor and sensory deficits if approached with the proper expertise and techniques. Intraoperative electrophysiological stimulation and recording techniques allow the surgeon to map the surface of the tumor in an effort to identify and thus avoid damaging functioning nerve fibers. Recently, MR diffusion tensor imaging (DTI) techniques have permitted the visualization of axons, because of their anisotropic properties, in peripheral nerves. The object of this study was to compare the distribution of nerve fibers as revealed by direct electrical stimulation with that seen on preoperative MR DTI. METHODS The authors conducted a retrospective chart review of patients with a peripheral nerve or nerve root tumor between March 2012 and January 2014. Diffusion tensor imaging and intraoperative data had been prospectively collected for patients with peripheral nerve tumors that were resected. Preoperative identification of the nerve fiber location in relation to the nerve tumor surface as seen on DTI studies was compared with the nerve fiber’s intraoperative localization using electrophysiological stimulation and recordings. RESULTS In 23 patients eligible for study there was good correlation between nerve fiber location on DTI and its anatomical location seen intraoperatively. Diffusion tensor imaging demonstrated the relationship of nerve fibers relative to the tumor with 95.7% sensitivity, 66.7% specificity, 75% positive predictive value, and 93.8% negative predictive value. CONCLUSIONS Preoperative DTI techniques are useful in helping the peripheral nerve surgeon to both determine the risks involved in resecting a nerve tumor and plan the safest surgical approach.

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A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center

Cited by 283 publications

References 40 publications

“Huge Axillary Mass - Neurofibroma Brachial Plexus”

“Huge Axillary Mass - Neurofibroma Brachial Plexus”

Sporadic Multifocal Malignant Peripheral Nerve Sheath Tumor—A Rare Presentation

Visualization of nerve fibers and their relationship to peripheral nerve tumors by diffusion tensor imaging

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