A SECOND EXAMPLE OF ANTI-Xga

Cook, I.A.; Polley, MargaretJ.; Mollison, P. L.

doi:10.1016/s0140-6736(63)91628-3

Cited by 10 publications

(4 citation statements)

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“…4 One patient received six units of antigen-positive blood with no signs of a reaction. 27 A chromium survival study on another patient showed normal survival of Xg(a+) RBCs and no posttransfusion increase in antibody strength. 28 One male Japanese patient had a slight temperature elevation and exhibited urticaria when transfused with Xg(a+) blood.…”

Section: Clinical Significancementioning

confidence: 90%

XG: the forgotten blood group system

Johnson¹

2011

Immunohematology

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The XG blood group system is best known for its contributions to the fields of genetics and chromosome mapping. This system comprises two antigens, Xg a and CD99, that are not antithetical but that demonstrate a unique phenotypic relationship. XG is located on the tip of the short arm of the X chromosome with exons 1 to 3 present in the pseudoautosomal region of the X (and Y) chromosome(s) and exons 4 to 10 located only on the X chromosome. Xg a demonstrates a clear X-linked pattern of inheritance. MIC2, the gene encoding the CD99 antigen, is found in the pseudoautosomal region of both the X and Y chromosomes. Anti-Xg a is comparatively rare, and only two examples of anti-CD99 have ever been identified. Alloanti-Xg a is considered clinically insignificant; only one example of autoanti-Xg a has been reported, but it resulted in severe hemolytic anemia. Insufficient data exist to determine the clinical significance of anti-CD99. Linkage of XG to several X-borne genes encoding inherited disorders has been demonstrated. CD99 is an adhesion molecule, and high levels are associated with some types of cancer.

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Section: Clinical Significancementioning

confidence: 90%

XG: the forgotten blood group system

Johnson¹

2011

Immunohematology

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“…One patient with anti -Xg a received six units of Xg(a + ) blood with no signs of a haemolytic reaction [38] . One patient with anti -Xg a received six units of Xg(a + ) blood with no signs of a haemolytic reaction [38] .…”

Section: X-chromosome Inactivationmentioning

confidence: 99%

Xg Blood Group System

Daniels

2013

Human Blood Groups

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“…The frequency of Xg(aÀ) in the Japanese population is 30.6% in males and 11.2% in females [3]. Most anti-Xg a producers are males who have never been transfused; thus, anti-Xg a seems to be a naturally occurring antibody that does not cause haemolytic transfusion reactions [3][4][5]. Notably, only one case of anti-Xg a was suspected of causing a transfusion reaction [4].…”

Section: Introductionmentioning

confidence: 99%

Genetic background of anti‐Xg^a producers in Japanese blood donors

et al. 2022

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Background and Objectives: The Xg blood group is composed of two antigens, Xg a (XG1) and CD99 (XG2 and MIC2). The XG and CD99 are homologous genes located on pseudoautosomal region 1 of the X and Y chromosomes. The expressions of Xg a and CD99 are co-regulated by a single nucleotide polymorphism (rs311103) in the GATA-1 binding region. Another mechanism of the Xg(aÀ) phenotype is the genomic deletion of approximately 114 kb, including the XG gene. Anti-Xg a seems to be naturally occurring by detection in males who have never been transfused. Materials and Methods:In this study, we identified 23 anti-Xg a producers among 580,115 donors (0.004%). Additional 12 anti-Xg a producers were also identified from a separate cohort.Results: All 35 anti-Xg a producers were male. Genomic DNA was obtained from 34 of 35 producers, and all 34 producers were confirmed to carry the XG-genedeficient allele (XGdel). The breakpoints of all 34 producers were identical. The XGdel was also identified in 12 non-producers of anti-Xg a among 860 donors who have no antibodies against RBCs, and the breakpoints were also identical with the anti-Xg a producers. Conclusion:Our results will serve as the basis for a more complete understanding of Xg blood group polymorphisms.

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A SECOND EXAMPLE OF ANTI-Xga

Cited by 10 publications

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XG: the forgotten blood group system

XG: the forgotten blood group system

Xg Blood Group System

Genetic background of anti‐Xg^a producers in Japanese blood donors

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A SECOND EXAMPLE OF ANTI-Xga

Cited by 10 publications

References 0 publications

XG: the forgotten blood group system

XG: the forgotten blood group system

Xg Blood Group System

Genetic background of anti‐Xga producers in Japanese blood donors

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Product

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Genetic background of anti‐Xg^a producers in Japanese blood donors