A Screen for Genes Induced in the Suprachiasmatic Nucleus by Light

Morris, Mary E.; Viswanathan, N.; Kuhlman, Sandra J.; Davis, Fred C.; Weitz, Charles J.

doi:10.1126/science.279.5356.1544

Cited by 103 publications

(58 citation statements)

References 23 publications

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“…The Ngfi-b transcript was also reported to be strongly induced by light in the hamster SCN (Morris et al 1998), which led to the hypothesis that NGFI-B may have a role in either light entrainment or maintenance of circadian rhythmicity. However, Ngfi-b -/-mice did not exhibit any disruption of circadian locomotor behavior under constant conditions and displayed normal behavioral phase shifting in response to a variety of light stimuli (Kilduff et al 1998).…”

Section: Nrs Within the Core Clockworkmentioning

confidence: 99%

Nuclear Receptors, Metabolism, and the Circadian Clock

Yang¹,

Lamia²,

Evans³

2007

Cold Spring Harbor Symposia on Quantitative Biology

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As ligand-dependent transcription factors, the nuclear receptor superfamily governs a remarkable array of rhythmic physiologic processes such as metabolism and reproduction. To provide a "molecular blueprint" for nuclear receptor function in circadian biology, we established a diurnal expression profile of all mouse nuclear receptors in critical metabolic tissues. Our finding of broad expression and tissue-specific oscillation of nuclear receptors along with their key target genes suggests that diurnal nuclear receptor expression may contribute to established rhythms in metabolic physiology and that nuclear receptors may be involved in coupling peripheral circadian clocks to divergent metabolic outputs. Conversely, nuclear receptors may serve peripheral clock input pathways, integrating signals from the light-sensing central clock in the suprachiasmatic nucleus and other environmental cues, such as nutrients and xenobiotics. Interplay between the core circadian clock and nuclear receptors may define a large-scale signaling network that links biological timing to metabolic physiology.

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Section: Nrs Within the Core Clockworkmentioning

confidence: 99%

Nuclear Receptors, Metabolism, and the Circadian Clock

Yang¹,

Lamia²,

Evans³

2007

Cold Spring Harbor Symposia on Quantitative Biology

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“…3). The downstream signaling causes the chromatin remodeling (Crosio et al , 2000) and induces acute expression of clock genes Per1 and Per2 (Albrecht et al, 1997;Shearman et al, 1997;Shigeyoshi et al, 1997) in addition to several immediate early genes (Morris et al, 1998). It is noticeable that all of these genes are induced by light only during night.…”

Section: Resetting Of the Central Clock By Lightmentioning

confidence: 99%

Resetting Mechanism of Central and Peripheral Circadian Clocks in Mammals

2004

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“…In mammals, a pulse of light during the subjective night elicits potent induction of c-fos, fos-B, and jun-B gene expression in the suprachiasmatic nucleus (13,14). c-Fos is an oncoprotein that associates with Jun proteins to form the AP-1 (activator protein 1) complex.…”

mentioning

confidence: 99%

Common pathways in circadian and cell cycle clocks: Light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1

Hirayama

Cardone

Doi

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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The cell cycle and the circadian clock are endogenous pacemakers, which coexist in most eukaryotic cells and share a number of conceptual features. In the zebrafish, light directly regulates the timing of both clocks, although the signaling and transcriptional pathways that convey photic information to essential nuclear regulators have yet to be deciphered. We have previously established the Z3 cell line, which recapitulates the features of zebrafish circadian clock and represents an ideal system to study lightdependent signaling and gene regulation. We conducted a search for light-responsive transcription factors and found that AP-1 DNA binding is highly induced. Light induces the expression of zWee1, a cell cycle gene essential for G2͞M transition, and zCry1a, a clock gene of the feedback regulatory loop. We have found consensus AP-1 sites in the regulatory regions of both zWee1 and zCry1a genes, and we show that light inducibility of both genes is abrogated by inhibition of AP-1 function. Light also elicits chromatin remodeling by stimulating hyperacetylation at Lys-14 of histone H3 at both zWee1 and zCry1a promoters, as assessed by chromatin immunoprecipitation assays by using anti-Fos antibody. These findings provide strong evidence that circadian and cell cycle clocks share unique light-responsive pathways in zebrafish.

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A Screen for Genes Induced in the Suprachiasmatic Nucleus by Light

Cited by 103 publications

References 23 publications

Nuclear Receptors, Metabolism, and the Circadian Clock

Nuclear Receptors, Metabolism, and the Circadian Clock

Resetting Mechanism of Central and Peripheral Circadian Clocks in Mammals

Common pathways in circadian and cell cycle clocks: Light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1

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