A self‐controlled study of intralesional injection of diprospan combined with topical timolol cream for treatment of thick superficial infantile hemangiomas

Abstract

Topical application of timolol cream is effective and convenient for treating superficial infantile hemangiomas. Intralesional injection of corticosteroids, such as diprospan, is useful for the treatment of superficia infantile hemangiomas without systemic side effects. We conducted a self-controlled study to investigate whether a combination of intralesional injection of diprospan with topical timolol 0.5% cream would be more efficient than timolol cream alone in thick superficial infantile hemangiomas. Thirty-eight patients with 39 thick superficial infantile hemangiomas were recruited. Each lesion was randomly divided into two equal parts: one part was treated with topical timolol 0.5% cream (timolol cream group), while the other part was treated with injection of diprospan combined with topical timolol 0.5% cream (combined treatment group). Infants were followed every 4 weeks to determine whether injections should be continued, and timolol cream was applied four times daily for 5 months. During 5 months of treatment, three specialist physicians were invited to evaluate the therapeutic effects. The combined treatment group showed better lesion involution than did the timolol cream group regarding lesion thickness and color of lesions. The combination of intralesional injection of diprospan with topical timolol 0.5% cream is a suitable and safe strategy for thick superficial infantile hemangiomas.

Preemptive Infiltration with Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE): study protocol for a randomized controlled trial

“…Due to its large particles occluding the blood vessels supplying the spinal cord, betamethasone was previously reported to result in infarction of spinal cord after epidural analgesia [20]. However, we speculate that local peri-incisional infiltration of betamethasone is safe, as betamethasone has previously been used for intralesional [21], local infiltration [22], intramuscular [23], and intraarticular injections [16]. Local infiltration of steroid hormones will undeniably present the risk of delayed wound healing or local infection.…”

Preemptive Infiltration with Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE): A Study Protocol

“…Due to its large particles occluding the blood vessels supplying the spinal cord, betamethasone was previously reported to result in infarction of spinal cord after epidural analgesia. 20 However, we speculate that local peri-incisional infiltration of betamethasone is safe as betamethasone has previously been used for intralesional, 21 local infiltration, 22 intramuscular, 23 and intraarticular injections. 16 Local infiltration of steroid hormones undeniably present the risk of delayed wound healing or local infection.…”

Systemic, local, and sclerotherapy drugs: What do we know about drug prescribing in vascular anomalies?

“…Figure 2 shows that the LOE was higher for efficacy than safety data. Among RCTs, the majority focused on efficacy ( n = 19) and the minority on safety ( n = 6) 7–22 …”