A screening test for oral cancer using saliva samples: Proteomic analysis of biomarkers in whole saliva

Current Status of Magnetic Resonance on Saliva for Oral and Dental Health Early Diagnosis

“…For instance, oral squamous cell carcinoma (OSCC), the most common oral cavity malignancy, has been correlated with the level of expression of certain proteins that can be detected in the saliva [29,30]. Immunohistochemical staining and comparison of resected tumor tissue and non-tumor tissue of the same patient has been used as a method to further verify an increased level of proposed biomarkers in the tumor tissues [30]. Of great clinical significance, the use of liquid chromatography/mass spectroscopy for analysis of salivary metabolites presented 94.6% sensitivity and 84.4% specificity for the distinction between OSCC and the most frequent oral premalignant lesion known as leukoplakia.…”

El cáncer bucal y su relación con la proteína translocadora mitocondrial de 18kda

“…El análisis de muestras salivales es considerada una alternativa no invasiva comparada con la prueba de suero (18). El uso de la saliva como medio para el diagnóstico se basa en que la saliva lubrica toda la cavidad bucal y por lo tanto, es más probable que represente toda la superficie expuesta y las alteraciones presentes, lo cual no ocurre utilizando el examen por medio de una biopsia invasiva del tejido local, pero ésta a su vez se enfrenta a otras dificultades como la sensibilidad en relación a la contaminación por bacterias y células del sistema inmune (19).…”

Molecular biological change in oral cancer, summary of our researches

“…6). In the end, seven spots of proteins that are specifically expressed in the whole saliva of oral cancer patients before a surgery and not detected from the whole saliva after the surgery or the whole saliva of a healthy subject were selected [18][19][20].…”