A Scoping Review on the Effects of Carotenoids and Flavonoids on Skin Damage Due to Ultraviolet Radiation

Abstract

Skin exposure to ultraviolet (UV) rays in the sun causes premature ageing and may predispose to skin cancers. UV radiation generates excessive free radical species, resulting in oxidative stress, which is responsible for cellular and DNA damage. There is growing evidence that phytonutrients such as flavonoids and carotenoids may impede oxidative stress and prevent photodamage. We conducted a systematic review of the literature to explore the effects of certain phytonutrients in preventing skin photodamage. We searched the electronic Medline (Ovid) and Pubmed databases for relevant studies published between 2002 and 2022. The main inclusion criteria were articles written in English, and studies reporting the effects of phytonutrient-containing plants of interest on the skin or skin cells exposed to UV radiation. We focused on tea, blueberries, lemon, carrot, tomato, and grapes, which are rich in flavonoids and/or carotenoids. Out of 434 articles retrieved, 40 were identified as potentially relevant. Based on our inclusion criteria, nine articles were included in the review. The review comprises three combined in vitro and animal studies, four human studies, one in vitro research, and one mixed in vitro and human study. All the studies reported positive effects of flavonoids and carotenoid-containing plant extract on UV-induced skin damage. This evidence-based review highlights the potential use of flavonoids and carotenoids found in plants in preventing the deleterious effects of UV radiation on the skin. These compounds may have a role in clinical and aesthetic applications for the prevention and treatment of sunburn and photoaging, and may potentially be used against UV-related skin cancers.

Pulp or Peel? Comparative Analysis of the Phytochemical Content and Selected Cosmetic-Related Properties of Annona cherimola L., Diospyros kaki Thumb., Cydonia oblonga Mill. and Fortunella margarita Swingle Pulp and Peel Extracts

“…As shown in Table 6 , the highest SPF values were calculated for kumquat extracts, ranging from 6.41 ± 0.77 to 7.48 ± 0.40 for pulp and peel extracts, respectively, at the highest tested concentration (5%, v/v ). F. margarita peel and pulp extracts might be considered effective photoprotective cosmetic ingredients due to the presence of phytocompounds with known photoprotective activity—carotenoids and flavonoids [ 80 ].…”

Effect of glabridin combined with bakuchiol on UVB‐induced skin damage and its underlying mechanism: An experimental study

“…Certainly, ongoing research is dedicated to identifying compounds capable of mitigating skin photoaging, particularly emphasizing natural substances and their derivatives renowned for their antioxidant and anti‐inflammatory attributes. These include resveratrol‐enriched rice, 7 probiotics, 56 flavonoids, carotenoids, 57 ginsenoside, 58 glycyrrhizic acid, 59 and trigonalline, 60 among others.…”

The Discovery of Benzylidene‐Indenone as Selective Butyrylcholinesterase Inhibitor with Choline Acetyltransferase Gene and Neurite Promoting Abilities

“…The design of MTDLs in this study includes the indanone moiety from the well‐known AD drug, donepezil, [20] and phenolic groups. The latter were selected as many phenolics have been reported to enhance neurite outgrowth [21–23] . Moreover, extracellular Aβ aggregation is closely connected with declines in cell adhesion and neurite outgrowth [24] .…”