A Semi – Three Dimensional (3D) Bioprinted Neurocardiac System for Tissue Engineering of a Cardiac Autonomic Nervous System (CANS) Model
Ivana Hernandez,
Salma P. Ramirez,
Wendy V. Salazar
et al.
Abstract:In this study, we designed a functional neuro-cardiac model to help us examine the role of neuronal regulation and confirm the importance of neural innervation techniques for cardiac tissue regeneration. A three-dimensional (3D) bioprinted neuro-cardiac scaffold composed of a mixture of gelatin-alginate and alginate-genipin-fibrin hydrogels was developed with a 2:1 ratio of AC16 cardiomyocytes (CMs) and retinoic acid differentiated SH-SY5Y neuronal cells (NCs) respectively. A unique semi-3D bioprinting approac… Show more
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