A scintillating nanoplatform with upconversion function for the synergy of radiation and photodynamic therapies for deep tumors

Feng, Yansong; Liu, Xiaomeng; Li, Qiqing; Mei, Shilin; Wu, Kefan; Yuan, Jun; Tu, Langping; Que, Ive; Tamburini, Filippo; Baldazzi, Fabio; Chan, Alan; Cruz, Luis J.; Zuo, Jing; Yao, Chang‐Jiang; Zhang, Hong

doi:10.1039/d1tc04930e

Cited by 13 publications

(6 citation statements)

References 51 publications

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“…859,860 Phototherapy as an emerging method, holds the advantage of noninvasiveness, while it is limited by penetration. [861][862][863] During these decades, researchers have exploited various sorts of ingenious combinations to bring their superiority into full play and overcome their deficiency. The combinations are mainly divided into the below three aspects.…”

Section: Nps For Radiophototherapymentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.

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Section: Nps For Radiophototherapymentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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“…Poly(ethylene) glycol (PEG) is a general nanoparticle surface modification for extending circulation times of nanoparticles in vivo by reducing protein adsorption and lowering interactions of PEGylated nanomaterials with organs and cells of the mononuclear phagocyte system. [80,84,92] However, recent studies have shown the potential for PEG coatings to cause unwanted immune side effects. As the details of PEG-mediated toxicity are outside the scope of this article, the authors recommend a review that was recently published by our research group covering PEG-mediated nanoparticle toxicity and other potential toxic effects of nanoparticles in animals and humans.…”

Section: Biocompatibility and Biodistributionmentioning

confidence: 99%

Bioimaging with Upconversion Nanoparticles

Mettenbrink

Yang

Wilhelm

2022

Advanced Photonics Research

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Bioimaging enables the spatiotemporal visualization of biological processes at various scales empowered by a range of different imaging modalities and contrast agents. Upconversion nanoparticles (UCNPs) represent a distinct type of such contrast agents with the potential to transform bioimaging due to their unique optical properties and functional design flexibilities. This review explores and discusses the opportunities, challenges, and limitations that UCNPs exhibit as bioimaging probes and highlights applications with spatial dimensions ranging from the single nanoparticle level to cellular, tissue, and whole animal imaging. Recent advancements in bioimaging applications enabled by UCNPs, including super‐resolution techniques and multimodal imaging methods are summarized, and a perspective on the future potential of UCNP‐based technologies in bioimaging research and clinical translation is provided. This review may provide a valuable resource for researchers interested in exploring and applying UCNP‐based bioimaging technologies.

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“…From this perspective, X-PDT can also be considered a radiation-resistant radiosensitization method. 57–61…”

Section: Introductionmentioning

confidence: 99%

“…From this perspective, X-PDT can also be considered a radiation-resistant radiosensitization method. [57][58][59][60][61] The idea of combining the deep penetration of X-rays and the specific targeting of phototherapy was first proposed by Chen et al in 2006, and since then, the field has grown exponentially. [62][63][64][65][66] However, X-rays cannot directly excite PSs to produce ROS due to the mismatch between the energy gap of most PSs and X-rays.…”

Section: Introductionmentioning

confidence: 99%