A Selective-Tumor-Penetrating Strategy via Unidirectional Direct Transfer for Intravesical Therapy of Bladder Cancer
Xiaowen Qin,
Heng Wang,
Wentao Xu
et al.
Abstract:A selective tumor-penetrating strategy generally exploits
tumor-targeted
ligands to modify drugs so that the conjugate preferentially enters
tumors and subsequently undergoes transcellular transport to penetrate
tumors. However, this process shields ligands from their corresponding
targets on the cell surface, possibly inducing an off-target effect
during drug penetration at the tumor-normal interface. Herein, we
first describe a selective tumor-penetrating drug (R11-phalloidin
conjugates) for intravesical the… Show more
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