A self-filling micropump based on PCB technology

Wego, Ansgar; Pagel, Lienhard

doi:10.1016/s0924-4247(00)00519-7

Cited by 108 publications

(70 citation statements)

References 5 publications

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“…The success of electrophoresis in microchannels for genomics has been a spectacular example [65]. Investigators have capitalized on continuing innovations in microfabrication to develop individual microfluidic components such as valves and pumps as well as diverse microsensors that operate in microchannels or microwells [57,58,[66][67][68][69][70][71][72][73][74][75][76][77] and several microscale active and passive flow regulators have been described [78][79][80][81].…”

Section: Adaptation For Chronic Perfusionmentioning

confidence: 99%

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig

Chen

Kujawa

McKenna

et al. 2005

Journal of Controlled Release

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Rapid progress in understanding the molecular mechanisms associated with cochlear and auditory nerve degenerative processes offers hope for the development of gene-transfer and molecular approaches to treat these diseases in patients. For therapies based on these discoveries to become clinically useful, it will be necessary to develop safe and reliable mechanisms for the delivery of drugs into the inner ear, bypassing the blood-labyrinthine barrier. Toward the goal of developing an inner ear perfusion device for human use, a reciprocating microfluidic system that allows perfusion of drugs into the cochlear perilymph through a single inlet hole in scala tympani of the basal turn was developed. The performance of a prototype, extracorporeal reciprocating perfusion system in guinea pigs is described. Analysis of the cochlear distribution of compounds after perfusion took advantage of the place-dependent generation of responses to tones along the length of the cochlea. Perfusion with a control artificial perilymph solution had no effect. Two drugs with wellcharacterized effects on cochlear physiology, salicylate (5 mM) and DNQX (6,7-Dinitroquinoxaline-2,3-dione; 100 and 300 μM), reversibly altered responses. The magnitude of drug effect decreased with distance from the perfusion pipette for up to 10 mm, and increased with dose and length of application.

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Section: Adaptation For Chronic Perfusionmentioning

confidence: 99%

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig

Chen

Kujawa

McKenna

et al. 2005

Journal of Controlled Release

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“…As an example, we consider the design of a microfluidic pump for "lab-on-a-chip" (LOC) applications. A popular method for controlling the flow of fluids in LOC systems is based on deforming diaphragms driven by piezoelectric, 18,19 thermopneumatic, 20,21 electrostatic 22,23 , electromagnetic 24 , and shape memory actuation 25,26 . The advantage of this approach to micropump design is the independence of the fluid medium.…”

Section: Lab-on-a-chip Applicationmentioning

confidence: 99%

A Magnetocaloric Pump for Lab-On-Chip Technology: Phase I Report

Love¹

2004

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“…Currently, many attempts are underway to develop inexpensive, reliable, and miniaturized means for the precise control of small amounts of liquids in microcavities (Shoji et al, 1998;Elwenspoek et al, 1994;Wego and Pagel, 2001;Nguyen and Huang, 2001;Andersson et al, 2001;Unger et al, 2000). Electrokinetic¯uid handling is one particularly appealing method (Effenhauser, 1998 andKutter, 2000), since it requires no moving parts and allows for highly parallel system architectures.…”

Section: Introductionmentioning

confidence: 99%

“…Feasibility of pump sterilization. An impressive arsenal of pumps, based on silicon and polymer micromaching, has been described (Shoji, 1998;Elwenspoek et al, 1994;Wego and Pagel, 2001;Nguyean and Huang, 2001;Andersson et al, 2001). However, thorough investigation reveals that the constant delivery of small¯ow rates cannot be met by any of the pumps reported without signi®cant further development, in particular under the side condition of a very inexpensive pump manufacturing process enabling disposability.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2002

Biomedical Microdevices

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Abstract. An inexpensive and simple pumping principle is described that is capable of delivering both small and constant ow rates (10±1,000 nl/min) over a longer period of time (days to weeks). The concept is based on controlled evaporation of a liquid through a membrane into a gas space containing a sorption agent. As long as the sorption agent keeps the vapor pressure in the gas phase below saturation,¯uid evaporated from the membrane is replaced by capillary forces inducing¯ow from a reservoir. In a feasibility study, a total volume of 300 ml of Ringer's solution has been continuously pumped over a period of six days, resulting in an constant average¯ow rate of 35 nl/min (590 pl/s). The maximum liquid volume transported is limited by sorption capacity and amount of the sorption agent. Low fabrication costs, high reliability (no moving parts), the suitability for integration into planar system architectures and the lack of a special external energy source besides an environment of regulated temperature are important features of the concept, in particular with regard to its potential application in continuous patient monitoring. Truly continuous¯ow can be achieved in contrast to many other pump mechanisms leading to discontinuous, pulse-type¯ow. A challenge for a broader range of applications is the inherent temperature dependence of thē ow rate. In its current version, the pump can only be used in a suction-mode.

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A self-filling micropump based on PCB technology

Cited by 108 publications

References 5 publications

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig

Inner ear drug delivery via a reciprocating perfusion system in the guinea pig

A Magnetocaloric Pump for Lab-On-Chip Technology: Phase I Report

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