A selective fluorescence probe for yttrium(III) based on acylhydrazone Schiff base

Zhang, Dong; Zang, Zhipeng; Zhou, Xiaoyan; Zhou, Yan; Tang, Xiaoliang; Wei, Ruiping; Liu, Weisheng

doi:10.1016/j.inoche.2009.08.007

Cited by 26 publications

(9 citation statements)

References 38 publications

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“…), which is similar to the observations reported by Liu and co-workers with yttrium and terbium complexes of acylhydrazone Schiff base. [54] These results support the deprotonation of phenolic hydrogen during complexation.…”

Section: Cation Recognition Studies Of Hlsupporting

confidence: 55%

“…Compound HL was synthesized by modification of an already reported method (Scheme 1). [53,54] A condensation reaction of 2-hydroxy-naphthaldehyde with salicyl hydrazide in methanol (1:1) provided the imine-linked receptor HL in 89.8% yield. The structures of compound HL was confirmed from its spectroscopic and analytical data (Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

“…However, this probe showed very weak fluorescence emission toward La 3+ in THF. [54] Consequently, with an aim to improve the activity of this probe for La 3+ recognition, we have synthesized fluorescent aggregates of the receptors. The fluorescent aggregates show more efficient recognition of analytes based upon AIEE.…”

Section: Konstantlanos and Co-workers Have Developed Acylhydrazonementioning

confidence: 99%

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Fluorescence modulation of naphthalene containing salicyl hydrazide‐based receptor through aggregation‐induced emission enhancement approach: Dual detection of lanthanum and cyanide ions in semi‐aqueous medium

Joshi

Ali

Rishu³

et al. 2021

Luminescence

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The sensing activity of naphthalene containing salicyl hydrazide-based fluorescence receptor has been improved through aggregation-induced enhanced emission mechanism approach in semi-aqueous medium. The receptor has been found to be selective toward La 3+ with approximately 70-fold fluorescence enhancement due to a combined effect of keto-enol tautomerism inhibition and chelation enhanced fluorescence with a detection limit of 3.91 × 10 −6 M. In addition, the receptor is also able to sense CN − with a detection limit of 3.55 × 10 −6 M via deprotonation effect, justifying its multiple analyte sensing behaviour. Hence, the current analytical methodology improves the sensing activity of the probe and also provides a greener alternative for La 3+ and CNdetection.

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Section: Cation Recognition Studies Of Hlsupporting

confidence: 55%

Section: Resultsmentioning

confidence: 99%

Section: Konstantlanos and Co-workers Have Developed Acylhydrazonementioning

confidence: 99%

See 1 more Smart Citation

Fluorescence modulation of naphthalene containing salicyl hydrazide‐based receptor through aggregation‐induced emission enhancement approach: Dual detection of lanthanum and cyanide ions in semi‐aqueous medium

Joshi

Ali

Rishu³

et al. 2021

Luminescence

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“…It has been reported that the 8-hydroxyquinoline derivative SD70 could attenuate prostate cancer cells by targeting KDM4C 11 , 12 . We acquired a series of known and/or potential KDM4 inhibitors 25 , which were synthesized and purified using an established method 26 and evaluated their activities against adriamycin-resistant cell lines HL-60/ADR and K562/ADR for the first-round screen ( Table S1 ). Next, the cytotoxicity of 9 candidates from the first-round screen was tested in adriamycin-resistant cell lines and three additional leukemia cell lines, including K562, HL-60, and THP-1 (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

KDM4 inhibitor SD49-7 attenuates leukemia stem cell via KDM4A/MDM2/p21^CIP1 axis

Li¹,

Wang²,

Gao³

et al. 2022

Theranostics

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Rationale: Traditional treatments for leukemia fail to address stem cell drug resistance characterized by epigenetic mediators such as histone lysine-specific demethylase 4 (KDM4). The KDM4 family, which acts as epigenetic regulators inducing histone demethylation during the development and progression of leukemia, lacks specific molecular inhibitors. Methods: The KDM4 inhibitor, SD49-7, was synthesized and purified based on acyl hydrazone Schiff base. The interaction between SD49-7 and KDM4s was monitored in vitro by surface plasma resonance (SPR). In vitro and in vivo biological function experiments were performed to analyze apoptosis, colony-formation, proliferation, differentiation, and cell cycle in cell sub-lines and mice. Molecular mechanisms were demonstrated by RNA-seq, ChIP-seq, RT-qPCR and Western blotting. Results: We found significantly high KDM4A expression levels in several human leukemia subtypes. The knockdown of KDM4s inhibited leukemogenesis in the MLL-AF9 leukemia mouse model but did not affect the survival of normal human hematopoietic cells. We identified SD49-7 as a selective KDM4 inhibitor that impaired the progression of leukemia stem cells (LSCs) in vitro . SD49-7 suppressed leukemia development in the mouse model and patient-derived xenograft model of leukemia. Depletion of KDM4s activated the apoptosis signaling pathway by suppressing MDM2 expression via modulating H3K9me3 levels on the MDM2 promoter region. Conclusion: Our study demonstrates a unique KDM4 inhibitor for LSCs to overcome the resistance to traditional treatment and offers KDM4 inhibition as a promising strategy for resistant leukemia therapy.

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“…Comparison with other pioneering Y 3+ and Pb 2+ probes [62][63][64][65][66][67][68][69][70][71] Trace level determination of Y 3+ and Pb 2+ using Mo(VI) complexes (M1 and M2) by uorescence method is compared with available pioneering probes and presented in Tables S1 and S2, [62][63][64][65][66][67][68][69][70][71] (ESI). † A closer look reveals that some probes may have better LOD but the method either involves uorescence Scheme 2 Plausible sensing mechanism.…”

Section: Esi) †mentioning

confidence: 99%

Mo(vi) complexes of amide–imine conjugates for tuning the selectivity of fluorescence recognition of Y(iii) vs. Pb(ii)

Chatterjee

Khanra

2022

RSC Adv.

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A selective fluorescence probe for yttrium(III) based on acylhydrazone Schiff base

Cited by 26 publications

References 38 publications

Fluorescence modulation of naphthalene containing salicyl hydrazide‐based receptor through aggregation‐induced emission enhancement approach: Dual detection of lanthanum and cyanide ions in semi‐aqueous medium

Fluorescence modulation of naphthalene containing salicyl hydrazide‐based receptor through aggregation‐induced emission enhancement approach: Dual detection of lanthanum and cyanide ions in semi‐aqueous medium

KDM4 inhibitor SD49-7 attenuates leukemia stem cell via KDM4A/MDM2/p21^CIP1 axis

Mo(vi) complexes of amide–imine conjugates for tuning the selectivity of fluorescence recognition of Y(iii) vs. Pb(ii)

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A selective fluorescence probe for yttrium(III) based on acylhydrazone Schiff base

Cited by 26 publications

References 38 publications

Fluorescence modulation of naphthalene containing salicyl hydrazide‐based receptor through aggregation‐induced emission enhancement approach: Dual detection of lanthanum and cyanide ions in semi‐aqueous medium

Fluorescence modulation of naphthalene containing salicyl hydrazide‐based receptor through aggregation‐induced emission enhancement approach: Dual detection of lanthanum and cyanide ions in semi‐aqueous medium

KDM4 inhibitor SD49-7 attenuates leukemia stem cell via KDM4A/MDM2/p21CIP1 axis

Mo(vi) complexes of amide–imine conjugates for tuning the selectivity of fluorescence recognition of Y(iii) vs. Pb(ii)

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KDM4 inhibitor SD49-7 attenuates leukemia stem cell via KDM4A/MDM2/p21^CIP1 axis