A self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury

Liu, Yang; Ye, Hui; Satkunendrarajah, Kajana; Yao, Gordon S; Bayon, Yves; Fehlings, Michael G.

doi:10.1016/j.actbio.2013.06.001

Cited by 97 publications

(91 citation statements)

References 43 publications

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“…QL6, one of these self-assembled nanomaterial peptides, preserves spinal cord tissue upon injection into rats 24 h after spinal cord injury. The mode of action of QL6 is suggested to be a significant reduction in apoptosis, inflammation, and astrogliosis [53].…”

Section: Wide Spectrum Of Immune Stimulatory Peptidesmentioning

confidence: 99%

Immunomodulatory effects of anti-microbial peptides

Ötvös¹

2016

Acta Microbiologica et Immunologica Hungarica

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Anti-microbial peptides (AMPs) were originally thought to exert protecting actions against bacterial infection by disintegrating bacterial membranes. Upon identification of internal bacterial targets, the view changed and moved toward inhibition of prokaryote-specific biochemical processes. However, the level of none of these activities can explain the robust efficacy of some of these peptides in animal models of systemic and cutaneous infections. A rapidly growing panel of reports suggests that AMPs, now called host-defense peptides (HDPs), act through activating the immune system of the host. This includes recruitment and activation of macrophages and mast cells, inducing chemokine production and altering NF-κB signaling processes. As a result, both pro-and anti-inflammatory responses are elevated together with activation of innate and adaptive immunity mechanisms, wound healing, and apoptosis. HDPs sterilize the systemic circulation and local injury sites significantly more efficiently than pure single-endpoint in vitro microbiological or biochemical data would suggest and actively aid recovering from tissue damage after or even without bacterial infections. However, the multiple and, often opposing, immunomodulatory functions of HDPs require exceptional care in therapeutic considerations.

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Section: Wide Spectrum Of Immune Stimulatory Peptidesmentioning

confidence: 99%

Immunomodulatory effects of anti-microbial peptides

Ötvös¹

2016

Acta Microbiologica et Immunologica Hungarica

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“…Liu et al used peptide QL6, which self-assembles into-sheets at neutral pH, as their therapeutic agent for SCI [15]. This study found a favorable distribution of the nano bers after injection and almost full degradation by eight weeks.…”

Section: Self-assembling Peptide Approachesmentioning

confidence: 93%

Nanomaterials for Spinal Cord Injury Recovery

Amezcua¹,

Vimbela²,

Stout³

2017

Spine Res

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Nanotechnology and nanomaterials have had a significant positive impact within the biomedical field for quite some time, and have included cardiovascular, cartilage, and neural tissue engineering applications. Due to its potential for treating neural tissue, current research is investigating the use of nanomaterials for spinal cord injury (SCI), an injury characterized by tissue damage and the disruption of communication between the brain to the body. To treat such an injury, cell-based therapy has shown promising results, and the following papers are recommended. This communication will focus on nanoparticle, carbon nanotubes, and self-assembling peptide approaches for treating SCI, as well as concerns of toxicity.

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“…Although QL6 nanofibers themselves might improve cell survival 4,15 , nevertheless, the use of growth factors seems to be advantageous 16,17,18,19,20,21 . They can be administered either by hydrogels releasing growth factors 22 , or by application via osmotic pumps (as described above).…”

Section: Discussionmentioning

confidence: 99%

“…In order to provide good tissue conditions for NPC survival and integration, several studies have chosen injection points in the adjacent white matter, 2 mm rostral or caudal to the lesion site and not directly in the epicenter of the lesion 4,15,18 . There, NPCs have a better chance for survival, integration, and differentiation into astrocytes, oligodendrocytes or neurons, and can migrate towards or into the lesion resulting in axonal sprouting and improved axonal connectivity.…”

Section: Discussionmentioning

confidence: 99%

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Zweckberger

Liu

Wang

et al. 2015

JoVE

Self Cite

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Spinal cord injuries (SCI) cause serious neurological impairment and psychological, economic, and social consequences for patients and their families. Clinically, more than 50% of SCI affect the cervical spine 1 . As a consequence of the primary injury, a cascade of secondary mechanisms including inflammation, apoptosis, and demyelination occur finally leading to tissue scarring and development of intramedullary cavities 2,3 . Both represent physical and chemical barriers to cell transplantation, integration, and regeneration. Therefore, shaping the inhibitory environment and bridging cavities to create a supportive milieu for cell transplantation and regeneration is a promising therapeutic target 4 . Here, a contusion/ compression model of cervical SCI using an aneurysm clip is described. This model is more clinically relevant than other experimental models, since complete transection or ruptures of the cord are rare. Also in comparison to the weight drop model, which in particular damage the dorsum columns, circumferential compression of the spinal cord appears advantageous. Clip closing force and duration can be adjusted to achieve different injury severity. A ring spring facilitates precise calibration and constancy of clip force. Under physiological conditions, synthetic selfassembling peptides (SAP) self-assemble into nanofibers and thus, are appealing for application in SCI 5 . They can be injected directly into the lesion minimizing damage to the cord. SAPs are biocompatible structures erecting scaffolds to bridge intramedullary cavities and thus, equip the damaged cord for regenerative treatments. K2(QL)6K2 (QL6) is a novel SAP introduced by Dong et al. 6 In comparison to other peptides, QL6self-assembles into β-sheets at neutral pH 6 .14 days after SCI, after the acute stage, SAPs are injected into the center of the lesion and neural precursor cells (NPC) are injected into adjacent dorsal columns. In order to support cell survival, transplantation is combined with continuous subdural administration of growth factors by osmotic micro pumps for 7 days. Video LinkThe video component of this article can be found at

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A self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury

Cited by 97 publications

References 43 publications

Immunomodulatory effects of anti-microbial peptides

Immunomodulatory effects of anti-microbial peptides

Nanomaterials for Spinal Cord Injury Recovery

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

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