A self-illuminating nanoparticle for inflammation imaging and cancer therapy

Xu, Xiaoqiu; An, Huijie; Zhang, Dinglin; Tao, Hui; Li, Xiaohui; Huang, Jun; Zhang, Jianxiang

doi:10.1126/sciadv.aat2953

Cited by 158 publications

(123 citation statements)

References 69 publications

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“…Finally, florescence intensity was analyzed by Image J to calculate the concentration of L897 NPs. To analyze the blood t 1/2 , we imported the blood concentration values of L897 NPs at each time point into a pharmacokinetic software named Drug And Statistics, which was used according to the previous study …”

Section: Methodsmentioning

confidence: 99%

Molecular Engineering of an Organic NIR‐II Fluorophore with Aggregation‐Induced Emission Characteristics for In Vivo Imaging

Yang

et al. 2019

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101

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Design and synthesis of new fluorophores with emission in the second near‐infrared window (NIR‐II, 1000–1700 nm) have fueled the advancement of in vivo fluorescence imaging. Organic NIR‐II probes particularly attract tremendous attention due to excellent stability and biocompatibility, which facilitate clinical translation. However, reported organic NIR‐II fluorescent agents often suffer from low quantum yield and complicated design. In this study, the acceptor unit of a known NIR‐I aggregation‐induced emission (AIE) luminogen (AIEgen) is molecularly engineered by varying a single atom from sulfur to selenium, leading to redshifted absorption and emission spectra. After formulation of the newly prepared AIEgen, the resultant AIE nanoparticles (referred as L897 NPs) have an emission tail extending to 1200 nm with a high quantum yield of 5.8%. Based on the L897 NPs, noninvasive vessel imaging and lymphatic imaging are achieved with high signal‐to‐background ratio and deep penetration. Furthermore, the L897 NPs can be used as good contrast agents for tumor imaging and image‐guided surgery due to the high tumor/normal tissue ratio, which peaks at 9.0 ± 0.6. This work suggests a simple strategy for designing and manufacturing NIR‐II AIEgens and demonstrates the potential of NIR‐II AIEgens in vessel, lymphatic, and tumor imaging.

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Section: Methodsmentioning

confidence: 99%

Molecular Engineering of an Organic NIR‐II Fluorophore with Aggregation‐Induced Emission Characteristics for In Vivo Imaging

Yang

et al. 2019

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101

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“…BRET is a special case of resonance energy transfer, where the donor is a luciferase/luciferin system. As BRET acceptors, fluorescent materials such as FPs, 14,84,85 organic dyes, 35,[86][87][88][89][90][91] and QDs have been employed (Fig. 5a-c).…”

Section: Bret Systemsmentioning

confidence: 99%

Near-infrared fluorescent protein and bioluminescence-based probes for high-resolution in vivo optical imaging

Tiwari

2020

Mater. Adv.

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“…Luminol has also been incorporated within nanoparticles for CL imaging. Xu et al (2019) recently developed a self-illuminating nanoparticle using an amphiphilic Ce6-luminol-polyethylene glycol (CLP) polymer. The Ce6 (chlorin e6), a photosensitizer, can be excited by the BL from luminol in the presence of excess ROS and myeloperoxidase.…”

Section: Luminolmentioning

confidence: 99%

“…The Ce6 (chlorin e6), a photosensitizer, can be excited by the BL from luminol in the presence of excess ROS and myeloperoxidase. This excitation leads to generation of fluorescence and 1 O 2 by the Ce6 via bioluminescence resonance energy transfer (BRET), and can be used for detecting inflammation and for tumor photodynamic therapy (PDT) (Xu et al, 2019).…”

Section: Luminolmentioning

confidence: 99%

Ultrasound-Enhanced Chemiluminescence for Bioimaging

Dhamecha

Gonsalves

et al. 2020

Front. Bioeng. Biotechnol.

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Tissue imaging has emerged as an important aspect of theragnosis. It is essential not only to evaluate the degree of the disease and thus provide appropriate treatments, but also to monitor the delivery of administered drugs and the subsequent recovery of target tissues. Several techniques including magnetic resonance imaging (MRI), computational tomography (CT), acoustic tomography (AT), biofluorescence (BF) and chemiluminescence (CL), have been developed to reconstruct three-dimensional images of tissues. While imaging has been achieved with adequate spatial resolution for shallow depths, challenges still remain for imaging deep tissues. Energy loss is usually observed when using a magnetic field or traditional ultrasound (US), which leads to a need for more powerful energy input. This may subsequently result in tissue damage. CT requires exposure to radiation and a high dose of contrast agent to be administered for imaging. The BF technique, meanwhile, is affected by strong scattering of light and autofluorescence of tissues. The CL is a more selective and sensitive method as stable luminophores are produced from physiochemical reactions, e.g. with reactive oxygen species. Development of near infrared-emitting luminophores also bring potential for application of CL in deep tissues and whole animal studies. However, traditional CL imaging requires an enhancer to increase the intensity of low-level light emissions, while reducing the scattering of emitted light through turbid tissue environment. There has been interest in the use of focused ultrasound (FUS), which can allow acoustic waves to propagate within tissues and modulate chemiluminescence signals. While light scattering is decreased, the spatial resolution is increased with the assistance of US. In this review, chemiluminescence detection in deep tissues with assistance of FUS will be highlighted to discuss its potential in deep tissue imaging.

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A self-illuminating nanoparticle for inflammation imaging and cancer therapy

Abstract: A self-illuminating nanoparticle can function as an effective nanomedicine for inflammation imaging and cancer therapy.

Cited by 158 publications

References 69 publications

Molecular Engineering of an Organic NIR‐II Fluorophore with Aggregation‐Induced Emission Characteristics for In Vivo Imaging

Molecular Engineering of an Organic NIR‐II Fluorophore with Aggregation‐Induced Emission Characteristics for In Vivo Imaging

Near-infrared fluorescent protein and bioluminescence-based probes for high-resolution in vivo optical imaging

Ultrasound-Enhanced Chemiluminescence for Bioimaging

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