A self-defensive antibacterial coating acting through the bacteria-triggered release of a hydrophobic antibiotic from layer-by-layer films

Wang, Bailiang; Liu, Huihua; Wang, Zefeng; Shi, Shuai; Nan, Kaihui; Xu, Qingwen; Ye, Zi; Chen, Hao

doi:10.1039/c6tb02614a

Cited by 84 publications

(57 citation statements)

References 52 publications

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“…Such bacteria‐triggered antibiotic‐releasing coatings show great promise for easing the problems that traditional release‐killing coatings always suffer from, such as the rise of drug‐resistant bacteria, the undesired cytotoxicity effects, and the premature exhaustion of antibiotics induced by the sustained release or overuse of antibiotics. Since then, several groups have involved in developing such pH‐responsive antibiotic delivery coatings to treat bacterial infections . For example, an antibacterial and antioxidant coating was constructed on titanium (Ti) substrates via incorporation of polyelectrolyte multilayers composed of TA/gentamicin sulfate (GS) with chitosan–polycaprolactone nanofibers.…”

Section: Self‐defensive Antibacterial Coatingsmentioning

confidence: 99%

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Wei

Chen

2019

Adv Healthcare Materials

284

204

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Antibacterial coatings that eliminate initial bacterial attachment and prevent subsequent biofilm formation are essential in a number of applications, especially implanted medical devices. Although various approaches, including bacteria‐repelling and bacteria‐killing mechanisms, have been developed, none of them have been entirely successful due to their inherent drawbacks. In recent years, antibacterial coatings that are responsive to the bacterial microenvironment, that possess two or more killing mechanisms, or that have triggered‐cleaning capability have emerged as promising solutions for bacterial infection and contamination problems. This review focuses on recent progress on three types of such responsive and synergistic antibacterial coatings, including i) self‐defensive antibacterial coatings, which can “turn on” biocidal activity in response to a bacteria‐containing microenvironment; ii) synergistic antibacterial coatings, which possess two or more killing mechanisms that interact synergistically to reinforce each other; and iii) smart “kill‐and‐release” antibacterial coatings, which can switch functionality between bacteria killing and bacteria releasing under a proper stimulus. The design principles and potential applications of these coatings are discussed and a brief perspective on remaining challenges and future research directions is presented.

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Section: Self‐defensive Antibacterial Coatingsmentioning

confidence: 99%

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Wei

Chen

2019

Adv Healthcare Materials

284

204

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“…3.2. Characterization of (TA-GO/Lys) 4 Coating. Besides the component of the films, as is well known, the functionalities of proteins and protein multilayer coating were affected greatly by the conformation of protein.…”

Section: Resultsmentioning

confidence: 99%

“…However, the abuse of antibiotics can lead to a worse situation of resistance to the antibiotics. 4 The interactions of cells and/ or bacteria with materials take place primarily on the interface of implants, such that the fabricating multiple functional surfaces of the implanted dental material attracted particular interests and provided new opportunities for novel implants. 5,6 Integrating osteoinductive and antibacterial materials into the implants is a general way to fabricate implants bearing multiple functionalities.…”

Section: Introductionmentioning

confidence: 99%

Lysozyme (Lys), Tannic Acid (TA), and Graphene Oxide (GO) Thin Coating for Antibacterial and Enhanced Osteogenesis

Gao

Tang

et al. 2019

ACS Appl. Bio Mater.

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Dental implants have great potential in the global market, around $3.7 billion in 2015, which will increase to $7 billion in 2023 with an annual increase rate of 8.2%. Incorporating antibacterial and osteogenic agents into implants is helpful to make the dental implants successful, which can be endowed by coatings. In recent years, graphene oxide (GO) and its composite materials have shown advances in the biomedical field. Lysozyme (Lys) and tannic acid (TA) are naturally derived, with promising antibacterial and osteogenic properties as well. In the present study, the strong antibacterial and enhanced osteogenic multilayer coating is fabricated using the facile and controllable layer by layer (LBL) technique to integrate GO, Lys, and TA. The thickness of coating exhibited a continuous growth with the deposited process as proved from UV−vis and ellipsometry data, and the physical properties of the coating, such as wettability, roughness, and stiffness are well characterized. The coatings exhibited the synergic effect on the killing bacteria, both Gram-negative bacteria and Grampositive bacteria represented by E. coli and S. aureus, respectively, and enhancing osteogenesis of dental pulp stem cells (hDPSCs), showing the potential application on coatings of dental implants. Thus, the strategy applied here will inspire the design and development of dual functional surfaces for the success of implanted dental surface in future.

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“…Polyelectrolyte multilayers are also here a typical option for the release of one or several antimicrobials [102]. Also of interest is the novel generation of polymer scaffolds of "smart materials" able to initialize antimicrobial release when stimulated by changes in pH, ionic strength or temperature [105][106][107]. New approaches are also being explored in terms of the released compound.…”

Section: Releasable Antimicrobialsmentioning

confidence: 99%

Electroenhanced Antimicrobial Coating Based on Conjugated Polymers with Covalently Coupled Silver Nanoparticles Prevents Staphylococcus aureus Biofilm Formation

Gomez-Carretero

Nybom

Richter‐Dahlfors

2017

Adv Healthcare Materials

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The incidence of hospital-acquired infections is to a large extent due to device-associated infections. Bacterial attachment and biofilm formation on surfaces of medical devices often act as seeding points of infection. To prevent such infections, coatings based on silver nanoparticles (AgNPs) are often applied, however with varying clinical success. Here, the traditional AgNP-based antibacterial technology is reimagined, now forming the base for an electroenhanced antimicrobial coating. To integrate AgNPs in an electrically conducting polymer layer, a simple, yet effective chemical strategy based on poly(hydroxymethyl 3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT-MeOH:PSS) and (3-aminopropyl)triethoxysilane is designed. The resultant PEDOT-MeOH:PSS-AgNP composite presents a consistent coating of covalently linked AgNPs, as shown by scanning electron microscopy and surface plasmon resonance analysis. The efficacy of the coatings, with and without electrical addressing, is then tested against Staphylococcus aureus, a major colonizer of medical implants. Using custom-designed culturing devices, a nearly complete prevention of biofilm growth is obtained in AgNP composite devices addressed with a square wave voltage input. It is concluded that this electroenhancement of the bactericidal effect of the coupled AgNPs offers a novel, efficient solution against biofilm colonization of medical implants.

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A self-defensive antibacterial coating acting through the bacteria-triggered release of a hydrophobic antibiotic from layer-by-layer films

Abstract: Drug delivery systems play important roles in the construction of antibacterial coatings on the surfaces of biomaterials.

Cited by 84 publications

References 52 publications

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Responsive and Synergistic Antibacterial Coatings: Fighting against Bacteria in a Smart and Effective Way

Lysozyme (Lys), Tannic Acid (TA), and Graphene Oxide (GO) Thin Coating for Antibacterial and Enhanced Osteogenesis

Electroenhanced Antimicrobial Coating Based on Conjugated Polymers with Covalently Coupled Silver Nanoparticles Prevents Staphylococcus aureus Biofilm Formation

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