A self-assembled polymeric micellar immunomodulator for cancer treatment based on cationic amphiphilic polymers

Yim, Hyeona; Park, Wooram; Kim, Dongin; Fahmy, Tarek M.; Na, Kun

doi:10.1016/j.biomaterials.2014.08.029

Cited by 41 publications

(31 citation statements)

References 39 publications

(29 reference statements)

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“…Taken together, HA‐based NPs can be utilized for diseases including various kinds of cancer, RA, and diabetes, as carriers for chemotherapy (CHT), photodynamic therapy, and photothermal therapy, along with carriers for biologics such as siRNA and applications in immunotherapy (IMT) ( Table 3 ). In the end, these examples demonstrate the diverse possibilities available by using HA‐based NPs as actively targeted carriers and/or triggered delivery systems in response to Hyal overexpression at localized sites of disease.…”

Section: Stimuli‐responsive Nanomaterials Based On Hyaluronic Acidmentioning

confidence: 96%

Hyaluronic Acid–Based Activatable Nanomaterials for Stimuli‐Responsive Imaging and Therapeutics: Beyond CD44‐Mediated Drug Delivery

et al. 2019

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There is a rapidly increasing interest in developing stimuli-responsive nanomaterials for treating a variety of diseases. By enabling the activation of function locally at the sites of interest, it is possible to increase therapeutic efficacy significantly while simultaneously reducing adverse side effects. While there are many sophisticated nanomaterials available, they are often highly complex and not easily transferrable to industrial scales and clinical settings. However, nanomaterials based on hyaluronic acid offer a compelling strategy for reducing their complexity while retaining several desirable benefits such as active targeting and stimuli-responsive degradation. Herein, the basic properties of hyaluronic acid, its binding partners, and natural routes for degradation by hyaluronidases-hyaluronic-aciddegrading enzymes-and oxidative stresses are discussed. Recent advances in designing hyaluronic acid-based, actively targeted, hyaluronidase-or reactive-oxygen-species-responsive nanomaterials for both diagnostic imaging and therapeutic delivery, which go beyond merely the classical targeting of CD44, are summarized.

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Section: Stimuli‐responsive Nanomaterials Based On Hyaluronic Acidmentioning

confidence: 96%

Hyaluronic Acid–Based Activatable Nanomaterials for Stimuli‐Responsive Imaging and Therapeutics: Beyond CD44‐Mediated Drug Delivery

et al. 2019

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“…Thus, it is called as a primary micelle by Eisenberg, [24] which is usually smaller than 20 nm. The complex micelles are more complicated in structure and larger in size (usually larger than 100 nm) [25]. From the result of this work, it was found that M-P-Se micelles formed the complex micelles in the aqueous solution.…”

Section: Response To Gshmentioning

confidence: 98%

Redox poly(ethylene glycol)-b-poly(l-lactide) micelles containing diselenide bonds for effective drug delivery

Zeng

Zhou

et al. 2015

J Mater Sci: Mater Med

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Bioreducible polymers have appeared as the ideal drug carriers for tumor therapy due to their properties of high stability in extracellular circulation and rapid drug release in intracellular reducing environment. Recently, the diselenide bond has emerged as a new reduction-sensitive linkage. In this work, the amphiphilic poly(ethylene glycol)-b-poly(L-lactide) containing diselenide bond has been synthesized and used to load anti-tumor drug, docetaxel (DTX), to form the redox micelles. It was found that the redox micelles showed a rapid response to glutataione (GSH), which resulted in a fast release of DTX in the presence of GSH. In contrast, <40 % of DTX was released from the micelles within 72 h under the normal condition (absence of GSH). The DTX-loaded redox micelles showed the significant inhibition effect to MCF-7 cells, and the cytotoxicity was dependent on the intracellular GSH concentrations. Moreover, considering the potentially clinical applications of the micelles through intravenous injection, the blood compatibility was also studied by the hemolysis analysis, activated partial thromboplastin time, prothrombin time and thromboelastography assays. These results confirmed that the redox micelles showed good blood safety, suggesting a potential application in tumor therapy.

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“…M2 macrophages can also present antigens, but they cannot realize the immune stimulation effect of T cells. [ 105 ] Hence, the macrophage‐based cancer immunotherapy is mainly divided into: 1) Enhancing the ability of macrophage antigen presentation; 2) Inducing TAM to transform to M1 macrophage. [ 106 ]…”

Section: Targeted and Tumor Environment Responsive Gene Delivery Intomentioning

confidence: 99%

Polymeric Nonviral Gene Delivery Systems for Cancer Immunotherapy

Cai

et al. 2020

Advanced Therapeutics

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Unlike viral vectors with their undesired safety or immunogenicity concerns, biocompatible polymeric nonviral vectors as gene delivery systems are more promising in gene or cell therapy. Evidence has demonstrated that the rational design of polymeric nonviral gene vectors with optimal structure, charge density, biocompatibility, and stimulus responsiveness can deliver therapeutic genes or gene vaccines (in terms of deoxyribonucleic acid DNA or ribonucleic acid RNA) into tumor‐associated immunocytes (i.e., macrophages, T cells, or dendritic cells) in an effective and controllable manner for enhanced cancer immunotherapy. However, a timely and systematic summary of this subject is lacking. This review presents an overview of polymeric nonviral carriers with immune cell transfection ability and their potential applications in cancer immunotherapy; it also provides a tutorial for designing polymeric immune‐cell genetic modification vector, although there are still few vectors in the product pipeline. With the rapid growth of immunotherapy in cancer treatment and knowledge accumulation in vector structure design, polymeric nonviral gene delivery systems may provide new hope for tumor therapy.

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A self-assembled polymeric micellar immunomodulator for cancer treatment based on cationic amphiphilic polymers

Cited by 41 publications

References 39 publications

Hyaluronic Acid–Based Activatable Nanomaterials for Stimuli‐Responsive Imaging and Therapeutics: Beyond CD44‐Mediated Drug Delivery

Hyaluronic Acid–Based Activatable Nanomaterials for Stimuli‐Responsive Imaging and Therapeutics: Beyond CD44‐Mediated Drug Delivery

Redox poly(ethylene glycol)-b-poly(l-lactide) micelles containing diselenide bonds for effective drug delivery

Polymeric Nonviral Gene Delivery Systems for Cancer Immunotherapy

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