A sensitive and selective LC–MS–MS method for simultaneous determination of picroside-I and kutkoside (active principles of herbal preparation picroliv) using solid phase extraction in rabbit plasma: Application to pharmacokinetic study

Effect of altitude on picroside content in core collections of Picrorhiza kurrooa from the north western Himalayas

“…The picroside I and picroside II content in P. kurrooa has been quantified by various methods, viz., HPLC, HPLC based on ultrasonic extraction and evaporative light scattering detection (ELSD), and HPTLC [13][14][15][16], whereas picroside I in plasma has been detected using HPLC and LC-MS-MS [17,18].…”

Simultaneous estimation of mangiferin and four secoiridoid glycosides in rat plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study of herbal preparation

“…Liquid chromatography coupled with tandem mass spectrometry was also used for analysis of free mangiferin in rat blood using microbore LC-MS/MS, providing LOQ with ∼0.05 g/ml and recovery ranging from ∼37.7 to 39.8% [13]. Vipul et al developed an LC-MS/MSbased bioanalytical method for determination of two iridoid glycoside (picroside-I and kutkoside) in rabbit plasma, where amarogentin was used as internal standard (IS) and this method required lengthy sample clean up step using solid phase extraction [14]. To our knowledge, no prior reports have described a sensitive LC-MS/MS-based method for determining these xanthoneand secoiridoid glycosides from plasma.…”

High-performance liquid chromatographic determination of acetyl-11-keto-α-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection: Application in pharmacokinetic studies

“…Apart from pharmacological studies aiming at molecular mechanisms such as their antitumor efficacy [3,9], it is necessary to analyze the plasma levels of these compounds to gain insight into their pharmacokinetic parameters. So far, most studies dealing with pharmacokinetics used mammalian animal models or human clinical studies [10,11]. The analytical methods usually combine solid phase or liquid-liquid plasma extraction with HPLC-UV or GC-MS detection [12,13].…”