A Sequentially Activated Probe for Imaging of Superoxide Anion and Peroxynitrite in PC12 Cells under Oxidative Stress
Ying Li,
Jing Cao,
Xue Wu
et al.
Abstract:Superoxide anion (O 2 •− ) and peroxynitrite (ONOO − ), two important oxidants under oxidative stress, coexist in complex cell and organism systems, playing crucial roles in various physiological and pathological processes, particularly in neurodegenerative diseases. Despite the absence of robust molecular tools capable of simultaneously visualizing O 2•− and ONOO − in biosystems, the relationship between these two species remains understudied. Herein, we present sequentially activated fluorescent probe, DHX-S… Show more
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