A Selective Simultaneous Determination of Levodopa and Serotonin Using a Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite

Babaei, Ali; Babazadeh, Mitra

doi:10.1002/elan.201000755

Cited by 51 publications

(28 citation statements)

References 67 publications

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“…4c). As seen in Table 1, compared with other electrochemical sensors for the determination of serotonin, the CNT-modified acupuncture needle obtained a low detection limit, which is comparable with that reported previously33343536373839.…”

Section: Resultssupporting

confidence: 86%

In vivo Monitoring of Serotonin by Nanomaterial Functionalized Acupuncture Needle

Tang

Ning

et al. 2016

Sci Rep

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Acupuncture treatment is amazing but controversial. Up to now, the mechanism of treating diseases by acupuncture and moxibustion is still unclear, especially the occurrence of the molecular events in local acupoints. Herein, we report an extremely stable microsensor by modifying carbon nanotube (CNT) to the tip surface of acupuncture needle and applying this CNT-modified acupuncture needle for real time monitoring of serotonin (5-HT) in vivo. To stabilize CNT modification on the needle tip surface, poly(3,4-ethylenedioxythiophene)(PEDOT) was employed as glue water to stick CNT on the needle. The detection limit of the CNT-modified needle was found to be approximately 50 nM and 78 nM in the PBS and the cell medium, respectively. In addition, the needle showed good selectivity to some inflammatory mediators and some electroactive molecules. For the first time, the CNT-modified needle could be directly probed into rat body for real time monitoring of 5-HT in vivo, showing a great potential for better understanding the mechanism of acupuncture treatment.

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Section: Resultssupporting

confidence: 86%

In vivo Monitoring of Serotonin by Nanomaterial Functionalized Acupuncture Needle

Tang

Ning

et al. 2016

Sci Rep

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“…This peak is attributed to an irreversible oxidation of the hydroxyl group present in the aromatic ring of the serotonin forming ketone species. 34 The Au/ssDNA/SWCNT surface caused a shift of 140 mV in the oxidation potential of serotonin to a less positive value when compared to the bare Au electrode (+540 mV). Additionally, the oxidation on such a catalytic surface showed a 3-fold increase in peak current compared to the unmodified one.…”

mentioning

confidence: 99%

“…Serotonin has been determined by several techniques, which integrate separation methods-such as liquid chromatography [36][37][38] and capillary electrophoresis 39 -or direct assays using potentiometry 27,29,40 and sensor-based applications. 41,42 In general, as verified in Table 1, our set up shows a LOD lower than those reported in the literature even when a preconcentration step was employed.…”

mentioning

confidence: 99%

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

et al. 2012

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This communication reports a promising platform for rapid, simple, direct, and ultrasensitive determination of serotonin. The method is related to integration of vertically aligned singlewalled carbon nanotubes (SWCNTs) in electrochemical microfluidic devices. The required microfabrication protocol is simple and fast. In addition, the nanomaterial influenced remarkably the obtained limit-of-detection (LOD) values. Our system achieved a LOD of 0.2 nmol L 21 for serotonin, to the best of our knowledge one of the lowest values reported in the literature.Glass/elastomer hybrid microfluidic platforms with integrated electrochemical detectors are powerful analytical tools. Their main advantages include: (i) low cost; (ii) chemical inertia; (iii) optical transparency; (iv) thermal, mechanical, and chemical stability; (v) automation capacity, and; (vi) easy microfabrication. In addition, they offer high values of reproducibility and sensitivity.

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“…For electrosynthesizing the MWNT-PINA com posite coating, we used a suspension containing (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) The deposition of these films on the GC electrode surface was carried out at the supersonic treatment (35 kHz). After the preparation of modified elec trodes, they were thoroughly washed with twice dis tilled water and immersed into PB.…”

Section: Electrosynthesis Of the Polymer Film And Preparation Of Compmentioning

confidence: 99%

“…Several fundamental publications in this field dealt with electrochemical determination of catecola mines, predominantly DA, with the use of electrodes modified by micro or nanoparticles of carbon and various metals or metal compounds. It was shown that in this case, the high sensitivity and selectivity of trans fer on the target components could often be achieved at the total high level of permeability [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 97%

Determination of catecolamines on electrodes modified with multiwalled carbon nanotubes

2014

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The electrochemical behavior of several biologically active catecolamines in studied on a glassy carbon electrode with the surface preliminarily modified by a composite film containing preliminarily car boxylated multi walled carbon nanotubes (MWNT). The coatings are characterized by the methods of cyclic voltammetry and scanning microscopy. It is shown that the use of hybrid composites prepared by immobiliz ing MWNT and gold nanoparticles into the film of poly(isonicotinic) acid provides the high diffusion perme ability of the surface layers and the efficiency of the electron transfer as regards catecolamines. The possibility of using these electrodes for selective determination of these substances in drugs widely used in the modern practical medicine is demonstrated.

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A Selective Simultaneous Determination of Levodopa and Serotonin Using a Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite

Cited by 51 publications

References 67 publications

In vivo Monitoring of Serotonin by Nanomaterial Functionalized Acupuncture Needle

In vivo Monitoring of Serotonin by Nanomaterial Functionalized Acupuncture Needle

Glass/PDMS hybrid microfluidic device integrating vertically aligned SWCNTs to ultrasensitive electrochemical determinations

Determination of catecolamines on electrodes modified with multiwalled carbon nanotubes

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