“…53 Twelve of the studies were designed to measure cognitive function as a primary endpoint. 28,30,31,34,39,40,43,45,46,50,51,53,54 Nine studies included objective measures of cognitive function, 31,36,37,39,40,46,47,51,53 twenty-one included subjective measures of cognitive function, 27–31,33,35–38,41–45,47–50,52–55 and four studies included both objective and subjective cognitive function measures. 36,37,47,53 Sample sizes ranged from as few as 4 (for the case series) to 658.…”