2008
DOI: 10.1016/j.jchromb.2008.01.054
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A sensitive and selective liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of novel trioxane antimalarials in different biomatrices using sample-pooling approach for high throughput pharmacokinetic studies☆

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Cited by 13 publications
(8 citation statements)
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References 22 publications
(18 reference statements)
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“…However, some authors only investigated the absolute matrix effect and did not evaluate the effect of matrices from different sources [31,[58][59][60][61][62][63][64][65][66][67][68]. Cao et al [62] have quantified methyl protodioscin, a natural furostanol saponin with antitumor activity, in rat plasma after PPT.…”
Section: Literature Overviewmentioning
confidence: 99%
“…However, some authors only investigated the absolute matrix effect and did not evaluate the effect of matrices from different sources [31,[58][59][60][61][62][63][64][65][66][67][68]. Cao et al [62] have quantified methyl protodioscin, a natural furostanol saponin with antitumor activity, in rat plasma after PPT.…”
Section: Literature Overviewmentioning
confidence: 99%
“…The assay method was adapted from a previously published work, where Singh, Sabarinath, Singh, and Gupta () developed and validated a method for quantification of 99/411 in plasma (rat, rabbit and monkey). Mass spectrometric detection was performed on an API 4000 mass spectrometer (Applied Biosystems, MDS Sciex Toronto, Canada) equipped with an electrospray ionization source and Perkin‐Elmer LC system (Perkin Elmer, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Selectivity,sensitivity,linearity,a ccuracy,precision werem easured and used ast he parameters tovalidate and assess the bioanalyticalassayperformance [12,13]. The most abundantion in the production spectraof ammoniumadductof parentdrug9 7-78( m/z =518.4), 97-63 and IS ass howni nTable 1.…”
Section: Methods Validationmentioning
confidence: 99%