2019
DOI: 10.1002/dvdy.131
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A sense of place, many times over ‐ pattern formation and evolution of repetitive morphological structures

Abstract: Fifty years ago, Lewis Wolpert introduced the concept of “positional information” to explain how patterns form in a multicellular embryonic field. Using morphogen gradients, whose continuous distributions of positional values are discretized via thresholds into distinct cellular states, he provided, at the theoretical level, an elegant solution to the “French Flag problem.” In the intervening years, many experimental studies have lent support to Wolpert's ideas. However, the embryonic patterning of highly repe… Show more

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Cited by 6 publications
(5 citation statements)
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References 153 publications
(405 reference statements)
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“…To understand the molecular basis of morphological evolution, as driven by changes in embryonic and postembryonic development, both cell-extrinsic and -intrinsic alterations need to be considered. 28 Here, we present an integrative approach to perform comparative gene coexpression analyses at the single-cell level. We demonstrate its functionality by testing single-cell transcriptomic data from the developing mouse limb for the occurrence of cell type-specific gene co-expression modules and assess their conservation and developmental dynamics in the corresponding cell populations of the chicken.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…To understand the molecular basis of morphological evolution, as driven by changes in embryonic and postembryonic development, both cell-extrinsic and -intrinsic alterations need to be considered. 28 Here, we present an integrative approach to perform comparative gene coexpression analyses at the single-cell level. We demonstrate its functionality by testing single-cell transcriptomic data from the developing mouse limb for the occurrence of cell type-specific gene co-expression modules and assess their conservation and developmental dynamics in the corresponding cell populations of the chicken.…”
Section: Discussionmentioning
confidence: 99%
“…To understand the molecular basis of morphological evolution, as driven by changes in embryonic and post‐embryonic development, both cell‐extrinsic and ‐intrinsic alterations need to be considered 28 . Here, we present an integrative approach to perform comparative gene co‐expression analyses at the single‐cell level.…”
Section: Discussionmentioning
confidence: 99%
“…To understand the molecular basis of morphological evolution, as driven by changes in embryonic and post-embryonic development, both cell-extrinsic and – intrinsic alterations need to be considered. 32 Here, we present an integrative approach to perform comparative gene co-expression analyses at the single-cell level. We demonstrate its functionality by testing single-cell transcriptomic data from the developing mouse limb for the occurrence of cell type-specific gene co-expression modules and assess their conservation and developmental dynamics in the corresponding cell populations of the chicken.…”
Section: Discussionmentioning
confidence: 99%
“…Since interphalangeal joint number varies widely across tetrapods -ranging from 1 in the human thumb, to over 15 in certain species of whale -it suggests that the locations of these early stripes of expression are not set individually, but rather are the result of an inherently iterative developmental mechanism that places joints at regular spatial intervals along the digit. Previous studies have proposed that a Turing-like mechanism might be responsible for the development of these patterns (12)(13)(14). In this scenario, a network of interacting and diffusing biochemical signals forms a reaction-diffusion system that selforganizes into a periodic pattern (15).…”
Section: Introductionmentioning
confidence: 99%
“…Finally, congenital defects in human digit patterning are frequently associated with mutations in members of the BMP pathway, including GDF5, BMPR1B , and Noggin ( NOG ), an extracellular BMP inhibitor known to bind GDF5 (26). Based on these observations, it has been hypothesized that regulatory interactions amongst diffusible members of the BMP pathway may play a critical role in generating the periodic phalanx-joint patterns characteristic of tetrapod digits (11, 13).…”
Section: Introductionmentioning
confidence: 99%