A senescence up-regulated protein: the rat thyroxine-binding globulin (TBG)

Savu, Lia; Vranckx, Roger; Rouaze-Romet, M; Maya, Michelle; Ea, Nunez; Tréton, Jacques; Il, Flink

doi:10.1016/0925-4439(91)90017-4

Cited by 33 publications

(15 citation statements)

References 20 publications

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“…Serum concentrations of TT 4 , FT 4 , TT 3 , and FT 3 changed significantly during aging, in accord with other studies (11,20,38). These changes lead to a higher FT 3 /FT 4 ratio in 24-mo-old rats that could be related to the much more marked decrease in FT 4 levels (79% vs. 6-mo-old rats), possibly due to a higher expression of TBG, as reported by Savu et al (42). Normally, decreased TH serum levels should stimulate TSH secretion and result in increased TSH serum levels.…”

Section: Discussionsupporting

confidence: 90%

Age-related changes in renal and hepatic cellular mechanisms associated with variations in rat serum thyroid hormone levels

Silvestri

Lombardi²,

Lange³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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Aging is associated with changes in thyroid gland physiology. Age-related changes in the contribution of peripheral tissues to thyroid hormone serum levels have yet to be systematically assessed. Here, we investigated age-related alterations in the contributions of the liver and kidney to thyroid hormone homeostasis using 6-, 12-, and 24-mo-old male Wistar rats. A significant and progressive decline in plasma thyroxine occurred with age, but triiodothyronine (T(3)) was decreased only at 24 mo. This was associated with an unchanged protein level of the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) in the kidney and with a decreased MCT8 level in the liver at 24 mo. Hepatic type I deiodinase (D1) protein level and activity declined progressively with age. Renal D1 levels were decreased at both 12 and 24 mo but D1 activity was decreased only at 24 mo. In the liver, no changes occurred in thyroid hormone receptor (TR) TRalpha(1), whereas a progressive increase in TRbeta(1) occurred at both mRNA and total protein levels. In the kidney, both TRalpha(1) and TRbeta(1) mRNA and total protein levels were unchanged between 6 and 12 mo but increased at 24 mo. Interestingly, nuclear TRbeta1 levels were decreased in both liver and kidney at 12 and 24 mo, whereas nuclear TRalpha(1) levels were unchanged. Collectively, our data show differential age-related changes among hepatic and renal MCT8 and D1 and TR expressions, and they suggest that renal D1 activity is maintained with age to compensate for the decrease in hepatic T(3) production.

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Section: Discussionsupporting

confidence: 90%

Age-related changes in renal and hepatic cellular mechanisms associated with variations in rat serum thyroid hormone levels

Silvestri

Lombardi²,

Lange³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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“…A more expressed response of pituitary thyroid axis to CR in younger rats, as well as stronger correlations between feed intakes and hormone concentrations, may indicate age-associated changes in the adaptation to caloric restriction. The age-related declines in T3 and T4 free fractions may result from an increase in thyroid hormone binding globulin expression observed during aging, as shown by Savu et al (1991). The effect of CR on thyroid hormones could be strain-dependent, since, unlike in our study conducted in male Sprague Dawley rats, a decline in total T4 was observed in 12-month-old Wistar rats as compared with their 6-month-old counterparts (Silvestri et al, 2008).…”

Section: Discussioncontrasting

confidence: 52%

The effects of caloric restriction and age on thyroid hormone signalling in the heart of rats

Lachowicz¹,

Fürstenberg²,

Pałkowska³

et al. 2014

J. Anim. Feed Sci.

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“…In rats and mice, TBG is synthesised by the liver prior to the development of fur and homeothermy, and not in adulthood until senescence (36,49,50). This is a similar pattern for TBG synthesis by M.eugenii and hepatic TTR synthesis by S.crassicaudata during development.…”

Section: Discussionsupporting

confidence: 50%

Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish

Richardson¹,

Monk²,

Shepherdley³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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Thyroid hormones are essential for vertebrate development. There is a characteristic rise in thyroid hormone levels in blood during critical periods of thyroid hormone-regulated development. Thyroid hormones are lipophilic compounds, which readily partition from an aqueous environment into a lipid environment. Thyroid hormone distributor proteins are required to ensure adequate distribution of thyroid hormones, throughout the aqueous environment of the blood, and to counteract the avid partitioning of thyroid hormones into the lipid environment of cell membranes. In human blood, these proteins are albumin, transthyretin and thyroxine-binding globulin. We analyzed the developmental profile of thyroid hormone distributor proteins in serum from a representative of each order of marsupials ( M. eugenii; S.crassicaudata), a reptile ( C. porosus), in two species of salmonoid fishes ( S. salar; O. tshawytsch), and throughout a calendar year for sea bream ( S. aurata). We demonstrated that during development, these animals have a thyroid hormone distributor protein present in their blood which is not present in the adult blood. At least in mammals, this additional protein has higher affinity for thyroid hormones than the thyroid hormone distributor proteins in the blood of the adult. In fish, reptile and polyprotodont marsupial, this protein was transthyretin. In a diprotodont marsupial, it was thyroxine-binding globulin. We propose an hypothesis that an augmented thyroid hormone distributor protein network contributes to the rise in total thyroid hormone levels in the blood during development.

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A senescence up-regulated protein: the rat thyroxine-binding globulin (TBG)

Cited by 33 publications

References 20 publications

Age-related changes in renal and hepatic cellular mechanisms associated with variations in rat serum thyroid hormone levels

Age-related changes in renal and hepatic cellular mechanisms associated with variations in rat serum thyroid hormone levels

The effects of caloric restriction and age on thyroid hormone signalling in the heart of rats

Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish

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