A self-healing, antioxidative organoid-chip for cell sorting, capture and release-on-demand

Yuan, Renqiang; You, Dan; Wang, Jieran; Chen, Zaozao; Ge, Liqin

doi:10.1016/j.cej.2021.129182

Cited by 12 publications

(6 citation statements)

References 65 publications

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“…When TA was added into the AN layer, the obvious sharp peak of AN@TA/PEI film as the adhesive substrate of the CRPS patch at 1635 cm −1 appeared (Figure 2b), and represented the imine linkage ( ν C  N ). [ 17 ] In the XPS survey spectrum of AN@TA and AN@TA/PEI films, peaks corresponding to C 1s, N 1s, and O 1s were observed (Figure S5a,b, Supporting Information), the content of N element in the AN@TA/PEI film was higher than that of the AN@TA film. Figure S5c,d (Supporting Information) presented the curve fits of the C 1s, and N 1s spectra of the AN@TA/PEI film.…”

Section: Resultsmentioning

confidence: 99%

“…As proof‐of‐concept in Figure 4a, the molecular stitch PEI could be removable‐on‐demand, when the film was treated with amino acid, owing to the destroyed Schiff‐base system and the reactivated dynamic imine bonds triggered by amino acids at the film‐tissue interfaces. [ 29 ] According to our previous work, [ 17 ] we have illustrated that a large number of amino groups in amino acid could compete for the binding sites of aldehyde or ketone groups in the polymer chain to propel the formation of the new Schiff‐base linkage. Consequently, the high adhesive state to skin tissue would be switched to the nonadhesive one under wet conditions once amino acid was the substitute for PEI chains (Figure 4a).…”

Section: Resultsmentioning

confidence: 99%

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LBL Noninvasively Peelable Biointerfacial Adhesives for Cutaneo‐Inspired pH/Tactility Artificial Receptors

Yuan

Yang

et al. 2022

Adv Healthcare Materials

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Besides barrier functions, skin possesses multiple sentiences to external stimuli (e.g., temperature, force, and humidity) for human‐outside interaction. Thus, skincare should be taken very seriously, especially by patients with sensory disorders. However, currently available skin‐mimicking devices are always limited by so much insufficient response functions and nontunable interface behaviors so as not to realize precise health monitoring and self‐defense against injury. Herein, a bioinspired cutaneous receptor‐perceptual system (CRPS) patch is presented, integrating hybrid pH indicators and triboelectric nanogenerators into biointerface film‐adhesives that are fabricated through facile layer‐by‐layer (LBL) self‐assembly of amide and Schiff‐base linkages between alginate grafted with N‐hydroxysuccinimide ester (AN), tannic acid (TA), and polyethylenimine (PEI). This CRPS patch is adhered robustly to the soft‐curved skin surface without failure via “molecular suturing,” and amino acid enables its benign peel‐on‐demand from tissue interfaces. Postdamage self‐healing brings it without surgical reoperation, avoiding extra cost, pain, as well as infection risks. Significantly, CRPS patches as artificial chemo/mechanoreceptors can remotely visualize skin physiological status by pH‐induced chromism using smartphones and prevent skin contact injury by tactility‐driven self‐powered electrical signals. Overall, the LBL‐based strategy to create controllably biointerface‐adhesive CRPS patches will usher in a new era of the mobihealth care platform supporting smart diagnosis and self‐protection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

LBL Noninvasively Peelable Biointerfacial Adhesives for Cutaneo‐Inspired pH/Tactility Artificial Receptors

Yuan

Yang

et al. 2022

Adv Healthcare Materials

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“…In an effort to boost wound healing, recent studies have investigated emerging technologies such as microfluidic technology, which regulates the discharge of bioactive molecules or cells via electric field manipulation [182,183], and 4D printing technology, which preconditions polymer materials to assume a specific form upon exposure to certain stimuli [184]. The concept of 4D printing was introduced by Skylar Tibbits in 2014 as a technique capable of temporal adaptation or transition between structures [185].…”

Section: Four-dimensional (4d)mentioning

confidence: 99%

Analysis of bioprinting strategies for skin diseases and injuries through structural and temporal dynamics: historical perspectives, research hotspots, and emerging trends

Teng,

Wang,

Wang

et al. 2024

Biofabrication

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Objective:This study endeavors to investigate the progression, research focal points, and budding trends in the realm of skin bioprinting over the past decade from a structural and temporal dynamics standpoint.Methods:Scholarly articles on skin bioprinting were obtained from WoSCC. A series of bibliometric tools comprising R software, CiteSpace, HistCite, and an alluvial generator were employed to discern historical characteristics, evolution of active topics, and upcoming tendencies in the area of skin bioprinting.Findings:Over the past decade, there has been a consistent rise in research interest in skin bioprinting, accompanied by an extensive array of meaningful scientific collaborations. Concurrently, diverse dynamic topics have emerged during various periods, as substantiated by an aggregate of 22 disciplines, 74 keywords, and 187 references demonstrating citation bursts. Four burgeoning research subfields were discerned through keyword clustering - namely, #3 "in situ bioprinting", #6 "vascular", #7 "xanthan gum", and #8 "collagen hydrogels". The keyword alluvial map reveals that Module 1, including "transplantation" etc., has primarily dominated the research module over the previous decade, maintaining enduring relevance despite annual shifts in keyword focus. Additionally, we mapped out the top six key modules from 2023 being "silk fibroin nanofiber", "system", "ionic liquid", "mechanism", and "foot ulcer". Three recent research subdivisions were identified via timeline visualization of references, particularly Clusters #0 "wound healing", #4 "situ mineralization", and #5 "3D bioprinter".Conclusion:Insights derived from bibliometric analyses illustrate present conditions and trends in skin bioprinting research, potentially aiding researchers in pinpointing central themes and pioneering novel investigative approaches in this field.

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“…The versatile technique used to construct the antibiotic-loaded nanosheets is applicable to other drugs with appropriate solubility with that of membrane components. Based on the principle of bio-adhesion/anti-adhesion, Yuan et al [ 56 ] developed an organ-like biological coating chip with self-repair and antioxidant functions through LbL self-assembly, which was used for cell sorting, capture, and on-demand release. In this work, two coatings with opposite functions on enhancing cell adhesion coatings were fabricated.…”

Section: Biomaterials Imitating Bivalvesmentioning

confidence: 99%

Research Progress of Chitosan-Based Biomimetic Materials

Zhang

et al. 2021

Marine Drugs

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Chitosan is a linear polysaccharide produced by deacetylation of natural biopolymer chitin. Owing to its good biocompatibility and biodegradability, non-toxicity, and easy processing, it has been widely used in many fields. After billions of years of survival of the fittest, many organisms have already evolved a nearly perfect structure. This paper reviews the research status of biomimetic functional materials that use chitosan as a matrix material to mimic the biological characteristics of bivalves, biological cell matrices, desert beetles, and honeycomb structure of bees. In addition, the application of biomimetic materials in wound healing, hemostasis, drug delivery, and smart materials is briefly overviewed according to their characteristics of adhesion, hemostasis, release, and adsorption. It also discusses prospects for their application and provides a reference for further research and development.

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A self-healing, antioxidative organoid-chip for cell sorting, capture and release-on-demand

Cited by 12 publications

References 65 publications

LBL Noninvasively Peelable Biointerfacial Adhesives for Cutaneo‐Inspired pH/Tactility Artificial Receptors

LBL Noninvasively Peelable Biointerfacial Adhesives for Cutaneo‐Inspired pH/Tactility Artificial Receptors

Analysis of bioprinting strategies for skin diseases and injuries through structural and temporal dynamics: historical perspectives, research hotspots, and emerging trends

Research Progress of Chitosan-Based Biomimetic Materials

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