A Scintigraphic Study of Oral, Pharyngeal, and Esophageal Transit in Patients with Stroke

Silva, Ana Cristina Viana; Fábio, Soraia Ramos Cabette; Dantas, Roberto Oliveira

doi:10.1007/s00455-007-9117-0

Cited by 29 publications

(26 citation statements)

References 21 publications

(28 reference statements)

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“…Clearance was the total exposure of an ROI to the bolus, which represents the interval between the arrival of the bolus head in the ROI and the departure of the bolus tail from the ROI. The definitions of these ROIs and of the measurements performed have been described and depicted previously [9][10][11][12].…”

Section: Methodsmentioning

confidence: 99%

Oral, pharyngeal, and esophageal transit of an acidic bolus in healthy subjects

2013

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Background The swallowing function is influenced by chemical and sensory stimuli. The aim of this investigation was to evaluate the effect of an acidic sour bolus on its oral, pharyngeal, and esophageal transit in healthy volunteers. Method Scintigraphic evaluation of the transit was performed in 43 healthy subjects aged 23-71 years. Each subject swallowed, in a random sequence, 5 mL of two liquid boluses: acidic (50 mL of water with 3 g of concentrated lemon juice, pH 3.0) and neutral (water, pH 6.8), both labeled with 37 MBq of technetium-99m phytate. A series of images of each swallow were acquired at 20 frames/s for 20 s with the subjects sitting in front of the collimator of the gamma camera. Results There was no difference between neutral and acidic boluses in terms of their transit and clearance durations and in the amount of residues when passing through the mouth and pharynx. In the proximal esophagus, the transit and clearance were longer with the neutral bolus (clearance 1.40 ± 0.11 s) than with the acidic bolus (1.17 ± 0.07 s, p = 0.04). In the distal esophagus, the transit and clearance were longer with the acidic bolus (clearance 10.66 ± 0.87 s) than with the neutral bolus (6.60 ± 0.58 s, p = 0.01). The amount of residues in the middle and distal esophagus was greater with the acidic bolus. There was no correlation between distal esophageal clearance duration and the amount of residues with the neutral bolus, but there was a positive correlation with the acidic bolus. Conclusion An acidic bolus causes slower bolus transit in the distal esophageal body as compared to a neutral bolus.

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Section: Methodsmentioning

confidence: 99%

Oral, pharyngeal, and esophageal transit of an acidic bolus in healthy subjects

2013

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“…Clearance was the total exposure to the bolus in a ROI, which represents the interval between the arrival of the bolus head into the ROI and the departure of the bolus tail from the ROI. The definition of these ROIs and of the measurements performed were previously described and shown (1,6,7,16) . The statistical analysis of transit and clearance times and the amount of residues was made using a linear model with mixed effects (14) .…”

Section: Methodsmentioning

confidence: 99%

Effect of a Bitter Bolus on Oral, Pharyngeal and Esophageal Transit of Healthy Subjects

Alves

Secaf

Dantas

2013

Arq. Gastroenterol.

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-Context -During swallowing, boluses stimulate sensory receptors of the oral, pharyngeal, laryngeal, and esophageal regions. Sweet and tasteless foods are more acceptable for swallowing than bitter foods. A bitter bolus is unpleasant for most subjects. Our hypothesis was that the ingestion of a bitter bolus might alter the oral behavior, pharyngeal and esophageal transit when compared to a sweet bolus. Objective -To evaluate whether the bitter taste of a liquid bolus causes alteration on oral, pharyngeal and/or esophageal transit in normal subjects in comparison with sweet bolus. Method -Scintigraphic evaluation of oral, pharyngeal and esophageal transit was performed in 43 asymptomatic subjects, 22 women and 21 men, ages 23-71 years, without problems with the ingestion of liquid and solid foods, and without digestive, cardiac or neurologic diseases. Each subject swallowed in random sequence and at room temperature 5 mL of a liquid bolus with bitter taste, prepared with 50 mL of water with 2 g of leaves of Peumus boldus, heated until boiling (boldus tea), and 5 mL of a liquid bolus with sweet taste, prepared with 50 mL of water with 3 g of sucrose, both labeled with 37 MBq of technetium phytate (Tc 99m ). Results -There was no difference between the bitter bolus and the sweet bolus in mouth, pharynx and esophageal transit and clearance duration and in the amount of residues. Conclusion -A bitter bolus, considered an unpleasant bolus, does not alter the duration of oral, pharyngeal and esophageal phases of swallowing, when compared with a sweet bolus, considered a pleasant bolus.

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“…This value does not significantly change after the intake of an acidic liquid bolus [35]; while after the 161 ingestion of a paste bolus, only the residues in the oesophagus significantly increases up to 50% [34]. Thus, 162 the swallowing process leads to a complete removal of the disintegrated and/or dissolved ODx within 5 to 163 10 min [2].…”

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confidence: 96%

“…The restricted space of the oral cavity limits the size of the dosage form: ODF with a size of 2×2cm 2 [34]. This value does not significantly change after the intake of an acidic liquid bolus [35]; while after the 161 ingestion of a paste bolus, only the residues in the oesophagus significantly increases up to 50% [34].…”

mentioning

confidence: 99%