A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon

Fuchs, Thomas; Siegel, Jennifer J.; Burgdorf, Jeffrey; Bingman, Verner P.

doi:10.1016/j.physbeh.2005.12.003

Cited by 18 publications

(11 citation statements)

References 22 publications

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“…Efferent from these regions innervate the septal lateral, posterior hypothalamic and medial mammillary areas, the median eminence and neurohypophysis, as well as the brainstem, whereas afferent input to these regions originates from CSF-contacting cells (including 5-HT+ neurons), circumventricular organs (SFO, OVLT, area postrema), and limbic and autonomic areas of the brainstem and the prosencephalon in birds. Thus, these periventricular preoptico-hypothalamic receptors are positioned to mediate the important serotonergic functions in reproductive and chronobiologically dependent states (e.g., [99]), in sleep [100,101], in the control of thermal and fuel-related metabolism [100,102,103], and in the performance of ingestive behaviors [103,10,104,12,13], as suggested by local, ICV and systemic injection of 5-HT or drugs that interact with 5-HT 1ARs in pigeons and chickens.…”

Section: Discussionmentioning

confidence: 99%

Distribution of serotonin 5-HT 1A -binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons ( Columba livia )

Santos

Krüger

Melleu

et al. 2015

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 99%

Distribution of serotonin 5-HT 1A -binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons ( Columba livia )

Santos

Krüger

Melleu

et al. 2015

Behavioural Brain Research

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“…Alternatively, increased levels of monoamine neurotransmitters known to suppress REM sleep in mammals and birds [55] might also increase the release of hormones from the hypothalamic-pituitary-adrenal (HPA) and -thyroid (HPT) axes, resulting in activation of peripheral components of the melanocortin system [13]. Because the HPA hormone adrenocorticotropic hormone (ACTH) is the precursor that PCSK2 processes into α-MSH, ACTH released into the circulation may reach the follicle and lead to increased PCSK2 expression.…”

Section: Discussionmentioning

confidence: 99%

Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny

et al. 2013

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BackgroundIntra-specific variation in melanocyte pigmentation, common in the animal kingdom, has caught the eye of naturalists and biologists for centuries. In vertebrates, dark, eumelanin pigmentation is often genetically determined and associated with various behavioral and physiological traits, suggesting that the genes involved in melanism have far reaching pleiotropic effects. The mechanisms linking these traits remain poorly understood, and the potential involvement of developmental processes occurring in the brain early in life has not been investigated. We examined the ontogeny of rapid eye movement (REM) sleep, a state involved in brain development, in a wild population of barn owls (Tyto alba) exhibiting inter-individual variation in melanism and covarying traits. In addition to sleep, we measured melanistic feather spots and the expression of a gene in the feather follicles implicated in melanism (PCSK2).ResultsAs in mammals, REM sleep declined with age across a period of brain development in owlets. In addition, inter-individual variation in REM sleep around this developmental trajectory was predicted by variation in PCSK2 expression in the feather follicles, with individuals expressing higher levels exhibiting a more precocial pattern characterized by less REM sleep. Finally, PCSK2 expression was positively correlated with feather spotting.ConclusionsWe demonstrate that the pace of brain development, as reflected in age-related changes in REM sleep, covaries with the peripheral activation of the melanocortin system. Given its role in brain development, variation in nestling REM sleep may lead to variation in adult brain organization, and thereby contribute to the behavioral and physiological differences observed between adults expressing different degrees of melanism.

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“…5; Buzsáki, 1986, 1989; Sirota & Buzsáki, 2005; Ulanovsky & Moss, 2007). In contrast to mammals, such hippocampal sharp‐wave/ripples (SWRs) have not been reported in birds during SWS (Ookawa & Gotoh, 1965; Van Twyver & Allison, 1972; Sugihara & Gotoh, 1973; Szymczak, 1987; Fuchs et al , 2006; Martinez‐Gonzalez et al , 2008, Dos Santos et al , 2009). Instead, the avian hippocampus tends to show only slow‐waves similar to those observed in other pallial regions, albeit with a lower amplitude during SWS (Sugihara & Gotoh, 1973).…”

Section: Avian and Mammalian Sleepmentioning

confidence: 99%

Hippocampal memory consolidation during sleep: a comparison of mammals and birds

et al. 2010

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The transition from wakefulness to sleep is marked by pronounced changes in brain activity. The brain rhythms that characterize the two main types of mammalian sleep, slow-wave sleep (SWS) and rapid eye movement (REM) sleep, are thought to be involved in the functions of sleep. In particular, recent theories suggest that the synchronous slow-oscillation of neocortical neuronal membrane potentials, the defining feature of SWS, is involved in processing information acquired during wakefulness. According to the Standard Model of memory consolidation, during wakefulness the hippocampus receives input from neocortical regions involved in the initial encoding of an experience and binds this information into a coherent memory trace that is then transferred to the neocortex during SWS where it is stored and integrated within preexisting memory traces. Evidence suggests that this process selectively involves direct connections from the hippocampus to the prefrontal cortex (PFC), a multimodal, high-order association region implicated in coordinating the storage and recall of remote memories in the neocortex. The slowoscillation is thought to orchestrate the transfer of information from the hippocampus by temporally coupling hippocampal sharp-wave/ripples (SWRs) and thalamocortical spindles. SWRs are synchronous bursts of hippocampal activity, during which waking neuronal firing patterns are reactivated in the hippocampus and neocortex in a coordinated manner. Thalamocortical spindles are brief 7-14 Hz oscillations that may facilitate the encoding of information reactivated during SWRs. By temporally coupling the readout of information from the hippocampus with conditions conducive to encoding in the neocortex, the slow-oscillation is thought to mediate the transfer of information from the hippocampus to the neocortex. Although several lines of evidence are consistent with this function for mammalian SWS, it is unclear whether SWS serves a similar function in birds, the only taxonomic group other than mammals to exhibit SWS and REM sleep. Based on our review of research on avian sleep, neuroanatomy, and memory, although involved in some forms of memory consolidation, avian sleep does not appear to be involved in transferring hippocampal memories to other brain regions. Despite exhibiting the slow-oscillation, SWRs and spindles have not been found in birds. Moreover, although birds independently evolved a brain region -the caudolateral nidopallium (NCL) -involved in performing high-order cognitive functions similar to those performed by the PFC, direct connections between the NCL and hippocampus have not been found in birds, and evidence for the transfer of information from the hippocampus to the NCL or other extra-hippocampal regions is lacking. Although based on the absence of evidence for various traits, collectively, these findings suggest that unlike mammalian SWS, avian SWS may not be involved in transferring memories from the hippocampus. Furthermore, it suggests that the slow-oscillation, the defining featur...

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A selective serotonin reuptake inhibitor reduces REM sleep in the homing pigeon

Cited by 18 publications

References 22 publications

Distribution of serotonin 5-HT 1A -binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons ( Columba livia )

Distribution of serotonin 5-HT 1A -binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons ( Columba livia )

Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny

Hippocampal memory consolidation during sleep: a comparison of mammals and birds

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