A self-healable metallohydrogel for drug encapsulations and drug release

Dutta, Mita; Banerjee, Shreya; Mandal, Mahitosh; Bhattacharjee, Manish

doi:10.1039/d3ra00930k

Cited by 2 publications

(2 citation statements)

References 56 publications

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Section: Introductionmentioning

confidence: 99%

“…LMWGs can encapsulate and release biologically active compounds such as drugs, proteins, or vitamins, making them valuable for controlled-release applications that can be utilized in biomedical applications such as drug delivery, tissue engineering, and regenerative medicine. LMWGs can accommodate different metal ions to form metallogels 23−27 that can be used for sensing applications, 28 bioinspired catalysis, 29,30 anticancer properties, 31 and molecular recognitions. 32,33 Interestingly, though there are several reports where chelating ligands are presented as siderophore mimics, 34−39 there are no such reports available where the system picks up iron(III) selectively from an aqueous solution with a mixture of different metal ions and self-separates from the system.…”

Section: Introductionmentioning

confidence: 99%

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A Siderophore Mimicking Gelation Component for Capturing and Self-Separation of Fe(III) from an Aqueous Solution of Mixture of Metal Ions

Munjal,

Kyarikwal,

Sarkar

et al. 2024

Inorg. Chem.

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The carbohydrazide-based gelation component N 2 ,N 4 ,N 6 -(1,3,5-triazine-2,4,6-triyl)tris(benzene-1,3,5-tricarbohydrazide) (CBTC) was synthesized and characterized using various spectroscopic tools. CBTC and trimesic acid (TMA) get selfassembled to form metallogel with Fe 3+ , specifically through various noncovalent interactions in a DMSO and H 2 O mixture. The self-assembly shows remarkable specificity toward Fe(III) among different transition metal salts. It is pertinent to point out that the binding specificity for Fe 3+ can also be found in nature in the form of siderophores, as they are mainly involved in scavenging iron selectively from the surroundings. DFT studies have been used to investigate the possible interaction between the different components of the iron metallogel. To determine the selectivity of CBTC for iron, CBTC, along with trimesic acid, is used to interact with other metal ions, including Fe(III) ions, in a single system. The gelation components CBTC and TMA selectively bind with iron(III), which leads to the formation of metallogel and gets separated as a discrete layer, leaving the other metal ions in the solution. Therefore, CBTC and TMA together show iron-scavenging properties. This selective scavenging property is explored through FE-SEM, XPS, PXRD, IR, and ICP-AES analysis. The FE-SEM analysis shows a flower-petal-like morphology for the Fe(III) metallogel. The resemblance in the CBTC-TMA-Fe metallogel and metallogel obtained from the mixture of different metal salts is established through FE-SEM images and XPS analysis. The release of iron from the metallogel is achieved with the help of ascorbic acid, which converts Fe 3+ to Fe 2+ . In biological systems, iron also gets released similarly from siderophores. This is the first report where the synthesized gelation component CBTC molecule is capable of scavenging out iron in the form of metallogel and self-separating from the aqueous mixture in the presence of various other metal ions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Siderophore Mimicking Gelation Component for Capturing and Self-Separation of Fe(III) from an Aqueous Solution of Mixture of Metal Ions

Munjal,

Kyarikwal,

Sarkar

et al. 2024

Inorg. Chem.

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Low‐molecular‐weight gels from amino acid and peptide derivatives for controlled release and delivery

Giuri,

Cenciarelli,

Tomasini

2024

Journal of Peptide Science

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Low‐molecular‐weight (LMW) gelators are a versatile class of compounds able to self‐assemble and to form supramolecular materials, such as gels. The use of LMW peptides to produce these gels shows many advantages, because of their wide structure tunability, the low‐cost and effective synthesis, and the in vivo biocompatibility and biodegradability, which makes them optimal candidates for release and delivery applications. In addition, in these materials, the binding of the hosts may occur through a variety of noncovalent interactions, which are also the main factors responsible for the self‐assembly of the gelators, and through specific interactions with the fibers or the pores of the gel matrix. This review aims to report LMW gels based on amino acid and peptide derivatives used for the release of many different species (drugs, fragrances, dyes, proteins, and cells) with a focus on the possible strategies to incorporate the cargo in these materials, and to demonstrate how versatile these self‐assembled materials are in several applications.

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A self-healable metallohydrogel for drug encapsulations and drug release

Abstract: A self-healable metallohydrogel of Mn(ii) has been prepared using a low molecular weight gelator, Na2HL, which is capable of encapsulation and delivery of the anti-cancer drug, gemcitabine and the NSAID, indomethacin.

Cited by 2 publications

References 56 publications

A Siderophore Mimicking Gelation Component for Capturing and Self-Separation of Fe(III) from an Aqueous Solution of Mixture of Metal Ions

A Siderophore Mimicking Gelation Component for Capturing and Self-Separation of Fe(III) from an Aqueous Solution of Mixture of Metal Ions

Low‐molecular‐weight gels from amino acid and peptide derivatives for controlled release and delivery

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