A Selective Search for Biologically Active Bipartate Nucleoside Prodrugs I : Bi̇yoloji̇k Akti̇vi̇tesi̇ Olan İki̇ Kisimli Nükleosi̇t Prodrug'lari İçi̇n Seçi̇ci̇ Bi̇r Tarama I

Abstract

The primary goal of prodrug is to provide an effective and desired concentration of a parent drug at the target organ. This goal is usually achieved by improved absorption, but ideally this must occur without accompanying toxicity. For this aim, various alkyl and amino acid esters of nucleosides have been synthesized to inhibit metabolism and improve oral bioavailability. In this review, it was described important examples of prodrugs such as ddl, ara-A and AZT which are already in the market