A sensitive Cu(salophen) modified screen-printed electrode for simultaneous determination of dopamine and uric acid

Abstract

T
 This research applied a nanostructured electrochemical sensor with a screen-printed electrode (SPE) for examining the dopamine (DA) electrocatalytic oxidation when uric acid (UA) was present. Cu(salophen) nanostructured modified SPE Cu(salophen)/SPE was employed to investigate the electrochemical behavior of DA. At optimal pH (pH 7.0), oxidation of DA at the modified electrode takes place at a potential around 100 mV less positive than at the unmodified SPE. Chronoamperometry was used to determine the diffusion coefficient of DA (D = 1.96×10-5 cm2 s-1). Differential pulse voltammetry (DPV) showed linear response in the range between 0.2-450.0 μM for DA. The limit of detection (LOD) of DA was computed to be 0.05 μM. Moreover, Cu(salophen)/SPE was employed for determining DA in the presence of UA using DPV. The DPV results showed that at the modified electrode, two well-separated oxidation peaks of DA and UA could be obtained at potentials of 180 and 325 mV, respectively. This separation forms the basis for the co-detection of these two materials on the surface of Cu(salophen)/SPE. This sensor was then employed to determine DA and UA in real specimens.

Simultaneous Determination of Doxorubicin and Dasatinib by using Screen-Printed Electrode/Ni–Fe Layered Double Hydroxide

“…Electrochemical approaches have spurred extensive interest in the area of sensing systems owing to ease of use, shorter analysis time, cost effectiveness, admirable sensitivity, accuracy, appreciable selectivity, miniaturization, and in situ applicability. − …”

Selective non-enzymatic uric acid sensing in the presence of dopamine: electropolymerized poly-pyrrole modified with a reduced graphene oxide/PEDOT:PSS composite

“…[40][41][42] Previously, several important studies have addressed the development of the simultaneous detection of uric acid and dopamine using modified electrodes. [43][44][45][46][47] Nevertheless, to the best of our knowledge, there is still a real need for the development of a selective uric acid sensor in the presence of dopamine. A new development is demonstrated here based on an imprinted polymer on the ErGO/PEDOT:PSS modified electrode.…”

A WSe2@Poly(3,4-ethylenedioxythiophene) nanocomposite based-electrochemical sensor for simultaneous detection of dopamine and uric acid

“…Therefore, early analyses of these molecules are highly important to deal with the concerned conditions. Recently, electrochemical methods have become attractive for the determination of DA and UA [5,6]. However, these two electroactive molecules have close oxidation potentials, which limits their selective detection in biological samples on traditional electrodes.…”