A self-powered controllable microneedle drug delivery system for rapid blood pressure reduction

Chen, Zhongrong; Lai, Yulin; Xu, Siyu; Zhu, Mengfei; Sun, Yue; Cheng, Yue; Zhao, Gang

doi:10.1016/j.nanoen.2024.109344

Cited by 5 publications

(2 citation statements)

References 67 publications

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“…Second, some MN patches are self-powered and can generate microcurrents by harvesting mechanical energy or other external stimuli. 95 These microcurrents provide bioelectric stimulation to the tissues around the wound, promoting cell proliferation and repair. When combined with TENG technology, the selfpowered efficiency of the patches can be further improved, enhancing the effect of bioelectric stimulation and accelerating the wound healing process.…”

Section: Secondary Structuresmentioning

confidence: 99%

“…In the field of wound healing, MNs have great potential to offer new solutions for the treatment of hard-to-heal wounds, such as those caused by diabetes. − MN patches are typically encapsulated with bioactive substances, such as glucose oxidase , and hyaluronic acid, , which enable localized drug release and enhance therapeutic effects. Second, some MN patches are self-powered and can generate microcurrents by harvesting mechanical energy or other external stimuli . These microcurrents provide bioelectric stimulation to the tissues around the wound, promoting cell proliferation and repair.…”

Section: Multilevel Structures Of Tengsmentioning

confidence: 99%

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Silk Fibroin-Based Triboelectric Nanogenerators for Energy Harvesting and Biomedical Applications

Gan,

Wei,

Zhou

et al. 2024

ACS Appl. Nano Mater.

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Triboelectric nanogenerators (TENGs) developed from eco-friendly natural materials rather than traditional electronic materials are more favorable for biocompatible applications and for use in sustainable life-cycle analysis. Silk fibroin (SF) has emerged as an abundant natural biomaterial that shows great potential in the preparation of TENGs. Silk-based triboelectric nanogenerators (SF-TENGs) have green energy harvesting properties, are environmentally friendly, are biocompatible, are not fully present in conventional TENGs, and are important for the next generation of selfpowered electronic devices. In this review, the latest progress in SF-TENGs, including their applied materials, structural properties, manufacturing processes, and application scenarios, is discussed. These SF-TENGs show great potential for use in emerging energy and electronic applications as well as smart living and medical assistance. In addition, the potential value of SF-TENGs has been further explored, and the possibility and main challenges of expanding and applying SF-TENGs to the field of microneedles (MNs) are discussed.

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Section: Secondary Structuresmentioning

confidence: 99%

Section: Multilevel Structures Of Tengsmentioning

confidence: 99%

Silk Fibroin-Based Triboelectric Nanogenerators for Energy Harvesting and Biomedical Applications

Gan,

Wei,

Zhou

et al. 2024

ACS Appl. Nano Mater.

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ADSCC‐CM‐Induced Keratin Hydrogel‐Based Bioactive Microneedle Patch Containing Triamcinolone Acetonide for the Treatment of Pathological Scar

Li,

Yi,

et al. 2024

Adv Funct Materials

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Pathological scars (PS) are involved in the excessive response of inflammation and overactivation of myofibroblasts. Herein, a novel microneedle (MN) patch based on the adipose‐derived stem cell concentrated conditioned medium (ADSCC‐CM) cross‐linked keratin hydrogel is developed to load triamcinolone acetonide (TA), thereby achieving the dual‐drug delivery of ADSCC‐CM and TA to simultaneously reduce the inflammation and guide myofibroblast behaviors. Results not only confirm the ability of ADSCC‐CM to drive the formation of keratin‐based hydrogel, but also verify the dual‐drug release capacities of the hydrogel‐developed MNs (TA@AC‐MN). Using human hyperplastic scar fibroblast (HSF), the combination of ADSCC‐CM and TA demonstrates a pronounced synergistic effect in mitigating the detrimental effects of the inflammatory microenvironment on HSFs, including suppressing the production of reactive oxygen species and attenuating the expression of inflammatory factors. Compared with the clinically used TA, TA@AC‐MN promotes scar biomimetic repair (i.e., optimizing the proportion of collagen and increasing the tissue tensile strength). This study demonstrates that TA@AC‐MN has the capacity to provide a self‐managing and minimally invasive therapeutic strategy for PS.

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A Targeted and Responsive Nanoprodrug Delivery System for Synergistic Glioma Chemotherapy

Zhuo,

Wang,

Zhou

et al. 2024

Small

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Doxorubicin (DOX) is widely used as a chemotherapeutic agent for both hematologic and solid tumors and is a reasonable candidate for glioma treatment. However, its effectiveness is hindered by significant toxicity and drug resistance. Moreover, the presence of the blood–brain barrier (BBB) brings a crucial challenge to glioma therapy. In response, a GSH‐responsive and actively targeted nanoprodrug delivery system (cRGD/PSDOX‐Cur@NPs) are developed. In this system, a disulfide bond‐bridged DOX prodrug (PEG‐SS‐DOX) is designed to release specifically in the high glutathione (GSH) tumor environment, markedly reducing the cardiotoxicity associated with DOX. To further address DOX resistance, curcumin, serving as a P‐glycoprotein (P‐gp) inhibitor, effectively increased cellular DOX concentration. Consequently, cRGD/PSDOX‐Cur@NPs exhibited synergistic anti‐tumor effects in vitro. Furthermore, in vivo experiments validated the superior BBB penetration and brain‐targeting abilities of cRGD/PSDOX‐Cur@NPs, showcasing the remarkable potential for treating both subcutaneous and orthotopic gliomas. This research underscores that this nanoprodrug delivery system presents a novel approach to inhibiting glioma while addressing resistance and systemic toxicity.

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A self-powered controllable microneedle drug delivery system for rapid blood pressure reduction

Cited by 5 publications

References 67 publications

Silk Fibroin-Based Triboelectric Nanogenerators for Energy Harvesting and Biomedical Applications

Silk Fibroin-Based Triboelectric Nanogenerators for Energy Harvesting and Biomedical Applications

ADSCC‐CM‐Induced Keratin Hydrogel‐Based Bioactive Microneedle Patch Containing Triamcinolone Acetonide for the Treatment of Pathological Scar

A Targeted and Responsive Nanoprodrug Delivery System for Synergistic Glioma Chemotherapy

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