A selective sweep in a Varroa destructor resistant honeybee (Apis mellifera) population

Lattorff, H. Michael G.; Buchholz, Josephine; Fries, Ingemar; Moritz, Robin F. A.

doi:10.1016/j.meegid.2015.01.025

Cited by 25 publications

(31 citation statements)

References 50 publications

(51 reference statements)

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“…They found a strong overall loss of heterozygosity in these regions, suggesting that genetic drift, selection, or both had occurred in the population. On two loci on chromosome 7, the reduction was greater than what could be expected from genetic drift alone (Lattorff et al 2015). suggesting that this small genomic region experienced strong selection (Lattorff et al 2015).…”

Section: Gotland Swedenmentioning

confidence: 82%

“…On two loci on chromosome 7, the reduction was greater than what could be expected from genetic drift alone (Lattorff et al 2015). suggesting that this small genomic region experienced strong selection (Lattorff et al 2015). A promising candidate gene identified in this genomic region of the honeybee that may be significant in affecting the mite's reproduction was a glucosemethanol-choline oxidoreductase (GMCOX18).…”

Section: Gotland Swedenmentioning

confidence: 99%

“…Their analysis found target regions on three chromosomes with QTL that seemed to interfere with mite reproduction (Behrens et al 2011). In a follow-up study, Lattorff et al (2015) scanned these QTL regions in samples of bees from the Gotland population before (in 2000) and after natural selection had occurred (in 2007). They found a strong overall loss of heterozygosity in these regions, suggesting that genetic drift, selection, or both had occurred in the population.…”

Section: Gotland Swedenmentioning

confidence: 99%

See 2 more Smart Citations

Natural Varroa mite-surviving Apis mellifera honeybee populations

2015

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-The Varroa destructor mite is the largest threat to apiculture worldwide and has been responsible for devastating losses of wild honeybee populations in Europe and North America. However, Varroa mite-resistant populations of A. mellifera honeybees have been reported and documented around the world with a variety of explanations for their long-term survival with uncontrolled mite infestation. This review synthesizes the work on naturally occurring survival to Varroa mites and discusses what these honeybee populations can signify for apiculture.Varroa destructor / mite resistance / host-parasite adaptations / natural selection / apiculture

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Section: Gotland Swedenmentioning

confidence: 82%

Section: Gotland Swedenmentioning

confidence: 99%

Section: Gotland Swedenmentioning

confidence: 99%

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Natural Varroa mite-surviving Apis mellifera honeybee populations

2015

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“…However, there 75 are some feral honey bee populations that have been able to rapidly acquire tolerance to Varroa, often in just a couple of years after an initial period of high mortality (Pinto et al 2004;Loper et al 2006;Villa et al 2008;Mikheyev et al 2015). Studies of genome-wide historical changes in such populations can allow us to understand the mechanisms of resistance to Varroa as well as how selection for disease resistance occurs in natural populations (Behrens 80 et al 2011;Lattorff et al 2015;Mikheyev et al 2015).…”

Section: Introduction 45mentioning

confidence: 99%

Parallel genomic evolution of parasite tolerance in wild honey bee populations

Bożek

Rangel

Arora

et al. 2018

Preprint

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Sudden biotic pressures, such as those from novel diseases and pathogens, require populations to respond rapidly or face potential extinction. How this response process takes 25 place remains poorly understood, particularly in natural environments. In this study we take advantage of unique decade-long data sets of two wild honey bee (Apis mellifera) populations in the United States to reconstruct the evolution of tolerance to a novel parasite, the ectoparasitic mite Varroa destructor. Upon the arrival of Varroa, the two geographically isolated populations simultaneously suffered massive Varroa-induced mortality, but stabilized 30 within two years. Here we sequenced and phased genomes of 465 bees sampled from both populations annually over the decade that spanned Varroa's arrival. Remarkably, we found that genetic changes were strongly correlated between the populations, suggesting parallel selective responses to Varroa parasitization. The arrival of Varroa was also correlated with an influx of genes of African origin into both populations, though surprisingly it did not substantially 35 contribute to the overall similarity of the evolutionary response between them. Genes involved in metabolic, protein processing and developmental pathways were under particularly strong selection. It is possible that interactions among highly connected gene groups in these pathways may help channelize selective responses to novel parasites, causing completely unrelated populations to exhibit parallel evolutionary trajectories when faced with the same 40 biotic pressure. Our analyses illustrate that ecologically relevant traits emerge from highly polygenic selection involving thousands of genes contributing to complex patterns of evolutionary change.

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“…Hudson et al[30,31], e.g., detected a ~50-kb selective sweep surrounding the SOD locus in Drosophila melanogaster. Using high-density QTL markers, Lattorff et al[32] detected a locus in the honeybee Apis mellifera where the allele frequency reached near fixation (allele frequency = 0.97) in a period of seven years under selection with the ectoparasitic mite Varroa destructor. Within the context of pesticide selection, only a handful of studies have identified sweeps associated with resistance and, in all cases to date, the sweeps were relatively small (< 200 kb).…”

mentioning

confidence: 99%

Selective sweeps in a nutshell; the genomic footprint of rapid insecticide resistance evolution in an insect

Calla

Demkovich

Siegel

et al. 2019

Preprint

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Relatively few genome-wide population studies of field-acquired insecticide resistance have been carried out on agricultural pests. We utilized the navel orangeworm (Amyelois transitella), the main insect pest of almond orchards in California, to study the short and long-terms effects of heavy insecticide usage in the population genomic landscape of insects. We re-sequenced the genomes of three contemporary A. transitella natural populations differing in resistance status and characterized its population genetics parameters. We detected an exceptionally large selective sweep present in all populations. This sweep has virtually no polymorphisms and extends up to 1.3 Mb (spanning 43 genes) in the resistant population. We analyzed the possible causes of this unusually strong population genetic signature, and find genes in the sweep that are associated with DDT and pyrethroid resistance. Moreover, we found that the sequence along the sweep is nearly identical in the genome assembled from a strain founded in 1966, suggesting that the underpinning for insecticide resistance may have been laid a half-century ago when the California Central Valley experienced massive use of DDT, or that DDT residues in the soil may still be at play as a selective pressure. Our findings show the effects of insecticide applications in genomes of agricultural pest. We show that insecticide application in this species has probably evolved as a stacking of selective pressures that started decades ago and which effectively reduced variation in a region that includes several genes that confer resistance to insecticides that share a mechanism of action.

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A selective sweep in a Varroa destructor resistant honeybee (Apis mellifera) population

Cited by 25 publications

References 50 publications

Natural Varroa mite-surviving Apis mellifera honeybee populations

Natural Varroa mite-surviving Apis mellifera honeybee populations

Parallel genomic evolution of parasite tolerance in wild honey bee populations

Selective sweeps in a nutshell; the genomic footprint of rapid insecticide resistance evolution in an insect

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