A sensitive DNA sensor based on an organic electrochemical transistor using a peptide nucleic acid-modified nanoporous gold gate electrode

Tao, Wenyan; Lin, Peng; Hu, Jin; Ke, Shanming; Jia, Song; Zeng, Xierong

doi:10.1039/c7ra09832d

Cited by 30 publications

(12 citation statements)

References 33 publications

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“…In OECTs, ions from an electrolyte penetrate a conjugated polymer network and modulate the conductivity through intricate ion–electron coupling . Owing to their high transconductance and thus ability to amplify small chemical signals with high sensitivity, OECTs are especially promising for diverse biomedical applications such as the detection of ions, , metabolites, , alcohol, DNA, , and cells. − Additionally, they can be fabricated by facile solution and printing processes that allow low-cost and large-area fabrication.…”

Section: Introductionmentioning

confidence: 99%

Self-Healable Organic Electrochemical Transistor with High Transconductance, Fast Response, and Long-Term Stability

Surendran

et al. 2020

ACS Appl. Mater. Interfaces

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The major challenges in developing self-healable conjugated polymers for organic electrochemical transistors (OECTs) lie in maintaining good mixed electronic/ionic transport and the need for fast restoration to the original electronic and structural properties after the selfhealing process. Herein, we provide the first report of an all solid state OECT that is selfhealable and possess good electrical performance, by utilizing a matrix of poly(3,4ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and non-ionic surfactant, Triton X-100 as channel, and ion conducting poly(vinyl alcohol) hydrogel as a quasi-solid-state polymer electrolyte. The fabricated OECT exhibits high transconductance (maximum 54 mS), on/off current ratio of ~1.5×10 3 , fast response time of 6.8 ms and good operational stability after 68 days of storage. Simultaneously, the OECT showed remarkable self-healing and ion-sensing behaviors and recovered ~95% of its ion sensitivity after healing. These findings will contribute to the development of high performing and robust OECTs for wearable bioelectronic devices.

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Section: Introductionmentioning

confidence: 99%

Self-Healable Organic Electrochemical Transistor with High Transconductance, Fast Response, and Long-Term Stability

Surendran

et al. 2020

ACS Appl. Mater. Interfaces

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“…Because PEDOT:PSS is in direct contact with an electrolyte, OECTs can sensitively convert (bio)chemical signals into electronic ones, which make them particularly suitable for chemical and biological detection. Moreover, OECT devices combine several attractive advantages, like ease of fabrication, compatibility with flexible substrates, low operating voltage (<1 V), signal amplification and high transconductance, thereby having broad applications in ions [1], glucose [2,3,4,5], bacteria [6], dopamine [7,8,9], DNA [10,11], lactate [12], cell activities [13,14,15], and electrophysiological signals [16,17]. Of particular interest is the factor that a reference electrode is not necessary when used, and this feature is very important for wearable and textile sensors [18,19,20].…”

Section: Introductionmentioning

confidence: 99%

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Liao

Zhang

et al. 2019

Sensors

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Organic electrochemical transistors (OECTs) are promising devices for applications in in vitro and in vivo measurements. OECTs have two important sensing interfaces for signal monitoring: One is the gate electrode surface; the other is the channel surface. This mini review introduced the new developments in chemical and biological detection of the two sensing interfaces. Specific focus was given on the modification technological approaches of the gate or channel surface. In particular, some unique strategies and surface designs aiming to facilitate signal-transduction and amplification were discussed. Several perspectives and current challenges of OECTs development were also briefly summarized.

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“…Later, Tao et al [77] reported a similar DNA sensor using complementary DNA (cDNA) as a probe and a nanoporous Au gate. A peptide nucleic acid (PNA) probe was used and adapted for DNA sensing due to its higher sensitivity and specificity.…”

Section: B Nucleotide Sensorsmentioning

confidence: 99%

Organic Electrochemical Transistors as an Emerging Platform for Bio-Sensing Applications: A Review

et al. 2021

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Organic electrochemical transistors (OECTs) have been recognized as a major emerging technology in the area of flexible electronics in the last decade. Although they have yet to be incorporated in common electronic fabrication technologies, they have considerably advanced as an emerging platform for biosensing applications. The paper provides a comprehensive and critical review of the most important advances in the field of OECT-based biosensors. A brief description of the device physics is given with the most important equations and a comparison has been made with the conventional MOSFET devices and characteristic equations. The use of OECTs as an emerging biosensing platform has been explored and their application as biomolecule, enzyme, bacteria, viruses, cells, nucleotide detectors as well as electrophysiological and wearable sensors has been reported. Furthermore, trends have been extracted and described in the paper in terms of fabrication technologies, electrode materials and most importantly, the semiconducting polymer. Additionally, future perspectives on the development and fabrication technologies of these devices have been further explored.

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A sensitive DNA sensor based on an organic electrochemical transistor using a peptide nucleic acid-modified nanoporous gold gate electrode

Abstract: An organic electrochemical transistor (OECT) based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate with porous anodic aluminum oxide (AAO) as a gate electrode was proposed for DNA sensing.

Cited by 30 publications

References 33 publications

Self-Healable Organic Electrochemical Transistor with High Transconductance, Fast Response, and Long-Term Stability

Self-Healable Organic Electrochemical Transistor with High Transconductance, Fast Response, and Long-Term Stability

Functional Sensing Interfaces of PEDOT:PSS Organic Electrochemical Transistors for Chemical and Biological Sensors: A Mini Review

Organic Electrochemical Transistors as an Emerging Platform for Bio-Sensing Applications: A Review

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