A scoping review of literature on clozapine from former USSR states published in Russian language

Kirilochev, Oleg; Chumakov, Egor; Kuzo, Nazar; Schoretsanitis, Georgios

doi:10.1016/j.schres.2023.09.020

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…Clozapine in the context of antipsychotic polypharmacy is very frequently prescribed for patients with schizophrenia in Russia. 67 Only animal studies of clozapine-associated myocarditis have been published in Russia, 68 but no clinical cases; thus, Russian clozapine prescribers may need to pay more attention to their clozapine titrations. It is particularly concerning that the international organization pharmacovigilance database has never received any report on clozapine ADRs from Russia.…”

Section: Clozapine-associated Myocarditis In Russia and Eastern Europementioning

confidence: 99%

Can Slow Personalized Titration Using C-Reactive Protein Monitoring Decrease the High Rates and Mortality of Clozapine-Associated Myocarditis Seen in Some Countries? A Call for Research

de Leon

2024

J Clin Psychopharmacol

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Purpose/Background The hypothesis that slower personalized titration may prevent clozapine-associated myocarditis and decrease the disproportion incidence of 3% found in Australia was not described in a recent Australian article in this journal. Methods Six countries in addition to Australia have published information suggesting a similar incidence of clozapine-associated myocarditis. On September 19, 2023, PubMed searches were updated for articles from the United States, Korea, Japan, Canada, New Zealand, and Turkey. Findings/Results An incidence of 3.5% (4/76) was found in a US hospital, but US experts were the first to propose that clozapine-associated myocarditis may be a hypersensitivity reaction associated with rapid titration and possibly preventable. Koreans and Japanese are of Asian ancestry and need lower minimum therapeutic doses for clozapine than patients of European ancestry. A 0.1% (2/1408) incidence of myocarditis during clozapine titration was found in a Korean hospital, but pneumonia incidence was 3.7% (52/1408). In 7 Japanese hospitals, 34% (37/110) of cases of clozapine-associated inflammation were found during faster titrations (based on the official Japanese titration) versus 13% (17/131) during slower titrations (based on the international titration guideline for average Asian patients). Recent limited studies from Canada, New Zealand, and Turkey suggest that slower personalized titration considering ancestry may help prevent clozapine-associated myocarditis. Implications/Conclusions Other countries have very limited published data on clozapine-associated myocarditis. Based on a recent Australian case series and these non-Australian studies, the author proposes that Australia (and other countries) should use slow personalized titration for clozapine based on ancestry and c-reactive protein monitoring.

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Section: Clozapine-associated Myocarditis In Russia and Eastern Europementioning

confidence: 99%

Can Slow Personalized Titration Using C-Reactive Protein Monitoring Decrease the High Rates and Mortality of Clozapine-Associated Myocarditis Seen in Some Countries? A Call for Research

de Leon

2024

J Clin Psychopharmacol

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Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK

De las Cuevas,

Sanz,

Gross

et al. 2024

Schizophrenia Research

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Promoting safer and wider worldwide use of clozapine

de Leon

2024

Schizophrenia Research

View full text Add to dashboard Cite

A scoping review of literature on clozapine from former USSR states published in Russian language

Cited by 3 publications

References 32 publications

Can Slow Personalized Titration Using C-Reactive Protein Monitoring Decrease the High Rates and Mortality of Clozapine-Associated Myocarditis Seen in Some Countries? A Call for Research

Can Slow Personalized Titration Using C-Reactive Protein Monitoring Decrease the High Rates and Mortality of Clozapine-Associated Myocarditis Seen in Some Countries? A Call for Research

Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK

Promoting safer and wider worldwide use of clozapine

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