A sensitive photoelectrochemical biosensor for AFP detection based on ZnO inverse opal electrodes with signal amplification of CdS-QDs

Xu, Ru; Jiang, Yanqiu; Xia, Lei; Zhang, Tianxiang; Xu, Lin; Zhang, Shuang; Liu, Dali; Song, Hongwei

doi:10.1016/j.bios.2015.06.037

Cited by 118 publications

(33 citation statements)

References 44 publications

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“…Recently, electrochemical immunoassay techniques have attracted scientific interest because of the reasons such as molecular recognition between antigen and antibody, simplicity, low cost, great sensitivity and fast analytical time. These properties are fundamental to the exploration of immunosensors for the detection of various cancer biomarkers which include carcinoembryonic antigen , prostate‐specific antigen , immunoglobulin G and alpha‐feto protein to name a few. Hence, the biomarker of interest in this study is alpha‐feto protein.…”

Section: Introductionmentioning

confidence: 99%

A Dendrimer Supported Electrochemical Immunosensor for the Detection of Alpha‐feto protein – a Cancer Biomarker

2017

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The electrochemical detection of alpha-feto protein based on novel gold nanoparticles-poly(propylene imine) dendrimer platform is reported. The platform was prepared by co-electrodeposition of gold nanoparticles and generation 3 poly (propylene imine) dendrimer on a glassy carbon electrode. Each modifying step was characterised by cyclic voltammetry and electrochemical impedance spectroscopy. The electrochemical measurements showed that the platform was stable, conducting and exhibited reversible electrochemistry. Results obtained from the electrochemical impedance spectroscopy interrogation in [Fe(CN) 6 3À/4À] redox probe showed a marked reduction in charge transfer resistance (R ct ) after each modification step. The immunosensor was prepared by immobilisation of a probe anti-alpha feto protein (AFP) on the platform for 3 hrs at 35 8C followed by blocking the surface with bovine serum albumin to minimise nonspecific binding. The prepared immunosensor was used to detect AFP over a wide concentration range from 0.005 to 500 ng/mL and detection limits of 0.0022 and 0.00185 ng/ mL were obtained for SWV and EIS measurements respectively. The immunosensor gave good stability over a period of fourteen days when stored at 4 8C.

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Section: Introductionmentioning

confidence: 99%

A Dendrimer Supported Electrochemical Immunosensor for the Detection of Alpha‐feto protein – a Cancer Biomarker

2017

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“…Furthermore, its excellent thermal, chemical, low density, good biological compatibility and excellent photochemical stability3031 make it attractive in PEC bioanalysis3233. Many ZnO nanostructures, such as nanorods29, nanotubes34, nanowires11, nanosheets35 and nanoflowers36, have been applied in biosensor.…”

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confidence: 99%

Photoelectrochemical detection of alpha-fetoprotein based on ZnO inverse opals structure electrodes modified by Ag2S nanoparticles

Jiang

Liu

Yang

et al. 2016

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In this work, a new photoelectrochemical biosensor based on Ag2S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag2S NPs were prepared using the Successive Ionic Layer Adsorption And Reaction (SILAR) method, which were adsorbed on ZnO IOs surface and frame work as matrix for immobilization of AFP. The composite structure of ZnO/Ag2S expanded the scope of light absorption to long wavelength, which can make full use of the light energy. Meanwhile, an effective matching of energy levels between the conduction bands of Ag2S and ZnO are beneficial to the photo-generated electrons transfer. The biosensors based on FTO (fluorine-doped tinoxide) ZnO/Ag2S electrode showed enough sensitivity and a wide linear range from 0.05 ng/mL to 200 ng/mL with a low detection limit of 8 pg/mL for the detection of AFP. It also exhibited high reproducibility, specificity and stability. The proposed method was potentially attractive for achieving excellent photoelectrochemical biosensor for detection of other proteins.

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“…On the other hand, the 3D inverse opal photonic crystals (IOPCs) possess a unique porous structure, which can provide high specific surface area and many active sites (Figure c) thus to benefit the immobilization of QDs and the shortening of charge transport distance between QDs. More importantly, the photonic stop band effect of IOPCs would effectively increase the optical path length and the interaction between QDs and the excitation light, thus resulting in the enhanced photoresponse signals for PEC sensors . With these considerations in mind, Chen et al designed and fabricated the CsPbBr 1.5 I 1.5 QDs/TiO 2 IOPCs photoelectrode, in which the CsPbBr 1.5 I 1.5 QDs were used as the photoactive material whereas the 3D TiO 2 IOPCs were employed as the support and charge collector (Figure d).…”

Section: Photoelectrochemical Applications Of Ihpqdsmentioning

confidence: 99%

Recent Progress and Development in Inorganic Halide Perovskite Quantum Dots for Photoelectrochemical Applications

Liang

Chen

Yao

et al. 2019

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Inorganic halide perovskite quantum dots (IHPQDs) have recently emerged as a new class of optoelectronic nanomaterials that can outperform the existing hybrid organometallic halide perovskite (OHP), II–VI and III–V groups semiconductor nanocrystals, mainly due to their relatively high stability, excellent photophysical properties, and promising applications in wide‐ranging and diverse fields. In particular, IHPQDs have attracted much recent attention in the field of photoelectrochemistry, with the potential to harness their superb optical and charge transport properties as well as spectacular characteristics of quantum confinement effect for opening up new opportunities in next‐generation photoelectrochemical (PEC) systems. Over the past few years, numerous efforts have been made to design and prepare IHPQD‐based materials for a wide range of applications in photoelectrochemistry, ranging from photocatalytic degradation, photocatalytic CO2 reduction and PEC sensing, to photovoltaic devices. In this review, the recent advances in the development of IHPQD‐based materials are summarized from the standpoint of photoelectrochemistry. The prospects and further developments of IHPQDs in this exciting field are also discussed.

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A sensitive photoelectrochemical biosensor for AFP detection based on ZnO inverse opal electrodes with signal amplification of CdS-QDs

Cited by 118 publications

References 44 publications

A Dendrimer Supported Electrochemical Immunosensor for the Detection of Alpha‐feto protein – a Cancer Biomarker

A Dendrimer Supported Electrochemical Immunosensor for the Detection of Alpha‐feto protein – a Cancer Biomarker

Photoelectrochemical detection of alpha-fetoprotein based on ZnO inverse opals structure electrodes modified by Ag2S nanoparticles

Recent Progress and Development in Inorganic Halide Perovskite Quantum Dots for Photoelectrochemical Applications

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