A Scoping Literature Review of the Relation between Nutrition and ASD Symptoms in Children

Wurff, I.S.M. van der; Oenema, Anke; Ruijter, Dennis de; Vingerhoets, Claudia; Amelsvoort, Thérèse van; Rutten, Bart P. F.; Mulkens, Sandra; Köhler, Sebastian; Schols, A.M.W.J.; Groot, Renate De

doi:10.3390/nu14071389

Cited by 9 publications

(4 citation statements)

References 92 publications

(200 reference statements)

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“…Due to the widespread nutritional deficiency and metabolic imbalance in ASD, some researchers focused on the supplements of nutrition or change of diet in the treatment of ASD, which includes vitamin D, omega-3 fatty acid, folinic acid, probiotics, coenzyme Q10, gluten free diet, etc. However, the evidence for the relation between supplements nutrition or change of diet and ASD symptoms in childhood is generally insufficient ( 78 ). Other promising treatments include fecal microbiota transplantation, hyperbaric oxygen, Tomatis sound, etc.…”

Section: Discussionmentioning

confidence: 99%

A bibliometrics analysis and visualization of autism spectrum disorder

Rong

Zhang

et al. 2022

Front. Psychiatry

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BackgroundThe prevalence of autism spectrum disorder (ASD) increased rapidly in the last 20 years. Although related research has developed rapidly, little is known about its etiology, diagnostic marker, or drug treatment, which forces researchers to review and summarize its development process and look for the future development direction.MethodsWe used bibliometrics to analyze papers of ASD in the Web of Science from 1998 to 2021, to draw the network of authors, institutions, countries, and keywords in the ASD field, and visualize the results.ResultsA total of 40,597 papers were included with a continually increasing trend. It turns out that the research on ASD is mainly concentrated in universities. The United States has the largest number of ASD studies, followed by England and Canada. The quality of papers related to ASD is generally high, which shows that ASD research has become a hot spot of scientific research. The keywords of ASD etiology and diagnostic markers can be classified into at least 7 aspects. The detection of keywords shows that ASD research is mostly based on its subtypes, takes children as the study population, focuses on neurodevelopmental imaging or genetics, and pays attention to individual differences. And ASD research has changed greatly under the impact of Corona Virus Disease 2019 in the past 2 years.ConclusionWe consider the future development direction should be based on the improvement of case identification, accurate clinical phenotype, large-scale cohort study, the discovery of ASD etiology and diagnostic markers, drug randomized controlled trials, and telehealth.

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Section: Discussionmentioning

confidence: 99%

A bibliometrics analysis and visualization of autism spectrum disorder

Rong

Zhang

et al. 2022

Front. Psychiatry

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“…Further, consumption of foods with gluten and casein results in a pronounced presentation of ASD in young children. Modifying nutrient intake to gluten-free and casein-free (GFCF) has been proven effective in controlling the condition and suppressing its manifestation [12]. Hence, a particular nutrition plan is suggested for children with ASD (see Fig 3).…”

Section: Offspring Genetic and Nutritionmentioning

confidence: 99%

The Relationship Between Dietary Patterns and ASD

Li¹

2022

HSET

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The dietary intake pattern of the mother when preparing for pregnancy, during pregnancy, and the nutritional exposure of the infant after birth have a bearing on the likelihood of the infant developing autism spectrum disorder (ASD). Many types of research have revealed a relationship between diet and the onset of ASD. However, it has not been established whether diet can be used to control the manifestation of ASD or in the prevention of ASD in unborn children. Therefore, there is an interest in ascertaining the main reasons for the relationship between dietary patterns and ASD. This paper analyzes studies about nutrition and its influence on ASD. In addition, the research explores the whole spectrum of environmental factors, namely external and internal ones, and their potential impact on an infant. Furthermore, the paper discusses the nutrition of the offspring and an approach to preventing the risk of ASD. The combination of different factors such as the mother's nutrition at various stages, the nutrition available to the infant, and the environment have been indicated in the results of the analysis to determine the level of risk for ASD in children. In this regard, further investigation of ASD prevention among infants is highly important and should be encouraged.

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“…It has become evident that nutrition affects early brain development and contributes to later mental health in youth with ASD. Indeed, many dietary agents are important for both the structural integrity of the brain and functional processes such as synaptogenesis and neurotransmitter synthesis [17]. Despite the lack of robust evidence to provide practical nutrition guidelines, several articles have suggested that specific dietary interventions may play a role in the management of some symptoms, functions, and clinical domains in patients with ASD [18,19].…”

Section: Introductionmentioning

confidence: 99%

The Emerging Role of Flavonoids in Autism Spectrum Disorder: A Systematic Review

Savino

Medoro

Alì

et al. 2023

JCM

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Although autism spectrum disorder (ASD) is a multifaceted neurodevelopmental syndrome, accumulating evidence indicates that oxidative stress and inflammation are common features of ASD. Flavonoids, one of the largest and best-investigated classes of plant-derived compounds, are known to exert antioxidant, anti-inflammatory, and neuroprotective effects. This review used a systematic search process to assess the available evidence on the effect of flavonoids on ASD. A comprehensive literature search was carried out in PubMed, Scopus, and Web of Science databases following the PRISMA guidelines. A total of 17 preclinical studies and 4 clinical investigations met our inclusion criteria and were included in the final review. Most findings from animal studies suggest that treatment with flavonoids improves oxidative stress parameters, reduces inflammatory mediators, and promotes pro-neurogenic effects. These studies also showed that flavonoids ameliorate the core symptoms of ASD, such as social deficits, repetitive behavior, learning and memory impairments, and motor coordination. However, there are no randomized placebo-controlled trials that support the clinical efficacy of flavonoids in ASD. We only found open-label studies and case reports/series, using only two flavonoids such as luteolin and quercetin. These preliminary clinical studies indicate that flavonoid administration may improve specific behavioral symptoms of ASD. Overall, this review is the first one to systematically report evidence for the putative beneficial effects of flavonoids on features of ASD. These promising preliminary results may provide the rationale for future randomized controlled trials aimed at confirming these outcomes.

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A Scoping Literature Review of the Relation between Nutrition and ASD Symptoms in Children

Cited by 9 publications

References 92 publications

A bibliometrics analysis and visualization of autism spectrum disorder

A bibliometrics analysis and visualization of autism spectrum disorder

The Relationship Between Dietary Patterns and ASD

The Emerging Role of Flavonoids in Autism Spectrum Disorder: A Systematic Review

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