A search for susceptibility loci for anorexia nervosa: methods and sample description

Kaye, Walter H.; Lilenfeld, Lisa R.; Berrettini, Wade H.; Strober, Michael; Devlin, Bernie; Klump, Kelly L.; Goldman, David; Bulik, Cynthia M.; Halmi, Katherine A.; Fichter, Manfred M.; Kaplan, Allan S.; Woodside, D. Blake; Treasure, Janet; Plotnicov, Katherine; Pollice, Christine; Rao, R. Govinda; McConaha, Claire

doi:10.1016/s0006-3223(99)00240-1

Cited by 103 publications

(97 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, patients with AN or BN will frequently convert to the other diagnosis within their lifetime, suggesting a shared biological risk (44). Second, BN is more frequently found in relatives of patients with AN than in the general population, indicating that both disorders may share a common genetic risk (45). Individuals with no history of ED symptoms were designated as unaffected.…”

Section: Methodsmentioning

confidence: 99%

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations

Cui¹,

Moore²,

Ashimi³

et al. 2013

J. Clin. Invest.

View full text Add to dashboard Cite

Anorexia nervosa and bulimia nervosa are common and severe eating disorders (EDs) of unknown etiology. Although genetic factors have been implicated in the psychopathology of EDs, a clear biological pathway has not been delineated. DNA from two large families affected by EDs was collected, and mutations segregating with illness were identified by whole-genome sequencing following linkage mapping or by whole-exome sequencing. In the first family, analysis of twenty members across three generations identified a rare missense mutation in the estrogen-related receptor α (ESRRA) gene that segregated with illness. In the second family, analysis of eight members across four generations identified a missense mutation in the histone deacetylase 4 (HDAC4) gene that segregated with illness. ESRRA and HDAC4 were determined to interact both in vitro in HeLa cells and in vivo in mouse cortex. Transcriptional analysis revealed that HDAC4 potently represses the expression of known ESRRA-induced target genes. Biochemical analysis of candidate mutations revealed that the identified ESRRA mutation decreased its transcriptional activity, while the HDAC4 mutation increased transcriptional repression of ESRRA. Our findings suggest that mutations that result in decreased ESRRA activity increase the risk of developing EDs.

show abstract

Section: Methodsmentioning

confidence: 99%

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations

Cui¹,

Moore²,

Ashimi³

et al. 2013

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Subjects were psychiatrically evaluated using the Structured Clinical Interview (SCID) for DSM-III-R and DSM-IV and/or Schedule for Affective Disorders and Schizophrenia (SADS) inventory prior to genotyping, as part of ongoing genetic studies of these disorders 3,[29][30][31] (except the CEPH controls and exceptions noted). Healthy controls had no history of any DSM Axis I psychiatric conditions.…”

Section: Subjectsmentioning

confidence: 99%

Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype

Goldman²,

et al. 2003

View full text Add to dashboard Cite

“…5,10 Taken together, these studies suggest that perfectionism may represent an endophenotype for determining the genetic bases of eating disorders. 11 Although perfectionism has been implicated in the etiology of eating disorders, perfectionism has been reported as a specific risk factor for the development of anorexia nervosa 7 and bulimia nervosa (BN) 8 but not binge eating disorder (BED). 12 Research examining concurrent factors that discriminate among eating disorders suggests that women with AN tend to have significantly higher levels of perfectionism compared to women with BN.…”

Section: Introductionmentioning

confidence: 99%

Relationships between perfectionism and specific disordered eating behaviors

Forbush

Heatherton

Keel

2006

Intl J Eating Disorders

101

View full text Add to dashboard Cite

Objective: Perfectionism has been reported as a specific risk factor for anorexia nervosa and bulimia nervosa, but not binge eating disorder. This study examined whether these differences are due to differential associations between perfectionism and specific eating disorder behaviors.Method: Participants (N ¼ 2,482) completed the eating disorders inventory perfectionism scale and a questionnaire assessing eating disorder symptoms.Results: Perfectionism was associated with an array of disordered eating behaviors in women. However, associations were strongest for fasting and purging. Further, the association between binge eating and perfectionism was statistically mediated by fasting. In men, perfectionism was significantly associated only with fasting, and this association was greater than associations with other disordered eating behaviors. Conclusion:Results explain why previous studies have reported weak or inconsistent associations between perfectionism and binge eating and may inform etiological models of EDNOS characterized by fasting or purging. V V C 2006 by Wiley Periodicals, Inc.

show abstract

A search for susceptibility loci for anorexia nervosa: methods and sample description

Cited by 103 publications

References 54 publications

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations

Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype

Relationships between perfectionism and specific disordered eating behaviors

Contact Info

Product

Resources

About