A Screening Study of Thyroid Cancer and Other Thyroid Diseases among Individuals Exposed in Utero to Iodine-131 from Chernobyl Fallout

Hatch, Maureen; Brenner, Alina V.; Bogdanova, Tetiana; Derevyanko, A.; Kuptsova, Nataliya; Likhtarev, I.A.; Bouville, André; Tereshchenko, Valery P.; Kovgan, L.; Shpak, Victor; Ostroumova, Evgenia; Greenebaum, Ellen; Zablotska, Lydia B.; Ron, Elaine; Тronko, М.D.

doi:10.1210/jc.2008-2049

Cited by 69 publications

(48 citation statements)

References 24 publications

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“…In Ukraine, there are extensive risk analyses of thyroid cancer and of other thyroid diseases among individuals exposed in utero to 131 I from Chernobyl fallout [54] as well as of that of non-cancer thyroid neoplasms [55] and autoimmune thyroiditis [56]. The results of this large-scale project are expected to further refine conclusions of the earlier, concurrent and ongoing studies.…”

Section: Major Medical and Epidemiological Studies Of The Chernobyl Amentioning

confidence: 82%

The Chernobyl Accident and its Consequences

et al. 2011

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Section: Major Medical and Epidemiological Studies Of The Chernobyl Amentioning

confidence: 82%

The Chernobyl Accident and its Consequences

et al. 2011

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“…In a previous study, we investigated the radiation-related risk of thyroid diseases in a cohort of adolescents who were in utero at the time of the Chernobyl accident in Ukraine. We found a nonsignificant increase in risk for thyroid cancer, but not for other thyroid diseases, with in utero I-131 dose (EOR/Gy = 11.66; P = 0.12) (21). …”

Section: Introductionmentioning

confidence: 75%

“…Details of the study design, population and recruitment have been reported previously (21) and are described briefly here. Eligible mothers had to be pregnant at some point during the time period April 26, 1986 to June 30, 1986, had a live birth resulting from the pregnancy, and a mailing address in one of three northern oblasts (provinces) of Ukraine that were contaminated as a result of the Chernobyl accident.…”

Section: Methodsmentioning

confidence: 99%

In Utero Exposure to Iodine-131 from Chernobyl Fallout and Anthropometric Characteristics in Adolescence

et al. 2014

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Prenatal exposure to external radiation has been linked to growth retardation among atomic bomb survivors in adolescence. It is unclear from previous studies whether in utero exposure to internal radiation such as iodine-131 (I-131), which concentrates in the thyroid gland, has an effect on physical growth. We examined the associations between estimated thyroid gland dose from prenatal exposure to I-131 and self-reported height and weight in a cohort of 2,460 individuals exposed to radioactive fallout from the 1986 Chernobyl nuclear accident [mean I-131 dose = 72 (mGy)] and screened for thyroid diseases in adolescence. Using multivariable linear regression models, we estimated the mean differences in height, weight and body mass index (BMI) per unit increase in dose (100 mGy) in models adjusted for gender, age at examination, type of residence (rural/urban) and presence of thyroid disease diagnosed at screening. All of the adjustment factors as well as the trimester of exposure were evaluated as potential modifiers of the dose response. Overall, no significant dose response was found for height (P = 0.29), weight (P = 0.14) or BMI (P = 0.16). We found significant modification of the dose response for weight and BMI by presence/absence of thyroid disease (P = 0.02 and P = 0.03, respectively), but not for other factors. In individuals without thyroid disease (n = 1,856), there was a weak, significant association between I-131 thyroid dose and higher weight (210 g per 100 mGy, P = 0.02) or BMI (70 g/m2 per 100 mGy, P = 0.02) that depended on individuals (n = 52) exposed to ≥500 mGy. In individuals with thyroid disease (n = 579, 67.4% with simple diffuse goiter) no significant association with I-131 for weight (P = 0.14) or BMI (P = 0.14) was found. These results do not support the hypothesis that in utero exposure to I-131 at levels experienced by a majority of study subjects may be associated with meaningful differences in adolescent anthropometry. However, additional studies are needed to clarify whether in utero exposure to I-131 at levels > = 500 mGy may be associated with increases in weight/BMI and to evaluate the confounding or modifying role of thyroid disease, past iodine deficiency, maternal and prenatal/postnatal factors.

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“…A study of thyroid cancer among individuals exposed in utero to I 131 from Chernobyl fallout demonstrated an increased risk of thyroid carcinoma about 20 years after the accident. 7 Utiger stated that even maternal thyroid deficiency during the latter two thirds of gestation could result in mental retardation and sometimes neurologic deficits. 8 Although in utero fetal thyroid replacement therapy has been reported, termination of pregnancy was performed due to the increased risk of subsequent malignancy as well as a possible impairment of brain development, which might have already occurred during the time of presentation due to the time interval between radioactive iodine exposure and the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of fetal hypothyroidism after maternal radioactive iodine exposure during pregnancy

Başbuğ

Özgün

Murat

et al. 2010

J of Clinical Ultrasound

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A 33-year-old woman with a history of surgically treated papillary thyroid carcinoma was inadvertently given radioactive iodine when she was 16 weeks pregnant. Sonographic examination revealed fetal thyroid hypoplasia, and cordocentesis confirmed fetal hypothyroidism at 22 weeks. The pregnancy was terminated at 24 weeks. We report the first case of fetal thyroid hypoplasia diagnosed by ultrasound and cordocentesis.

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A Screening Study of Thyroid Cancer and Other Thyroid Diseases among Individuals Exposed in Utero to Iodine-131 from Chernobyl Fallout

Abstract: Our results suggest that in utero exposure to radioiodines may have increased the risk of thyroid carcinoma approximately 20 yr after the Chernobyl accident, supporting a conservative approach to medical uses of I-131 during pregnancy.

Cited by 69 publications

References 24 publications

The Chernobyl Accident and its Consequences

The Chernobyl Accident and its Consequences

In Utero Exposure to Iodine-131 from Chernobyl Fallout and Anthropometric Characteristics in Adolescence

Prenatal diagnosis of fetal hypothyroidism after maternal radioactive iodine exposure during pregnancy

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